Inhibition of angiogenesis by chitooligosaccharides with specific degrees of acetylation and polymerization
文献类型：期刊论文
| 作者 | Wu, Haige1,3; Aam, Berit B.2; Wang, Wenxia1; Norberg, Anne Line2; Sorlie, Morten2; Eijsink, Vincent G. H.2; Du, Yuguang1 |
| 刊名 | carbohydrate polymers
 |
| 出版日期 | 2012-06-20 |
| 卷号 | 89期号:2页码:511-518 |
| 关键词 | Chitooligosaccharides (CHOS) Anti-angiogenesis Chitin Chitosan Chitinase Chitosanase |
| ISSN号 | 2270-2278 |
| 产权排序 | 1,1 |
| 通讯作者 | 杜昱光 |
| 英文摘要 | chitooligosaccharides (chos) inhibit angiogenesis and may be used in the treatment of cancer tumors. we have studied the effect of the fraction of acetylation (f-a) and the degree of polymerization (dp) on chos anti-angiogenic activity. we tested enzymatically produced chos-mixtures with f(a)0.15, f(a)0.3 and f(a)0.6, and dp <= 12 in initial experiments with chorioallantoic membranes. all of the samples reduced the formation of new blood vessels, chos with f(a)0.3 giving the best effect. single-dp fractions from the f(a)0.3 sample purified by size-exclusion chromatography (dp3-dp12) were then tested for inhibition of migration of human endothelial cells, which is an important element of the angiogenesis process. all of the fractions inhibited migration, meaning that, within the dp area tested in this study, f-a is more important than dp for the effect. generally, the results reveal that dp3-dp12 chos have considerable potential as anti-angiogenic compounds. (c) 2012 elsevier ltd. all rights reserved. |
| WOS标题词 | science & technology ; physical sciences |
| 学科主题 | 物理化学 |
| 类目[WOS] | chemistry, applied ; chemistry, organic ; polymer science |
| 研究领域[WOS] | chemistry ; polymer science |
| 关键词[WOS] | deacetylated chitins chitosans ; streptomyces-coelicolor a3(2) ; field nmr-spectroscopy ; serratia-marcescens ; in-vitro ; cells ; degradation ; mechanism ; oligosaccharides ; processivity |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000304632900029 |
| 公开日期 | 2013-10-11 |
| 源URL | [http://159.226.238.44/handle/321008/118140]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China 2.Norwegian Univ Life Sci, Dept Chem Biotechnol & Food Sci, N-1432 As, Norway 3.Dalian Univ Technol, Bioengn Coll, Dalian 116622, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Haige,Aam, Berit B.,Wang, Wenxia,et al. Inhibition of angiogenesis by chitooligosaccharides with specific degrees of acetylation and polymerization[J]. carbohydrate polymers,2012,89(2):511-518. |
| APA | Wu, Haige.,Aam, Berit B..,Wang, Wenxia.,Norberg, Anne Line.,Sorlie, Morten.,...&Du, Yuguang.(2012).Inhibition of angiogenesis by chitooligosaccharides with specific degrees of acetylation and polymerization.carbohydrate polymers,89(2),511-518. |
| MLA | Wu, Haige,et al."Inhibition of angiogenesis by chitooligosaccharides with specific degrees of acetylation and polymerization".carbohydrate polymers 89.2(2012):511-518. |
入库方式： OAI收割
来源：大连化学物理研究所
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