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The impact of childhood trauma on thalamic functional connectivity in patients with obsessive-compulsive disorder

文献类型：期刊论文

作者Chu, Minyi6; Xu, Tingting6; Wang, Yi4,5; Wang, Pei6; Gu, Qiumeng6; Liu, Qiang6; Cheung, Eric F. C.3; Chan, Raymond C. K.4,5,6; Wang, Zhen1,2,6
刊名PSYCHOLOGICAL MEDICINE
出版日期2022-10-01
卷号52期号:13页码:2471-2480
关键词Caudate childhood trauma cluster analysis obsessive-compulsive disorder resting-state functional connectivity thalamus
ISSN号0033-2917
DOI10.1017/S0033291720004328
通讯作者Chan, Raymond C. K.(rckchan@psych.ac.cn) ; Wang, Zhen(wangzhen@smhc.org.cn)
英文摘要Background Childhood trauma is a vulnerability factor for the development of obsessive-compulsive disorder (OCD). Empirical findings suggest that trauma-related alterations in brain networks, especially in thalamus-related regions, have been observed in OCD patients. However, the relationship between childhood trauma and thalamic connectivity in patients with OCD remains unclear. The present study aimed to examine the impact of childhood trauma on thalamic functional connectivity in OCD patients. Methods Magnetic resonance imaging resting-state scans were acquired in 79 patients with OCD, including 22 patients with a high level of childhood trauma (OCD_HCT), 57 patients with a low level of childhood trauma (OCD_LCT) and 47 healthy controls. Seven thalamic subdivisions were chosen as regions of interest (ROIs) to examine the group difference in thalamic ROIs and whole-brain resting-state functional connectivity (rsFC). Results We found significantly decreased caudate-thalamic rsFC in OCD patients as a whole group and also in OCD_LCT patients, compared with healthy controls. However, OCD_HCT patients exhibited increased thalamic rsFC with the prefrontal cortex when compared with both OCD_LCT patients and healthy controls. Conclusions Taken together, OCD patients with high and low levels of childhood trauma exhibit different pathological alterations in thalamic rsFC, suggesting that childhood trauma may be a predisposing factor for some OCD patients.
收录类别SCI
WOS关键词EARLY-LIFE STRESS ; RESPONSE-INHIBITION ; NETWORK ; ABNORMALITIES ; METAANALYSIS ; DEPRESSION ; CORTEX ; RISK ; DISSOCIATION ; MALTREATMENT
资助项目National Natural Science Foundation of China[81671340] ; National Key Research and Development Programme[2016YFC0906402] ; Shanghai Municipal Education Commission-Gao Feng Clinical Medicine[20161321] ; Shanghai Municipal Health Commission[2017BR058] ; Shanghai Municipal Health Commission[2019ZB0201] ; Shanghai Key Laboratory of Psychotic Disorders[13dz2260500] ; CAS Key Laboratory of Mental Health, Institute of Psychology
WOS研究方向Psychology ; Psychiatry
语种英语
WOS记录号WOS:000880310400010
出版者CAMBRIDGE UNIV PRESS
资助机构National Natural Science Foundation of China ; National Key Research and Development Programme ; Shanghai Municipal Education Commission-Gao Feng Clinical Medicine ; Shanghai Municipal Health Commission ; Shanghai Key Laboratory of Psychotic Disorders ; CAS Key Laboratory of Mental Health, Institute of Psychology
源URL[http://ir.psych.ac.cn/handle/311026/43998]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Chan, Raymond C. K.; Wang, Zhen
作者单位1.Shanghai Key Lab Psychot Disorders, Shanghai, Peoples R China
2.Shanghai Jiao Tong Univ, Inst Psychol & Behav Sci, Shanghai, Peoples R China
3.Castle Peak Hosp, Hong Kong, Peoples R China
4.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
5.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci, Beijing, Peoples R China
6.Shanghai Jiao Tong Univ, Shanghai Mental Hlth Ctr, Sch Med, Shanghai, Peoples R China
推荐引用方式
GB/T 7714		 Chu, Minyi,Xu, Tingting,Wang, Yi,et al. The impact of childhood trauma on thalamic functional connectivity in patients with obsessive-compulsive disorder[J]. PSYCHOLOGICAL MEDICINE,2022,52(13):2471-2480.
APA Chu, Minyi.,Xu, Tingting.,Wang, Yi.,Wang, Pei.,Gu, Qiumeng.,...&Wang, Zhen.(2022).The impact of childhood trauma on thalamic functional connectivity in patients with obsessive-compulsive disorder.PSYCHOLOGICAL MEDICINE,52(13),2471-2480.
MLA Chu, Minyi,et al."The impact of childhood trauma on thalamic functional connectivity in patients with obsessive-compulsive disorder".PSYCHOLOGICAL MEDICINE 52.13(2022):2471-2480.

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来源：心理研究所

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