中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 心理研究所
  3. 中国科学院心理研究所
  4. 中国科学院心理健康重点实验室
The main effect and gene-environment interaction effect of the ADCYAP1R1 polymorphism rs2267735 on the course of posttraumatic stress disorder symptoms-A longitudinal analysis

文献类型：期刊论文

作者Zhang, Jingyi3,4,5; Li, Gen3,4,5; Yang, Haibo2; Cao, Chengqi3,4,5; Fang, Ruojiao3,4,5; Liu, Ping1; Luo, Shu1; Zhao, Guangyi3,4,5; Zhang, Yingqian3,4,5; Zhang, Kunlin3,4,5
刊名FRONTIERS IN PSYCHIATRY
出版日期2022-10-28
卷号13页码:11
ISSN号1664-0640
关键词posttraumatic stress disorder SNP gene-environment interaction longitudinal analysis
DOI10.3389/fpsyt.2022.1032837
通讯作者Zhang, Kunlin(zhangkl@psych.ac.cn) ; Wang, Li(wangli1@psych.ac.cn)
英文摘要BackgroundMany studies have been performed to investigate the association between the ADCYAP1R1 polymorphism rs2267735 and posttraumatic stress disorder (PTSD), but the results have been inconsistent, and the way in which this gene affects the course of PTSD has not been widely investigated. Thus, a longitudinal study of the course (development trajectory) of PTSD is needed. MethodsIn this study, we performed a longitudinal analysis of rs2267735 in 1017 young, trauma-exposed Chinese people (549 females and 468 males, ranging from 7 to 11 years old). At four time points after trauma exposure (2.5, 3.5, 4.5, and 5.5 years), we measured PTSD symptoms with the University of California, Los Angeles PTSD Reaction Index (PTSD-RI) for DSM-IV (Child Version). We employed a latent growth model (LGM) for the longitudinal data to test the association between rs2267735 (main and gene-environment interaction effects) and the course of PTSD symptoms. ResultsThe results of LGM showed that the gene-environment interaction (rs2267735 x trauma exposure) effects were associated with PTSD symptoms in girls at 2.5 years (beta = -0.291 and P = 0.013 for LGM intercept). The gene-environment interaction (rs2267735 x trauma exposure) effect was also correlated with PTSD symptoms in girls at 3.5 and 4.5 years (beta = -0.264 and P = 0.005; beta = -0.217 and P = 0.013). ConclusionOur study revealed that the gene-environment interaction of the ADCYAP1R1 polymorphism rs2267735 is associated with PTSD symptoms in girls at 2.5 years and that the effects may be stable over time and not related to the PTSD symptom recovery rate. This is the first study to detect the how the ADCYAP1R1 gene affects the course of PTSD after trauma exposure in a longitudinal view.
收录类别SCI
WOS关键词ESTROGEN-RECEPTORS ; TRAUMA EXPOSURE ; MENTAL-HEALTH ; ASSOCIATION ; CHILDREN ; PACAP ; EARTHQUAKE ; SURVIVORS ; GENOTYPE ; TRAJECTORIES
资助项目National Natural Science Foundation of China[U21A20364] ; National Natural Science Foundation of China[31971020] ; National Natural Science Foundation of China[82174237] ; Key Project of the National Social Science Foundation of China[20ZDA079] ; Key Project of Research Base of Humanities and Social Sciences of Ministry of Education[16JJD190006] ; Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences[E2CX4115CX]
WOS研究方向Psychiatry
语种英语
出版者FRONTIERS MEDIA SA
WOS记录号WOS:000884918800001
资助机构National Natural Science Foundation of China ; Key Project of the National Social Science Foundation of China ; Key Project of Research Base of Humanities and Social Sciences of Ministry of Education ; Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences
源URL[http://ir.psych.ac.cn/handle/311026/43918]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Zhang, Kunlin; Wang, Li
作者单位1.Peoples Hosp Deyang City, Deyang, Sichuan, Peoples R China
2.Tianjin Normal Univ, Acad Psychol & Behav, Tianjin, Peoples R China
3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
4.Chinese Acad Sci, Inst Psychol, Ctr Genet & Biomed Informat Res, CAS Key Lab Mental Hlth, Beijing, Peoples R China
5.Chinese Acad Sci, Inst Psychol, Lab Traumat Stress Studies, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Jingyi,Li, Gen,Yang, Haibo,et al. The main effect and gene-environment interaction effect of the ADCYAP1R1 polymorphism rs2267735 on the course of posttraumatic stress disorder symptoms-A longitudinal analysis[J]. FRONTIERS IN PSYCHIATRY,2022,13:11.
APA Zhang, Jingyi.,Li, Gen.,Yang, Haibo.,Cao, Chengqi.,Fang, Ruojiao.,...&Wang, Li.(2022).The main effect and gene-environment interaction effect of the ADCYAP1R1 polymorphism rs2267735 on the course of posttraumatic stress disorder symptoms-A longitudinal analysis.FRONTIERS IN PSYCHIATRY,13,11.
MLA Zhang, Jingyi,et al."The main effect and gene-environment interaction effect of the ADCYAP1R1 polymorphism rs2267735 on the course of posttraumatic stress disorder symptoms-A longitudinal analysis".FRONTIERS IN PSYCHIATRY 13(2022):11.

入库方式： OAI收割

来源：心理研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。