Structural network alterations and their association with neurological soft signs in schizophrenia: Evidence from clinical patients and unaffected siblings
文献类型：期刊论文
| 作者 | Kong, Li8,9; Lui, Simon S. Y.6,7; Wang, Ya5,9 ; Hung, Karen S. Y.6; Ho, Karen K. H.6; Wang, Yi5,9; Huang, Jia5,9; Mak, Henry K. F.3,4; Sham, Pak C.2,3,7; Cheung, Eric F. C.6
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| 刊名 | SCHIZOPHRENIA RESEARCH
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| 出版日期 | 2022-10-01 |
| 卷号 | 248页码:345-352 |
| 关键词 | Grey matter structural network Neurological soft signs Schizophrenia |
| ISSN号 | 0920-9964 |
| DOI | 10.1016/j.schres.2021.11.042 |
| 通讯作者 | Chan, Raymond C. K.(rckchan@psych.ac.cn) |
| 英文摘要 | Background: Grey matter abnormalities and neurological soft signs (NSS) have been found in schizophrenia patients and their unaffected relatives. Evidence suggested that NSS are associated with grey matter morphometrical alterations in multiple regions in schizophrenia. However, the association between NSS and structural abnormalities at network level remains largely unexplored, especially in the schizophrenia and unaffected siblings.Method: We used source-based morphometry (SBM) to examine the association of structural brain network characteristics with NSS in 62 schizophrenia patients, 25 unaffected siblings, and 60 healthy controls.Results: Two components, namely the IC-5 (superior temporal gyrus, inferior frontal gyrus and insula network) and the IC-10 (parahippocampal gyrus, fusiform, thalamus and insula network) showed significant grey matter reductions in schizophrenia patients compared to healthy controls and unaffected siblings. Further association analysis demonstrated separate NSS-related grey matter covarying patterns in schizophrenia, unaffected siblings and healthy controls. Specifically, NSS were negatively associated with IC-1 (hippocampus, caudate and thalamus network) and IC-5 in schizophrenia, but with IC-3 (caudate, superior and middle frontal cortices network) in unaffected siblings and with IC-5 in healthy controls.Conclusion: Our results confirmed the key cortical and subcortical network abnormalities and NSS-related grey matter covarying patterns in the schizophrenia and unaffected siblings. Our findings suggest that brain regions implicating genetic liability to schizophrenia are partly separated from brain regions implicating neural abnormalities. |
| 收录类别 | SCI |
| WOS关键词 | SOURCE-BASED MORPHOMETRY ; VOXEL-BASED MORPHOMETRY ; INDEPENDENT COMPONENTS ; LIKELIHOOD ESTIMATION ; MATTER ABNORMALITIES ; HIPPOCAMPAL VOLUME ; 1ST-EPISODE ; METAANALYSIS ; MORPHOLOGY ; ANOMALIES |
| 资助项目 | National Key Research and Development Program[2016YFC0906402] ; CAS Key Laboratory of Mental Health, Institute of Psychology ; Philip KH Wong Foundation |
| WOS研究方向 | Psychiatry |
| 语种 | 英语 |
| WOS记录号 | WOS:000880195300001 |
| 出版者 | ELSEVIER |
| 资助机构 | National Key Research and Development Program ; CAS Key Laboratory of Mental Health, Institute of Psychology ; Philip KH Wong Foundation |
| 源URL | [http://ir.psych.ac.cn/handle/311026/43995]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 通讯作者 | Chan, Raymond C. K. |
| 作者单位 | 1.Chinese Acad Sci, Inst Psychol, 16 Lincui Rd, Beijing 100101, Peoples R China 2.Univ Hong Kong, Ctr Panor Sci, Hong Kong, Peoples R China 3.Univ Hong Kong, State Key Lab Brain & Cognit Sci, Hong Kong, Peoples R China 4.Univ Hong Kong, Dept Diagnost Radiol, Hong Kong, Peoples R China 5.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 6.Castle Peak Hosp, Hong Kong, Peoples R China 7.Univ Hong Kong, Dept Psychiat, Hong Kong, Peoples R China 8.Shanghai Normal Univ, Dept Psychol, Shanghai, Peoples R China 9.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, CAS Key Lab Mental Hlth, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Kong, Li,Lui, Simon S. Y.,Wang, Ya,et al. Structural network alterations and their association with neurological soft signs in schizophrenia: Evidence from clinical patients and unaffected siblings[J]. SCHIZOPHRENIA RESEARCH,2022,248:345-352. |
| APA | Kong, Li.,Lui, Simon S. Y..,Wang, Ya.,Hung, Karen S. Y..,Ho, Karen K. H..,...&Chan, Raymond C. K..(2022).Structural network alterations and their association with neurological soft signs in schizophrenia: Evidence from clinical patients and unaffected siblings.SCHIZOPHRENIA RESEARCH,248,345-352. |
| MLA | Kong, Li,et al."Structural network alterations and their association with neurological soft signs in schizophrenia: Evidence from clinical patients and unaffected siblings".SCHIZOPHRENIA RESEARCH 248(2022):345-352. |
入库方式： OAI收割
来源：心理研究所
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