Injectable magnetic montmorillonite colloidal gel for the postoperative treatment of hepatocellular carcinoma
文献类型:期刊论文
作者 | Chen, Sheng4; Song, Yonghong4; Yan, Xu4; Dong, Liang1,3; Xu, Yunjun3; Xuan, Shouhu3; Shu, Quan3; Cao, Baoqiang2; Hu, Jinlong2; Xing, Hanye4 |
刊名 | JOURNAL OF NANOBIOTECHNOLOGY |
出版日期 | 2022-08-19 |
卷号 | 20 |
关键词 | Colloidal gel Magnetic hyperthermia Hepatocellular carcinoma Postoperative therapy Hemostasis |
DOI | 10.1186/s12951-022-01559-7 |
通讯作者 | Dong, Liang(dldisc@ustc.edu.cn) ; Zha, Zhengbao(zbzha@hfut.edu.cn) ; Lu, Yang(yanglu@hfut.edu.cn) |
英文摘要 | Bioactive materials have been extensively developed for the adjuvant therapy of cancer. However, few materials can meet the requirements for the postoperative resection of hepatocellular carcinoma (HCC) due to massive bleeding and high recurrence. In particular, combination therapy for HCC has been highly recommended in clinical practice, including surgical resection, interventional therapy, ablation therapy and chemotherapy. Herein, an injectable magnetic colloidal gel (MCG) was developed by controllable electrostatic attraction between clinically available magnetic montmorillonites and amphoteric gelatin nanoparticles. The optimized MCG exhibited an effective magnetic heating effect, remarkable rheological properties, and high gel network stability, realizing the synergistic treatment of postoperative HCC by stimuli-responsive drug delivery, hemostasis and magnetic hyperthermia. Furthermore, a minimal invasive MCG-induced interventional magnetic hyperthermia therapy (MHT) under ultrasound guidance was realized on hepatic tumor rabbits, providing an alternative therapeutics to treat the postoperative recurrence. Overall, MCG is a clinically available injectable formulation for adjuvant therapy after HCC surgical resection. |
WOS关键词 | GELATIN NANOSPHERES ; CANCER ; THERMOTHERAPY ; RECURRENCE ; SURGERY |
资助项目 | National Natural Science Foundation of China[51972090] ; National Natural Science Foundation of China[22122502] ; National Natural Science Foundation of China[22105195] ; National Natural Science Foundation of China[51702309] ; National Natural Science Foundation of China[51572067] ; National Natural Science Foundation of China[21501039] ; Fundamental Research Funds for the Central Universities[JZ2021HGPB0059] ; Fundamental Research Funds for the Central Universities[JZ2021HGQB0279] ; Fundamental Research Funds for the Central Universities[WK2060000033] ; Fundamental Research Funds for the Central Universities[WK9110000062] ; Anhui Provincial Natural Science Foundation[2008085J06] ; University Synergy Innovation Program of Anhui Province[GXXT-2020-063] ; University Synergy Innovation Program of Anhui Province[GXXT-2021066] ; China Postdoctoral Science Foundation[BH2060000173] ; National Key Research and Development Program of China[2018YFE0202201] |
WOS研究方向 | Biotechnology & Applied Microbiology ; Science & Technology - Other Topics |
语种 | 英语 |
出版者 | BMC |
WOS记录号 | WOS:000843254600002 |
资助机构 | National Natural Science Foundation of China ; Fundamental Research Funds for the Central Universities ; Anhui Provincial Natural Science Foundation ; University Synergy Innovation Program of Anhui Province ; China Postdoctoral Science Foundation ; National Key Research and Development Program of China |
源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/132053] |
专题 | 中国科学院合肥物质科学研究院 |
通讯作者 | Dong, Liang; Zha, Zhengbao; Lu, Yang |
作者单位 | 1.Chinese Acad Sci, Univ Chinese Acad Sci, Zhejiang Canc Hosp, Inst Basic Med & Canc IBMC,Canc Hosp, Hangzhou 310022, Zhejiang, Peoples R China 2.Anhui 2 Prov Peoples Hosp, Dept Gen Surg, Dept Ultrason, Dept Intervent Radiol, Hefei 230041, Anhui, Peoples R China 3.Univ Sci & Technol China, Affiliated Hosp 1, Dept Modern Mech, Div Nanomat & Chem,Dept Radiol,Hefei Natl Lab Phy, Hefei 230026, Peoples R China 4.Hefei Univ Technol, Sch Chem & Chem Engn, Sch Food & Biol Engn, Anhui Key Lab Adv Catalyt Mat & React Engn, Hefei 230009, Peoples R China |
推荐引用方式 GB/T 7714 | Chen, Sheng,Song, Yonghong,Yan, Xu,et al. Injectable magnetic montmorillonite colloidal gel for the postoperative treatment of hepatocellular carcinoma[J]. JOURNAL OF NANOBIOTECHNOLOGY,2022,20. |
APA | Chen, Sheng.,Song, Yonghong.,Yan, Xu.,Dong, Liang.,Xu, Yunjun.,...&Lu, Yang.(2022).Injectable magnetic montmorillonite colloidal gel for the postoperative treatment of hepatocellular carcinoma.JOURNAL OF NANOBIOTECHNOLOGY,20. |
MLA | Chen, Sheng,et al."Injectable magnetic montmorillonite colloidal gel for the postoperative treatment of hepatocellular carcinoma".JOURNAL OF NANOBIOTECHNOLOGY 20(2022). |
入库方式: OAI收割
来源:合肥物质科学研究院
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