Sheep tail fat inhibits the proliferation of non-small-cell lung cancer cells in vitro and in vivo
文献类型：期刊论文
| 作者 | Xu, Changzhi4; Zhang, Lanlan4; He, Huimin4; Liu, Xiaoyi4; Pei, Xinxin4; Ma, Tengfei2,3; Ma, Bingbing2,3; Lin, Wenchu1; Zhang, Buchang4 |
| 刊名 | FRONTIERS IN PHARMACOLOGY
 |
| 出版日期 | 2022-08-11 |
| 卷号 | 13 |
| 关键词 | sheep tail fat non-small-cell lung cancer heptadecanoic acid antiproliferative effect Akt S6K signaling pathway |
| DOI | 10.3389/fphar.2022.917513 |
| 通讯作者 | Lin, Wenchu(wenchu@hmfl.ac.cn) ; Zhang, Buchang(zhbc@ahu.edu.cn) |
| 英文摘要 | Increasing evidence suggests that numerous edible oils may function as adjuvant dietary therapies to treat cancer. We previously reported that the odd-chain saturated fatty acid (OCSFA), heptadecanoic acid (C17:0), profoundly inhibits non-small-cell lung cancer (NSCLC) cell proliferation. However, the antitumor potential of edible lipids rich in C17:0 remains unclear. Here, we determined that sheep tail fat (STF) is a dietary lipid rich in C17:0 and exhibited the greatest inhibitory effect against three NSCLC cell lines (A549, PC-9, and PC-9/GR) among common dietary lipids. Cell migration experiments demonstrated that STF could significantly inhibit the wound healing capacity of three NSCLC cell lines by promoting the generation of reactive oxygen species (ROS) and subsequent cell death. Mechanistic studies showed that STF suppressed NSCLC cell growth by downregulating the Akt/S6K signaling pathway. Furthermore, administration of STF reduced tumor growth, weight, and expression of the proliferative marker Ki-67 in nude mice bearing A549 xenografts. Collectively, our data show that STF has antitumor activity against NSCLC, implying that dietary intake of C17:0-rich STF may be a potential adjuvant therapy for NSCLC. |
| WOS关键词 | CORONARY-HEART-DISEASE ; DIETARY ; ACID ; RISK ; ASSOCIATION ; MECHANISMS ; RESISTANCE ; ANTITUMOR ; HEALTH ; LIFE |
| 资助项目 | Science and Technology Major Project of Anhui Province, China ; innovation and entrepreneurship project of high-level scientific and technological talent teams in Anhui Province[202003a06020026] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | FRONTIERS MEDIA SA |
| WOS记录号 | WOS:000844661100001 |
| 资助机构 | Science and Technology Major Project of Anhui Province, China ; innovation and entrepreneurship project of high-level scientific and technological talent teams in Anhui Province |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/132047]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Lin, Wenchu; Zhang, Buchang |
| 作者单位 | 1.Chinese Acad Sci, High Magnet Field Lab, Hefei, Anhui, Peoples R China 2.Fuyang Tianxiang Food Technol Co Ltd, Fuyang, Anhui, Peoples R China 3.Anhui Tianxiang Grain & Oil Food Co Ltd, Fuyang, Anhui, Peoples R China 4.Anhui Univ, Inst Phys Sci & Informat Technol, Hefei, Anhui, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Changzhi,Zhang, Lanlan,He, Huimin,et al. Sheep tail fat inhibits the proliferation of non-small-cell lung cancer cells in vitro and in vivo[J]. FRONTIERS IN PHARMACOLOGY,2022,13. |
| APA | Xu, Changzhi.,Zhang, Lanlan.,He, Huimin.,Liu, Xiaoyi.,Pei, Xinxin.,...&Zhang, Buchang.(2022).Sheep tail fat inhibits the proliferation of non-small-cell lung cancer cells in vitro and in vivo.FRONTIERS IN PHARMACOLOGY,13. |
| MLA | Xu, Changzhi,et al."Sheep tail fat inhibits the proliferation of non-small-cell lung cancer cells in vitro and in vivo".FRONTIERS IN PHARMACOLOGY 13(2022). |
入库方式： OAI收割
来源：合肥物质科学研究院
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