PB1F2 from Influenza A Virus Regulates the Interaction between Cytochrome C and Cardiolipin
文献类型：期刊论文
| 作者 | Wang, Yujuan2 ; Wang, Junfeng1,2
|
| 刊名 | MEMBRANES
 |
| 出版日期 | 2022-08-01 |
| 卷号 | 12 |
| 关键词 | PB1F2 cytochrome c cardiolipin liposome nanodisc |
| DOI | 10.3390/membranes12080795 |
| 通讯作者 | Wang, Yujuan(yjwang@hmfl.ac.cn) ; Wang, Junfeng(junfeng@hmfl.ac.cn) |
| 英文摘要 | PB1F2 is a membrane associated protein encoded by the influenza virus gene in the host. Similar to endogenous pro-apoptotic proteins, it acts on the mitochondria of the host immune cells, inducing apoptosis of the cells. The PB1F2 protein has been demonstrated to facilitate the release of cytochrome c in addition to impairing the integrity of the inner mitochondrial membrane. This investigation focused on how the protein PB1F2 interacted with cardiolipin and cytochrome c. The regulation of PB1F2 on the binding of cytochrome c to cardiolipin in two kinds of in vitro membrane mimics was investigated by biophysical techniques. PB1F2 aids in the dissociation of cytochrome c-cardiolipin complexes in liposomes and nanodiscs. The results provide novel explanations and evidence for how PB1F2 functions as a viral virulence factor by inducing immune cell death. |
| WOS关键词 | MITOCHONDRIAL PROTEIN ; PB1-F2 PROTEIN ; MEMBRANE ; BINDING ; OLIGOMERIZATION ; PATHOGENICITY ; NANODISCS ; TRIGGER |
| 资助项目 | National Natural Science Foundation of China[21473210] ; Users with Excellence Program of Hefei Science Center, CAS[2020HSC-UE018] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry ; Engineering ; Materials Science ; Polymer Science |
| 语种 | 英语 |
| 出版者 | MDPI |
| WOS记录号 | WOS:000846512500001 |
| 资助机构 | National Natural Science Foundation of China ; Users with Excellence Program of Hefei Science Center, CAS |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/131906]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Wang, Yujuan; Wang, Junfeng |
| 作者单位 | 1.Anhui Univ, Inst Phys Sci, Hefei 230601, Peoples R China 2.Chinese Acad Sci, Hefei Inst Phys Sci, High Magnet Field Lab, CAS Key Lab High Magnet Field & Ion Beam Phys Bio, Hefei 230031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Yujuan,Wang, Junfeng. PB1F2 from Influenza A Virus Regulates the Interaction between Cytochrome C and Cardiolipin[J]. MEMBRANES,2022,12. |
| APA | Wang, Yujuan,&Wang, Junfeng.(2022).PB1F2 from Influenza A Virus Regulates the Interaction between Cytochrome C and Cardiolipin.MEMBRANES,12. |
| MLA | Wang, Yujuan,et al."PB1F2 from Influenza A Virus Regulates the Interaction between Cytochrome C and Cardiolipin".MEMBRANES 12(2022). |
入库方式： OAI收割
来源：合肥物质科学研究院
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