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Microbiome Resilience and Health Implications for People in Half-Year Travel

文献类型：期刊论文

作者Cheng, Mingyue4; Liu, Hong4,5; Han, Maozhen4; Li, Shuai Cheng3; Bu, Dongbo1,2; Sun, Shiwei1,2; Hu, Zhiqiang5; Yang, Pengshuo4; Wang, Rui5; Liu, Yawen5
刊名FRONTIERS IN IMMUNOLOGY
出版日期2022-02-24
卷号13页码:15
ISSN号1664-3224
关键词travel enterotype microbiome bi-directional plasticity resilience dietary shift immunity health
DOI10.3389/fimmu.2022.848994
英文摘要Travel entail change in geography and diet, both of which are known as determinant factors in shaping the human gut microbiome. Additionally, altered gut microbiome modulates immunity, bringing about health implications in humans. To explore the effects of the mid-term travel on the gut microbiome, we generated 16S rRNA gene and metagenomic sequencing data from longitudinal samples collected over six months. We monitored dynamic trajectories of the gut microbiome variation of a Chinese volunteer team (VT) in their whole journey to Trinidad and Tobago (TAT). We found gut microbiome resilience that VT's gut microbial compositions gradually transformed to the local TAT's enterotypes during their six-month stay in TAT, and then reverted to their original enterotypes after VT's return to Beijing in one month. Moreover, we identified driven species in this bi-directional plasticity that could play a role in immunity modulation, as exemplified by Bacteroides dorei that attenuated atherosclerotic lesion formation and effectively suppressed proinflammatory immune response. Another driven species P. copri could play a crucial role in rheumatoid arthritis pathogenesis, a chronic autoimmune disease. Carbohydrate-active enzymes are often implicated in immune and host-pathogen interactions, of which glycoside hydrolases were found decreased but glycosyltransferases and carbohydrate esterases increased during the travel; these functions were then restored after VT' returning to Beijing. Furthermore, we discovered these microbial changes and restoration were mediated by VT people's dietary changes. These findings indicate that half-year travel leads to change in enterotype and functional patterns, exerting effects on human health. Microbial intervention by dietary guidance in half-year travel would be conducive to immunity modulation for maintaining health.
资助项目National Natural Science Foundation of China[31871334] ; National Natural Science Foundation of China[32071465] ; National Natural Science Foundation of China[31671374] ; National Natural Science Foundation of China[31327901] ; National Natural Science Foundation of China[31671369] ; National Natural Science Foundation of China[31770775] ; National Natural Science Foundation of China[61521092] ; National Natural Science Foundation of China[91430218] ; National Natural Science Foundation of China[61472395] ; National Natural Science Foundation of China[61432018] ; National Key Research and Development Program of China[2018YFC0910502] ; National Key Research and Development Program of China[2018YFC0910405] ; GRF Research Project[9042348] ; GRF Research Project[CityU11257316]
WOS研究方向Immunology
语种英语
出版者FRONTIERS MEDIA SA
WOS记录号WOS:000768026900001
源URL[http://119.78.100.204/handle/2XEOYT63/18948]  
专题中国科学院计算技术研究所期刊论文_英文
通讯作者Wu, Jing; Tan, Guangming; Ning, Kang
作者单位1.Chinese Acad Sci, Key Lab Intelligent Informat Proc, State Lab Comp Architecture, Inst Comp Technol, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Sch Comp & Control, Beijing, Peoples R China
3.City Univ Hong Kong, Dept Comp Sci, Hong Kong, Peoples R China
4.Huazhong Univ Sci & Technol, Key Lab Mol Biophys, Minist Educ,Dept Bioinformat & Syst Biol,Coll Lif, Hubei Key Lab Bioinformat & Mol Imaging,Ctr AI Bi, Wuhan, Peoples R China
5.Capital Med Univ, Beijing Shijitan Hosp, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Cheng, Mingyue,Liu, Hong,Han, Maozhen,et al. Microbiome Resilience and Health Implications for People in Half-Year Travel[J]. FRONTIERS IN IMMUNOLOGY,2022,13:15.
APA Cheng, Mingyue.,Liu, Hong.,Han, Maozhen.,Li, Shuai Cheng.,Bu, Dongbo.,...&Ning, Kang.(2022).Microbiome Resilience and Health Implications for People in Half-Year Travel.FRONTIERS IN IMMUNOLOGY,13,15.
MLA Cheng, Mingyue,et al."Microbiome Resilience and Health Implications for People in Half-Year Travel".FRONTIERS IN IMMUNOLOGY 13(2022):15.

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来源：计算技术研究所

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