Gut microbiota: An emerging therapeutic approach of herbal medicine for prevention of colorectal cancer
文献类型：期刊论文
| 作者 | Ying, Hua-Zhong1; Xie, Wei1; Wang, Meng-Chuan1; He, Jia-Qi2; Zhang, Huan-Huan1; Yu, Chen-Huan1,3,4 |
| 刊名 | FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
 |
| 出版日期 | 2022-08-16 |
| 卷号 | 12 |
| 关键词 | intestinal homeostasis natural products chronic inflammation probiotic immunoenhancement tumor microenvironment |
| ISSN号 | 2235-2988 |
| DOI | 10.3389/fcimb.2022.969526 |
| 通讯作者 | Yu, Chen-Huan(yuchenhuan2002@163.com) |
| 英文摘要 | The gut dysbiosis has emerged as a prominent player in the pathogenesis and development of colorectal cancer (CRC), which in turn intensifies dysregulated gut microbiota composition and inflammation. Since most drugs are given orally, this dysbiosis directly and indirectly impinges the absorption and metabolism of drugs in the gastrointestinal tract, and subsequently affects the clinical outcome of patients with CRC. Herbal medicine, including the natural bioactive products, have been used traditionally for centuries and can be considered as novel medicinal sources for anticancer drug discovery. Due to their various structures and pharmacological effects, natural products have been found to improve microbiota composition, repair intestinal barrier and reduce inflammation in human and animal models of CRC. This review summarizes the chemo-preventive effects of extracts and/or compounds derived from natural herbs as the promising antineoplastic agents against CRC, and will provide innovative strategies to counteract dysregulated microbiota and improve the lives of CRC patients. |
| WOS关键词 | ULCERATIVE-COLITIS ; MICE ; BIOAVAILABILITY ; BERBERINE ; GINSENG ; RATS ; CARCINOGENESIS ; TUMORIGENESIS ; INHIBITION ; METABOLITE |
| 资助项目 | National Natural Science Foundation of China ; Zhejiang province of medical science ; [82104526] ; [2022KY917] |
| WOS研究方向 | Immunology ; Microbiology |
| 语种 | 英语 |
| WOS记录号 | WOS:000847858900001 |
| 出版者 | FRONTIERS MEDIA SA |
| 资助机构 | National Natural Science Foundation of China ; Zhejiang province of medical science |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/131846]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Yu, Chen-Huan |
| 作者单位 | 1.Zhejiang Acad Med Sci, Hangzhou Med Coll, Key Lab Expt Anim & Safety Evaluat, Hangzhou, Peoples R China 2.Zhejiang Chinese Med Univ, Affiliated Hosp 1, Hangzhou, Peoples R China 3.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Hangzhou, Peoples R China 4.Chinese Acad Sci, Inst Canc & Basic Med, Hangzhou, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ying, Hua-Zhong,Xie, Wei,Wang, Meng-Chuan,et al. Gut microbiota: An emerging therapeutic approach of herbal medicine for prevention of colorectal cancer[J]. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY,2022,12. |
| APA | Ying, Hua-Zhong,Xie, Wei,Wang, Meng-Chuan,He, Jia-Qi,Zhang, Huan-Huan,&Yu, Chen-Huan.(2022).Gut microbiota: An emerging therapeutic approach of herbal medicine for prevention of colorectal cancer.FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY,12. |
| MLA | Ying, Hua-Zhong,et al."Gut microbiota: An emerging therapeutic approach of herbal medicine for prevention of colorectal cancer".FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY 12(2022). |
入库方式： OAI收割
来源：合肥物质科学研究院
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