Real-Time MRI Monitoring of GelMA-Based Hydrogel-Loaded Kartogenin for In Situ Cartilage Regeneration
文献类型：期刊论文
| 作者 | Zhang, Hanyuan5,6,7; Fang, Weijun4; Zhao, Tingting4; Zhang, Huabing4; Gao, Liang2,3; Li, Jingya6,7; Wang, Rujing7 ; Xu, Weiping1,6,7
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| 刊名 | FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
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| 出版日期 | 2022-07-22 |
| 卷号 | 10 |
| 关键词 | kartogenin cartilage regeneration dopamine magnetic resonance imaging (MRI) hydrogels |
| ISSN号 | 2296-4185 |
| DOI | 10.3389/fbioe.2022.940735 |
| 通讯作者 | Xu, Weiping(weipingx@ustc.edu.cn) |
| 英文摘要 | The cartilage has poor ability to mount a sufficient healing response. Herein, kartogenin (KGN), an emerging stable non-protein compound with the ability to recruit bone marrow mesenchyme stem cells (BMSCs) to promote chondrogenic differentiation, was grafted onto dopamine-Fe(III) chelating nanoparticles, followed by involving a gelatin- and dextran-based injectable hydrogel to mimic the extracellular matrix to promote cartilage repair. The in vitro results demonstrated that KGN underwent long-term sustained release behavior and availably promoted the deep migration of BMSC cells in yielding hydrogels. Furthermore, in vivo New Zealand white rabbits' cartilage defect model repairing results showed that cartilage defect obtained significant regeneration post operation in the 12th week, and the defect edge almost disappeared compared to adjacent normal cartilage tissue. Meanwhile, the T-2-weighted magnetic resonance imaging (MRI) property resulting from dissociative Fe (III) can significantly monitor the degradation degree of the implanted hydrogels in the defect site. This integrated diagnosis and treatment system gives insight into cartilage regeneration. |
| WOS关键词 | HYALURONIC-ACID ; SCAFFOLDS ; COLLAGEN ; GELATIN ; REPAIR |
| 资助项目 | National Natural Science Foundation of China[52072360] ; National Natural Science Foundation of China[51672004] ; Key Research and Development Program of Anhui Province (China)[1804h08020252] ; Natural Science Foundation of Anhui Province (China)[1608085MH176] ; Natural Science Foundation of Anhui Province (China)[1908085QB65] |
| WOS研究方向 | Biotechnology & Applied Microbiology ; Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000837103200001 |
| 出版者 | FRONTIERS MEDIA SA |
| 资助机构 | National Natural Science Foundation of China ; Key Research and Development Program of Anhui Province (China) ; Natural Science Foundation of Anhui Province (China) |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/132161]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Xu, Weiping |
| 作者单位 | 1.Univ Sci & Technol China, Affiliated Hosp 1, Div Life Sci & Med, USTC, Hefei, Peoples R China 2.Sino Euro Orthopaed Network, Berlin, Germany 3.Hua Tuo Inst Med Innovat HTIMI, Wuhan, Peoples R China 4.Anhui Med Univ, Sch Basic Med Sci, Hefei, Peoples R China 5.Anhui Med Univ, Dept Orthoped, Affiliated Hosp 1, Hefei, Peoples R China 6.Univ Sci & Technol China, Dept Biol Phys, Hefei, Peoples R China 7.Chinese Acad Sci, Inst Intelligent Machines, Hefei, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Hanyuan,Fang, Weijun,Zhao, Tingting,et al. Real-Time MRI Monitoring of GelMA-Based Hydrogel-Loaded Kartogenin for In Situ Cartilage Regeneration[J]. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY,2022,10. |
| APA | Zhang, Hanyuan.,Fang, Weijun.,Zhao, Tingting.,Zhang, Huabing.,Gao, Liang.,...&Xu, Weiping.(2022).Real-Time MRI Monitoring of GelMA-Based Hydrogel-Loaded Kartogenin for In Situ Cartilage Regeneration.FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY,10. |
| MLA | Zhang, Hanyuan,et al."Real-Time MRI Monitoring of GelMA-Based Hydrogel-Loaded Kartogenin for In Situ Cartilage Regeneration".FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY 10(2022). |
入库方式： OAI收割
来源：合肥物质科学研究院
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