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Analysis of volatile organic compounds from deep airway in the lung through intubation sampling

文献类型：期刊论文

作者Xu, Wei2,3; Zhang, Jin1; Ding, Houwen1; Ding, Yueting1; Zou, Xue2; Yang, Min1; Zhou, Qiang1; Liu, Zhou1; Zheng, Ling1; Zuo, Heping1
刊名ANALYTICAL AND BIOANALYTICAL CHEMISTRY
出版日期2022-08-26
ISSN号1618-2642
关键词VOCs Exhaled breath Intubation Deep airway PTR-MS
DOI10.1007/s00216-022-04295-x
通讯作者Zou, Xue(xzou@cmpt.ac.cn) ; Yang, Min(yangmin@ahmu.edu.cn) ; Shen, Chengyin(chyshen@aiofm.ac.cn)
英文摘要Exhaled volatile organic compounds (VOCs) have been widely applied for the study of disease biomarkers. Oral exhalation and nasal exhalation are two of the most common sampling methods. However, VOCs released from food residues and bacteria in the mouth or upper respiratory tract were also sampled and usually mistaken as that produced from body metabolism. In this study, exhalation from deep airway was first directly collected through intubation sampling and analyzed. The exhalation samples of 35 subjects were collected through a catheter, which was inserted into the trachea or bronchus through the mouth and upper respiratory tract. Then, the VOCs in these samples were detected by proton transfer reaction mass spectrometry (PTR-MS). In addition, fast gas chromatography proton transfer reaction mass spectrometry (FGC-PTR-MS) was used to further determine the VOCs with the same mass-to-charge ratios. The results showed that there was methanol, acetonitrile, ethanol, methyl mercaptan, acetone, isoprene, and phenol in the deep airway. Compared with that in oral exhalation, ethanol, methyl mercaptan, and phenol had lower concentrations. In detail, the median concentrations of ethanol, methyl mercaptan, and phenol were 7.3, 0.6, and 23.9 ppbv, while those in the oral exhalation were 80.0, 5.1, and 71.3 ppbv, respectively, which meant the three VOCs mainly originated from the food residues and bacteria in the mouth or upper respiratory tract, rather than body metabolism. The research results in our study can provide references for expiratory VOC research based on oral and nasal exhalation samplings, which are more feasible in clinical practice.
WOS关键词EXHALED BREATH ; MASS-SPECTROMETRY ; CANCER ; BIOMARKERS ; MARKERS ; QUANTIFICATION ; ESOPHAGEAL ; DIAGNOSIS ; ACETONE
资助项目National Natural Science Foundation of China[22076190] ; National Natural Science Foundation of China[21876176] ; National Natural Science Foundation of China[62171433] ; National Natural Science Foundation of China[21705152] ; Youth Innovation Promotion Association, CAS, China[2019432] ; Second Affiliated Hospital of Anhui Medical University[LHJJ2020006] ; Center of Medical Physics and Technology of Hefei Institute of Physical Sciences of Chinese Academy of Sciences[LHJJ2020006] ; HFIPS Director's Fund[BJPY2021B08] ; HFIPS Director's Fund[YZJJ2022QN45] ; HFIPS Director's Fund[YZJJZX202009] ; Anhui Provincial Key RD Program[202104d07020003]
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
语种英语
出版者SPRINGER HEIDELBERG
WOS记录号WOS:000844909900001
资助机构National Natural Science Foundation of China ; Youth Innovation Promotion Association, CAS, China ; Second Affiliated Hospital of Anhui Medical University ; Center of Medical Physics and Technology of Hefei Institute of Physical Sciences of Chinese Academy of Sciences ; HFIPS Director's Fund ; Anhui Provincial Key RD Program
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/131850]  
专题中国科学院合肥物质科学研究院
通讯作者Zou, Xue; Yang, Min; Shen, Chengyin
作者单位1.Anhui Med Univ, Hosp 2, Hefei 230601, Peoples R China
2.Chinese Acad Sci, Inst Hlth & Med Technol, Hefei Inst Phys Sci, Anhui Prov Key Lab Med Phys & Technol, Hefei 230031, Peoples R China
3.Univ Sci & Technol China, Hefei 230026, Peoples R China
4.Chinese Acad Sci, Hefei Canc Hosp, Hefei 230031, Peoples R China
推荐引用方式
GB/T 7714		 Xu, Wei,Zhang, Jin,Ding, Houwen,et al. Analysis of volatile organic compounds from deep airway in the lung through intubation sampling[J]. ANALYTICAL AND BIOANALYTICAL CHEMISTRY,2022.
APA Xu, Wei.,Zhang, Jin.,Ding, Houwen.,Ding, Yueting.,Zou, Xue.,...&Chu, Yannan.(2022).Analysis of volatile organic compounds from deep airway in the lung through intubation sampling.ANALYTICAL AND BIOANALYTICAL CHEMISTRY.
MLA Xu, Wei,et al."Analysis of volatile organic compounds from deep airway in the lung through intubation sampling".ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2022).

入库方式： OAI收割

来源：合肥物质科学研究院

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