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The association of glutamate level in pregenual anterior cingulate, anhedonia, and emotion-behavior decoupling in patients with major depressive disorder

文献类型：期刊论文

作者Wang, Kui-Lai8; Liang, Kun3; Wang, Li-Jun8; Shen, Jian-Fei8; Zhu, Guo-Hui6; Zhang, Shu-Xian7; Wang, Xi-Zhen7; Wang, Yi2,4,5; Wang, Yan-Yu1,8
刊名ASIAN JOURNAL OF PSYCHIATRY
出版日期2022-12-01
卷号78页码:4
关键词Major depressive disorder Emotion -behavior decoupling Anhedonia Magnetic resonance spectroscopy Glutamate
ISSN号1876-2018
DOI10.1016/j.ajp.2022.103306
通讯作者Wang, Yi(wangyi@psych.ac.cn) ; Wang, Yan-Yu(wangyanyu@wfmc.edu.cn)
英文摘要Impairments of translating emotional salience into effortful behavior are core features of anhedonia in cohorts with major depressive disorder. Glutamate metabolism is considered to be involved in this process, but the empirical study is relatively few. Therefore, the present study aimed to examine the correlations between glutamate level in pregenual anterior cingulate, anhedonia, and emotion-behavior decoupling in patients with major depressive disorder. Fifteen individuals diagnosed with major depressive disorder and ten healthy individuals were recruited. All participants were asked to complete self-report instruments for anhedonia and the computerized anticipatory and consummatory pleasure task, and the in vivo glutamate levels were measured by proton magnetic resonance spectroscopy. Thus, a potential lower glutamate levels in pregenual anterior cingulate in individuals with major depressive disorder were founded to be positively correlated with the ability of pleasure experiencing. The mechanism of glutamate in pregenual anterior cingulate in anhedonia in patients with major depressive disorder may be reflected in the early pleasurable experience stage, rather than in the transformation of emotional experience to motivation or reward-seeking behavior, which may be different from that in schizophrenia.
收录类别SCI
WOS关键词AFFECTIVE EXPERIENCE ; SCHIZOPHRENIA
资助项目Humanities and Social Science Research Project, Ministry of Education, China[19YJA190006] ; Natural Science Foundation of Shandong Province[ZR2021MC103] ; National Natural Science Foundation of China[31871114]
WOS研究方向Psychiatry
语种英语
WOS记录号WOS:000880128100002
出版者ELSEVIER
资助机构Humanities and Social Science Research Project, Ministry of Education, China ; Natural Science Foundation of Shandong Province ; National Natural Science Foundation of China
源URL[http://ir.psych.ac.cn/handle/311026/44004]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Wang, Yi; Wang, Yan-Yu
作者单位1.Weifang Med Univ, Sch Psychol, 7166 Baotongxi St, Weifang 261053, Shandong, Peoples R China
2.Chinese Acad Sci, Inst Psychol, 16 Lincui Rd, Beijing 100101, Peoples R China
3.Capital Med Univ, Beijing Neurosurg Inst, Dept Funct Neurosurg, Beijing, Peoples R China
4.Univ Chinese Acad Sci, Dept Psychol, Beijing 100048, Peoples R China
5.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, Key Lab Mental Hlth, Beijing 100101, Peoples R China
6.Mental Hlth Ctr Weifang City, Weifang 261071, Shandong, Peoples R China
7.Weifang Med Univ, Magnet Resonance Imaging Ctr, Affiliated Hosp, Weifang 261031, Shandong, Peoples R China
8.Weifang Med Univ, Sch Psychol, Weifang 261053, Shandong, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Kui-Lai,Liang, Kun,Wang, Li-Jun,et al. The association of glutamate level in pregenual anterior cingulate, anhedonia, and emotion-behavior decoupling in patients with major depressive disorder[J]. ASIAN JOURNAL OF PSYCHIATRY,2022,78:4.
APA Wang, Kui-Lai.,Liang, Kun.,Wang, Li-Jun.,Shen, Jian-Fei.,Zhu, Guo-Hui.,...&Wang, Yan-Yu.(2022).The association of glutamate level in pregenual anterior cingulate, anhedonia, and emotion-behavior decoupling in patients with major depressive disorder.ASIAN JOURNAL OF PSYCHIATRY,78,4.
MLA Wang, Kui-Lai,et al."The association of glutamate level in pregenual anterior cingulate, anhedonia, and emotion-behavior decoupling in patients with major depressive disorder".ASIAN JOURNAL OF PSYCHIATRY 78(2022):4.

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来源：心理研究所

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