In Situ Upregulating Heat Shock Protein 70 via Gastric Nano-Heaters for the Interference of Helicobacter pylori Infection
文献类型:期刊论文
作者 | Xia, Xin1; Yin, Zhiwei1; Yang, Yanxia1; Li, Shengkai1; Wang, Linlin1; Cai, Xinqi1; Xu, Yiting2; Ma, Chao3; Qiu, Ye1; Chen, Zhuo1 |
刊名 | ACS NANO |
出版日期 | 2022-08-22 |
ISSN号 | 1936-0851 |
关键词 | Helicobacter pylori infection antibacterial therapy magnetothermal stimulation protein regulation gastric nano-heaters |
DOI | 10.1021/acsnano.2c03911 |
通讯作者 | Chen, Zhuo(zhuochen@hnu.edu.cn) |
英文摘要 | Taking inspiration from the mechanism of Helicobacter pylori infection can lead to innovative antibacterial ways to fight antibiotics resistance. Herein, a gastric nano-heater iron- cobalt alloy shielded with graphitic shells (FeCo@G) is developed to interfere with H. pylori infection under an alternating magnetic field. FeCo@G shows a high and stable specific loss power (SLP = 534.1 W g(-1)) in the acidic environment and provides efficient magnetothermal stimulation in the stomach. Such stimulation upregulates the cytoprotective heat shock protein 70 (HSP70) in gastric epithelial cells, which antagonizes the infection of H. pylori. This finding is further supported by the transcriptomic analysis verifying the upregulation of HSP70 in the stomach. Moreover, the nanoheater shows a high inhibition rate of H. pylori in vivo with good biocompatibility; 95% of FeCo@G is excreted from the mouse's gastrointestinal tract within 12 h. In summary, FeCo@G allows magnetothermal therapy to be used in harsh gastric environments, providing an approach for the therapy against H. pylori. |
WOS关键词 | SHOCK PROTEINS ; PYLORI ; EXPRESSION ; HSP70 ; NANOPARTICLES ; ACTIVATION ; GROWTH ; BRAIN ; ACID |
资助项目 | National Key Research and Development Program of China[2020YFA0210800] ; National Natural Science Foundation of China[21522501] ; National Natural Science Foundation of China[22225401] ; Science and Technology Innovation Program of Hunan Province[2020RC4017] |
WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
语种 | 英语 |
出版者 | AMER CHEMICAL SOC |
WOS记录号 | WOS:000848459400001 |
资助机构 | National Key Research and Development Program of China ; National Natural Science Foundation of China ; Science and Technology Innovation Program of Hunan Province |
源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/131844] |
专题 | 中国科学院合肥物质科学研究院 |
通讯作者 | Chen, Zhuo |
作者单位 | 1.Hunan Univ, Coll Chem & Chem Engn, Coll Biol, Aptamer Engn Ctr Hunan Prov,State Key Lab Chemo Bi, Changsha 410082, Hunan, Peoples R China 2.Hunan Univ Sci & Technol, Sch Chem & Chem Engn, Key Lab Theoret Organ Chem & Funct Mol, Minist Educ, Xiangtan 411201, Hunan, Peoples R China 3.Hunan Univ, Coll Mat Sci & Engn, Changsha 410082, Hunan, Peoples R China 4.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Inst Basic Med & Canc IBMC, Chinese Acad Sci,Canc Hosp, Hangzhou 310022, Zhejiang, Peoples R China 5.Shanghai Jiao Tong Univ, Renji Hosp, Inst Mol Med IMM, Sch Med, Shanghai 200240, Peoples R China 6.Shanghai Jiao Tong Univ, Coll Chem & Chem Engn, Shanghai 200240, Peoples R China |
推荐引用方式 GB/T 7714 | Xia, Xin,Yin, Zhiwei,Yang, Yanxia,et al. In Situ Upregulating Heat Shock Protein 70 via Gastric Nano-Heaters for the Interference of Helicobacter pylori Infection[J]. ACS NANO,2022. |
APA | Xia, Xin.,Yin, Zhiwei.,Yang, Yanxia.,Li, Shengkai.,Wang, Linlin.,...&Tan, Weihong.(2022).In Situ Upregulating Heat Shock Protein 70 via Gastric Nano-Heaters for the Interference of Helicobacter pylori Infection.ACS NANO. |
MLA | Xia, Xin,et al."In Situ Upregulating Heat Shock Protein 70 via Gastric Nano-Heaters for the Interference of Helicobacter pylori Infection".ACS NANO (2022). |
入库方式: OAI收割
来源:合肥物质科学研究院
浏览0
下载0
收藏0
其他版本
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。