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Vanguard is a Glucose Deprivation-Responsive Long Non-Coding RNA Essential for Chromatin Remodeling-Reliant DNA Repair

文献类型：期刊论文

作者Zhang, Ben2; Thorne, Rick Francis3; Zhang, Pengfei2,4; Wu, Mian2,3; Liu, Lianxin1,2,5
刊名ADVANCED SCIENCE
出版日期2022-09-01
关键词genomic stability HMGB1 long non-coding RNAs PARP inhibitors Vanguard
DOI10.1002/advs.202201210
通讯作者Zhang, Pengfei(zpf1990@ustc.edu.cn) ; Wu, Mian(wumian@ustc.edu.cn) ; Liu, Lianxin(liulx@ustc.edu.cn)
英文摘要Glucose metabolism contributes to DNA damage response pathways by regulating chromatin remodeling, double-strand break (DSB) repair, and redox homeostasis, although the underlying mechanisms are not fully established. Here, a previously uncharacterized long non-coding RNA is revealed that is call Vanguard which acts to promote HMGB1-dependent DNA repair in association with changes in global chromatin accessibility. Vanguard expression is maintained in cancer cells by SP1-dependent transcription according to glucose availability and cellular adenosine triphosphate (ATP) levels. Vanguard promotes complex formation between HMGB1 and HDAC1, with the resulting deacetylation of HMGB1 serving to maintain its nuclear localization and DSB repair function. However, Vanguard downregulation under glucose limiting conditions promotes HMGB1 translocation from the nucleus, increasing DNA damage, and compromising cancer cell growth and viability. Moreover, Vanguard silencing increases the effectiveness of poly (ADP-ribose) polymerase inhibitors against breast cancer cells with wild-type breast cancer gene-1 status, suggesting Vanguard as a potential therapeutic target.
WOS关键词STRAND BREAK REPAIR ; UP-REGULATION ; CANCER ; HISTONE ; HMGB1 ; EXPRESSION ; METABOLISM ; DYNAMICS ; PROTEIN ; DAMAGE
资助项目National Natural Science Foundation of China[81820108021] ; National Natural Science Foundation of China[U19A2008] ; National Natural Science Foundation of China[81972307] ; National Natural Science Foundation of China[31871437] ; National Natural Science Foundation of China[32000526] ; National Key R&D Program of China[2019YFA0709300] ; China Postdoctoral Science Foundation[2021T140646]
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science
语种英语
WOS记录号WOS:000848253500001
出版者WILEY
资助机构National Natural Science Foundation of China ; National Key R&D Program of China ; China Postdoctoral Science Foundation
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/131824]  
专题中国科学院合肥物质科学研究院
通讯作者Zhang, Pengfei; Wu, Mian; Liu, Lianxin
作者单位1.First Affiliated Hosp USTC, Anhui Prov Key Lab Hepatopancreatobiliary Surg, Hefei 230001, Anhui, Peoples R China
2.Univ Sci & Technol China, Affiliated Hosp USTC 1, Dept Hepatobiliary Surg, Div Life Sci & Med, Hefei 230001, Anhui, Peoples R China
3.Zhengzhou Univ, Henan Int Join Lab Noncoding RNA & Metab Canc, Henan Prov & Zhengzhou City Key Lab Noncoding RNA, Acad Med Sci,Peoples Hosp, Zhengzhou 450053, Henan, Peoples R China
4.Chinese Acad Sci, Canc Hosp, Univ Chinese Acad Sci, Inst Basic Med & Canc IBMC, Hangzhou 310022, Zhejiang, Peoples R China
5.First Affiliated Hosp USTC, Anhui Prov Clin Res Ctr Hepatobiliary Dis, Hefei 230001, Anhui, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Ben,Thorne, Rick Francis,Zhang, Pengfei,et al. Vanguard is a Glucose Deprivation-Responsive Long Non-Coding RNA Essential for Chromatin Remodeling-Reliant DNA Repair[J]. ADVANCED SCIENCE,2022.
APA Zhang, Ben,Thorne, Rick Francis,Zhang, Pengfei,Wu, Mian,&Liu, Lianxin.(2022).Vanguard is a Glucose Deprivation-Responsive Long Non-Coding RNA Essential for Chromatin Remodeling-Reliant DNA Repair.ADVANCED SCIENCE.
MLA Zhang, Ben,et al."Vanguard is a Glucose Deprivation-Responsive Long Non-Coding RNA Essential for Chromatin Remodeling-Reliant DNA Repair".ADVANCED SCIENCE (2022).

入库方式： OAI收割

来源：合肥物质科学研究院

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