Clinical Value of Ultrasonography and Serum Markers in Preoperative N Staging of Thyroid Cancer
文献类型：期刊论文
| 作者 | Wang, Hui2; Zhao, Shanshan3; Xu, Chunyang1; Yao, Jincao4; Yu, Xiuhua2; Xu, Dong4 |
| 刊名 | CELLS
 |
| 出版日期 | 2022-11-01 |
| 卷号 | 11 |
| 关键词 | lymph node metastasis neoplasm staging thyroglobulin thyroid cancer ultrasonography |
| DOI | 10.3390/cells11223621 |
| 通讯作者 | Yu, Xiuhua(yuxiuhuaxin@126.com) ; Xu, Dong(xudong@zjcc.org.cn) |
| 英文摘要 | We aimed to determine factors influencing lymph node metastasis (LNM) and develop a more effective method to assess preoperative N staging. Overall, data of 2130 patients who underwent thyroidectomy for thyroid cancer between 2018 and 2021 were retrospectively analysed. Patients were divided into groups according to pN0, pN1a, and pN1b stages. Pathology was used to analyse the correlation between preoperative serum marker indicators and LNM. Receiver operating characteristic curves were used to compare the diagnostic value of ultrasound (US) examination alone, serum thyroglobulin, age, and combined method for LNM. A significant moderate agreement was observed between preoperative US and postoperative pathology for N staging. Between the pN0 and pN1 (pN1a + pN1b) groups, the differences in free triiodothyronine, anti-thyroid peroxidase antibody, and serum thyroglobulin levels were statistically significant. Among the indicators, serum thyroglobulin was an independent predictor of LNM. The area under the receiver operating characteristic curve was 0.610 for serum thyroglobulin level for predicting LNM, 0.689 for US alone, and 0.742 for the combined method. Both preoperative US and serum thyroglobulin level provide a specific value when evaluating the N staging of thyroid cancer, and the combined method is more valuable in the diagnosis of LNM than US alone. |
| WOS关键词 | CENTRAL NECK DISSECTION ; LYMPH-NODE METASTASES ; THYROGLOBULIN ; CARCINOMA ; ULTRASOUND ; NODULES ; MALIGNANCY ; PREDICT ; DIAGNOSIS ; METAANALYSIS |
| 资助项目 | National Natural Science Foundation of China[82071946] ; Zhejiang Provincial Natural Science Foundation of China[LSD19H180001] ; Zhejiang Provincial Natural Science Foundation of China[LZY21F030001] ; Project of Zhejiang Medical and Health Science and Technology Plan[2021KY099] |
| WOS研究方向 | Cell Biology |
| 语种 | 英语 |
| 出版者 | MDPI |
| WOS记录号 | WOS:000887074500001 |
| 资助机构 | National Natural Science Foundation of China ; Zhejiang Provincial Natural Science Foundation of China ; Project of Zhejiang Medical and Health Science and Technology Plan |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/131658]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Yu, Xiuhua; Xu, Dong |
| 作者单位 | 1.Joint Serv Support Force 903 Hosp, Dept Gen Surg, Hangzhou 310013, Peoples R China 2.Joint Serv Support Force 903 Hosp, Dept Ultrasound, Hangzhou 310013, Peoples R China 3.Shaoxing Peoples Hosp, Dept Ultrasound, Shaoxing 312000, Peoples R China 4.Chinese Acad Sci, Univ Chinese Acad Sci, Canc Hosp,Key Lab Head & Neck Canc Translat Res Z, Dept Ultrasound,Zhejiang Canc Hosp,Inst Basic Med, Hangzhou 310022, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Hui,Zhao, Shanshan,Xu, Chunyang,et al. Clinical Value of Ultrasonography and Serum Markers in Preoperative N Staging of Thyroid Cancer[J]. CELLS,2022,11. |
| APA | Wang, Hui,Zhao, Shanshan,Xu, Chunyang,Yao, Jincao,Yu, Xiuhua,&Xu, Dong.(2022).Clinical Value of Ultrasonography and Serum Markers in Preoperative N Staging of Thyroid Cancer.CELLS,11. |
| MLA | Wang, Hui,et al."Clinical Value of Ultrasonography and Serum Markers in Preoperative N Staging of Thyroid Cancer".CELLS 11(2022). |
入库方式： OAI收割
来源：合肥物质科学研究院
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