Development and validation of an autophagy-related long non-coding RNA prognostic signature for cervical squamous cell carcinoma and endocervical adenocarcinoma
文献类型：期刊论文
| 作者 | Zhou, Shuguang2,3; Zhang, Weiyu2,3; Cao, Wujun4; Jin, Qinqin2,3; Jiang, Xiya2,3; Jiang, Xiaomin2,3; Yang, Yinting2,3; Yao, Hui2,3; Chen, Guo2,3; Gao, Wei2,3 |
| 刊名 | FRONTIERS IN ONCOLOGY
 |
| 出版日期 | 2022-11-03 |
| 卷号 | 12 |
| ISSN号 | 2234-943X |
| 关键词 | cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) long noncoding RNA (lncRNA) autophagy-related genes (ARGs) autophagy-related lncRNAs (ARLs) prognostic signature immune infiltration |
| DOI | 10.3389/fonc.2022.1049773 |
| 通讯作者 | Zhou, Shuguang(zhoushuguang@ahmu.edu.cn) ; Tong, Zhuting(zhuting_tong@ahmu.edu.cn) |
| 英文摘要 | BackgroundIn this study, we aimed to investigate the signature of the autophagy-related lncRNAs (ARLs) and perform integrated analysis with immune infiltration in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC). Methods and resultsThe UCSC Xena and HADb databases provided the corresponding data. The ARLs were selected via constructing a co-expression network of autophagy-related genes (ARGs) and lncRNAs. Univariate Cox regression analysis combined with LASSO regression and multivariate Cox regression analysis were utilized to screen lncRNAs. The ARL risk signature was established by Cox regression and tested if it was an independent element bound up with patient prognosis. We used the xCell algorithm and ssGSEA to clarify the pertinence between immune infiltration and the expression of ARLs. Finally, we predicted the sensitivity of drug treatment as well as the immune response. Results indicated that the three prognostic ARLs (SMURF2P1, MIR9-3HG, and AC005332.4) possessed significant diversity and constituted the ARL signature. Risk score was an individual element (HR = 2.82, 95% CI = 1.87-4.30; p < 0.001). Immune infiltration analysis revealed significant increases in central memory CD8(+) T cells, endothelial cells, CD8(+) naive T cells, and preadipocytes in the high-risk group (p < 0.05). There were 10 therapeutic agents that varied significantly in their estimated half-maximal inhibitory concentrations in the two groups. According to the experimental validation, we found that SMURF2P1 belongs to the co-stimulatory genes and might assume greater importance in the development of cervical adenocarcinoma. MIR9-3HG and AC005332.4 belonged to the tumor-suppressor genes and they may play a more positive role in cervical squamous cell carcinoma. ConclusionsThis research explored and validated a novel signature of the ARLs, which can be applied to forecast the prognosis of patients with CESC and is closely associated with immune infiltration. |
| WOS关键词 | CANCER ; LNCRNA |
| 资助项目 | Applied Medicine Research Project of Hefei Health Commission ; Research Fund Project of Anhui Medical University ; Natural Science Foundation of Higher Education Institutions of Anhui Province ; [HWKJ2019-172-14] ; [2020xkj236] ; [KJ2021A0352] |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| 出版者 | FRONTIERS MEDIA SA |
| WOS记录号 | WOS:000888291700001 |
| 资助机构 | Applied Medicine Research Project of Hefei Health Commission ; Research Fund Project of Anhui Medical University ; Natural Science Foundation of Higher Education Institutions of Anhui Province |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/131679]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Zhou, Shuguang; Tong, Zhuting |
| 作者单位 | 1.Chinese Acad Sci, Inst Hlth & Med Technol, Hefei Inst Phys Sci, Anhui Prov Key Lab Med Phys & Technol, Hefei, Peoples R China 2.Anhui Med Univ, Affiliated Matern & Child Healthcare Hosp, Dept Gynecol, Hefei, Peoples R China 3.Anhui Prov Matern & Child Healthcare Hosp, Dept Gynecol, Hefei, Peoples R China 4.Anhui Prov Matern & Child Healthcare Hosp, Dept Clin Lab, Hefei, Peoples R China 5.Anhui Med Univ, Affiliated Hosp 1, Dept Radiat Oncol, Hefei, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Shuguang,Zhang, Weiyu,Cao, Wujun,et al. Development and validation of an autophagy-related long non-coding RNA prognostic signature for cervical squamous cell carcinoma and endocervical adenocarcinoma[J]. FRONTIERS IN ONCOLOGY,2022,12. |
| APA | Zhou, Shuguang.,Zhang, Weiyu.,Cao, Wujun.,Jin, Qinqin.,Jiang, Xiya.,...&Tong, Zhuting.(2022).Development and validation of an autophagy-related long non-coding RNA prognostic signature for cervical squamous cell carcinoma and endocervical adenocarcinoma.FRONTIERS IN ONCOLOGY,12. |
| MLA | Zhou, Shuguang,et al."Development and validation of an autophagy-related long non-coding RNA prognostic signature for cervical squamous cell carcinoma and endocervical adenocarcinoma".FRONTIERS IN ONCOLOGY 12(2022). |
入库方式： OAI收割
来源：合肥物质科学研究院
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。