中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Effect of early embryonic exposure to morphine on defects in the GABAergic system of day-old chicks

文献类型:期刊论文

作者Wang, Dongmei4,5; Jiang, Juan4,5; Shang, Wen4,5; Zhang, Jianjun4,5; Jiang, Xiao4,5; Shen, Fang4,5; Liang, Jing4,5; Li, Yonghui4,5; Li, Ming3; Wang, Mengya2,5
刊名PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
出版日期2023-03-08
卷号121页码:9
ISSN号0278-5846
关键词Embryonic morphine exposure gamma-Aminobutyric acid Neuroelectrophysiology Intermediate medial mesopallium (IMM) Chicks Addictive susceptibility
DOI10.1016/j.pnpbp.2022.110657
通讯作者Wang, Mengya(wangmy@wnmc.edu.cn) ; Sui, Nan(suin@psych.ac.cn)
英文摘要Embryonic morphine exposure (EME) leads to abnormal brain development and behavior in the offspring, and the functional alteration of gamma-aminobutyric acid (GABA) system is considered to be one of the important mechanisms. To mimic the problem of susceptibility of human gestational drug abuse on addictive drugs in offspring, we administered morphine exposure on days 5-8 and 13-16 of chicken embryo development and examined the functions of GABA neurons and their receptors in postnatal chicks by neuroelectrophysiology, immunohistochemistry and behavioral methods. We found that morphine exposure during embryonic stages 5-8 (MorphineE5-8) significantly reduced the incidence of spontaneous inhibitory postsynaptic potentiation (IPSP) and the induction of evoked IPSP and the mean amplitude of GABAA agonist muscimol-induced response in the intermediate medial interstitial (IMM) region, compared to naive controls or saline-exposed chicks. The results of immunocytochemistry further suggest that MorphineE5-8 decreased the synaptic density of GAD-expressing sites in the IMM, while increased the expression of the GABAA receptor subtype gamma 2 isoform. Behavioral results found that Morphine5-8 treatment de-inhibited morphine-induced psychomotor responses in postnatal chicks. Morphine exposure at embryonic stages 13-16 (MorphineE13-16) showed no significant changes in the above indicators compared to the saline group. Evidence suggests that early embryonic morphine exposure leads to defects in GABAergic function in the IMM, which in turn alters the responsiveness of postnatal chicks to addictive drugs. These results will help to understand the GABA mechanisms by which embryonic addictive drug exposure contributes to offspring susceptibility to addiction.
收录类别SCI
WOS关键词GAMMA-AMINOBUTYRIC-ACID ; INTERMEDIATE MEDIAL MESOPALLIUM ; VENTRAL TEGMENTAL AREA ; PRENATAL EXPOSURE ; SEIZURE SUSCEPTIBILITY ; REWARDING PROPERTIES ; GABA(B) RECEPTORS ; OPIOID RECEPTORS ; PLACE PREFERENCE ; PRESYNAPTIC MU
资助项目National Natural Science Foundation[31300848] ; Key Laboratory of Mental Health, Institute of Psychology, CAS
WOS研究方向Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
语种英语
出版者PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号WOS:000882071600001
资助机构National Natural Science Foundation ; Key Laboratory of Mental Health, Institute of Psychology, CAS
源URL[http://ir.psych.ac.cn/handle/311026/43943]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Wang, Mengya; Sui, Nan
作者单位1.Chinese Acad Sci, Inst Psychol, 16 Lincui Rd, Beijing 100101, Peoples R China
2.Wannan Med Coll, Cell Electrophysiol Lab, Wuhu, Peoples R China
3.Univ Nebraska Lincoln, Dept Psychol, Lincoln, NE USA
4.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
5.Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Wang, Dongmei,Jiang, Juan,Shang, Wen,et al. Effect of early embryonic exposure to morphine on defects in the GABAergic system of day-old chicks[J]. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY,2023,121:9.
APA Wang, Dongmei.,Jiang, Juan.,Shang, Wen.,Zhang, Jianjun.,Jiang, Xiao.,...&Sui, Nan.(2023).Effect of early embryonic exposure to morphine on defects in the GABAergic system of day-old chicks.PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY,121,9.
MLA Wang, Dongmei,et al."Effect of early embryonic exposure to morphine on defects in the GABAergic system of day-old chicks".PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY 121(2023):9.

入库方式: OAI收割

来源:心理研究所

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