Ambient PM2.5 exposure causes cellular senescence via DNA damage, micronuclei formation, and cGAS activation
文献类型：期刊论文
| 作者 | Wu, Tao2,3; Xu, Shengmin1; Chen, Biao2; Bao, Lingzhi5; Ma, Jie5; Han, Wei2 ; Xu, An2; Yu, Kwan Ngok4,6; Wu, Lijun1,2; Chen, Shaopeng2,5
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| 刊名 | NANOTOXICOLOGY
 |
| 出版日期 | 2022-11-17 |
| ISSN号 | 1743-5390 |
| 关键词 | PM2 5 senescence cGAS micronuclei DNA damage |
| DOI | 10.1080/17435390.2022.2147460 |
| 通讯作者 | Chen, Shaopeng(20200080@wnmc.edu.cn) |
| 英文摘要 | Ambient PM2.5 is one of the environmental risk factors and was correlated with senescence-related diseases based on the epidemiologic investigation. However, little is known about senescence induced by PM2.5 as well as the underlying mechanisms. In this study, we demonstrated that PM2.5 exposure aggravated cellular senescence in vivo and in vitro, and disrupted micronuclei (MN) played a vital role in this process. Our results suggested that the nuclear envelope (NE) of PM2.5-induced MN was ruptured. Subsequently, cGAS was found to localize to approximately 80% of the disrupted MN but few for intact MN. Upon examination of cGAMP and SA-beta-Gal, the cGAS-STING pathway was found activated and related to cellular senescence induced by PM2.5. Taken together, we reported a novel finding that PM2.5 exposure causes cellular senescence via DNA damage, MN formation, and cGAS activation. These results revealed the potential toxicity of PM2.5 and its related mechanisms in cellular senescence. |
| WOS关键词 | CELLS ; INJURY ; TUMOR |
| 资助项目 | NSFC ; Key Program of 13th five-year plan, CASHIPS[U22A20406] ; Anhui Provincial Natural Science Foundation[KP-2017-05] ; [2108085MB41] ; [2008085MC66] |
| WOS研究方向 | Science & Technology - Other Topics ; Toxicology |
| 语种 | 英语 |
| 出版者 | TAYLOR & FRANCIS LTD |
| WOS记录号 | WOS:000889367200001 |
| 资助机构 | NSFC ; Key Program of 13th five-year plan, CASHIPS ; Anhui Provincial Natural Science Foundation |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/131721]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Chen, Shaopeng |
| 作者单位 | 1.Anhui Univ, Inst Phys Sci & Informat Technol, Informat Mat & Intelligent Sensing Lab Anhui Prov, Hefei, Peoples R China 2.Chinese Acad Sci, Hefei Inst Phys Sci, High Magnet Field Lab, Key Lab High Magnet Field & Ion Beam Phys Biol, Hefei, Peoples R China 3.Univ Sci & Technol China, Hefei, Peoples R China 4.City Univ Hong Kong, State Key Lab Marine Pollut, Hong Kong, Peoples R China 5.Wannan Med Coll, Sch Publ Hlth, Wuhu, Peoples R China 6.City Univ Hong Kong, Dept Phys, Hong Kong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Tao,Xu, Shengmin,Chen, Biao,et al. Ambient PM2.5 exposure causes cellular senescence via DNA damage, micronuclei formation, and cGAS activation[J]. NANOTOXICOLOGY,2022. |
| APA | Wu, Tao.,Xu, Shengmin.,Chen, Biao.,Bao, Lingzhi.,Ma, Jie.,...&Chen, Shaopeng.(2022).Ambient PM2.5 exposure causes cellular senescence via DNA damage, micronuclei formation, and cGAS activation.NANOTOXICOLOGY. |
| MLA | Wu, Tao,et al."Ambient PM2.5 exposure causes cellular senescence via DNA damage, micronuclei formation, and cGAS activation".NANOTOXICOLOGY (2022). |
入库方式： OAI收割
来源：合肥物质科学研究院
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