Clinical analysis of 13 cases of primary squamous-cell thyroid carcinoma
文献类型：期刊论文
| 作者 | Ou, Di5,6; Ni, Chen4; Yao, Jincao6; Lai, Min4; Chen, Chen3; Zhang, Yajiao4; Jiang, Tian2; Qian, Tingting4; Wang, Liping6; Xu, Dong1,5 |
| 刊名 | FRONTIERS IN ONCOLOGY
 |
| 出版日期 | 2022-08-16 |
| 卷号 | 12 |
| ISSN号 | 2234-943X |
| 关键词 | thyroid primary squamous-cell thyroid carcinoma thyroid carcinoma ultrasound pathological features |
| DOI | 10.3389/fonc.2022.956289 |
| 通讯作者 | Wang, Liping(wanglp@zjcc.org.cn) ; Xu, Dong(xudong@zjcc.org.cn) |
| 英文摘要 | ObjectiveTo analyze the clinical features, ultrasonographic manifestations, pathological features, treatment and prognosis of primary thyroid squamous cell carcinoma (PSCTC) and summarize the experience in diagnosis and treatment of this condition. MethodsA retrospective analysis was conducted on patients who were admitted to Zhejiang Cancer Hospital from 2007 to 2021 due to thyroid nodules or thyroid malignant tumors that were ultimately confirmed by postoperative pathology as primary thyroid squamous cell carcinoma. We summarize the general situation, clinical information, laboratory examination, ultrasonic image characteristics, pathological examination, clinical treatment and prognosis of the patients. ResultsPSCTC is most often seen in older men and progresses rapidly. In laboratory tests, some patients had elevated levels of tumor markers (CA199, squamous cell carcinoma antigen level), thyroglobulin levels and tumor-related substances, but all these indicators lacked specificity. The ultrasound features of PSCTC are mainly hypoechoic, hard, substantial nodules with gross borders and a grade 1-2 blood flow signal, sometimes with signs of necrosis and calcification. In terms of treatment, PSCTC is mainly surgically resected, though some patients in this study underwent iodine-131 radiation therapy, local radiotherapy, and chemotherapy with unclear results. None of the patients survived for very long after treatment, but the prognosis of patients with highly differentiated squamous carcinoma was significantly better than that of patients with poorly differentiated squamous carcinoma. Papillary thyroid carcinoma may be one of the causes of PSCTC. ConclusionPSCTC is a malignant tumor with high malignancy and rapid clinical progression. Treatment options are mainly based on surgical resection and can be supplemented with radiotherapy and chemotherapy, but there is still a lack of a standardized treatment management system, and more cases and reports are needed to accumulate data. |
| WOS关键词 | GLAND |
| 资助项目 | National Natural Science Foundation of China[82071946] ; Zhejiang Provincial Natural Science Foundation[LZY21F030001] ; Zhejiang Provincial Medical and Health Science and Technology Program Project[2021KY099] ; Zhejiang Province Science and Technology Plan of Traditional Chinese Medicine[2020ZB033] ; Zhejiang Provincial Natural Science Foundation of China[LY20H180001] |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| 出版者 | FRONTIERS MEDIA SA |
| WOS记录号 | WOS:000848031400001 |
| 资助机构 | National Natural Science Foundation of China ; Zhejiang Provincial Natural Science Foundation ; Zhejiang Provincial Medical and Health Science and Technology Program Project ; Zhejiang Province Science and Technology Plan of Traditional Chinese Medicine ; Zhejiang Provincial Natural Science Foundation of China |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/131890]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Wang, Liping; Xu, Dong |
| 作者单位 | 1.Chinese Acad Sci, Inst Basic Med & Canc, Hangzhou, Peoples R China 2.Wen Zhou Med Univ, Postgrad Training Base, Hangzhou, Peoples R China 3.Wannan Med Coll, Grad Sch, Hangzhou, Peoples R China 4.Zhejiang Chinese Med Univ, Clin Med Coll 2, Hangzhou, Peoples R China 5.Key Lab Head & Neck Canc Translat Res Zhejiang Pro, Hangzhou, Peoples R China 6.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Inst Basic Med & Canc IBMC, Chinese Acad Sci,Canc Hosp, Hangzhou, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ou, Di,Ni, Chen,Yao, Jincao,et al. Clinical analysis of 13 cases of primary squamous-cell thyroid carcinoma[J]. FRONTIERS IN ONCOLOGY,2022,12. |
| APA | Ou, Di.,Ni, Chen.,Yao, Jincao.,Lai, Min.,Chen, Chen.,...&Xu, Dong.(2022).Clinical analysis of 13 cases of primary squamous-cell thyroid carcinoma.FRONTIERS IN ONCOLOGY,12. |
| MLA | Ou, Di,et al."Clinical analysis of 13 cases of primary squamous-cell thyroid carcinoma".FRONTIERS IN ONCOLOGY 12(2022). |
入库方式： OAI收割
来源：合肥物质科学研究院
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