中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 心理研究所
  3. 中国科学院心理研究所
  4. 中国科学院心理健康重点实验室
Association of Transferrin Gene Polymorphism with Cognitive Deficits and Psychiatric Symptoms in Patients with Chronic Schizophrenia

文献类型：期刊论文

作者Chen, Pinhong5; Wang, Dongmei3,4; Xiu, Meihong2; Chen, Dachun2; Lackey, Blake1; Wu, Hanjing E.1; Wang, Lubin5; Zhang, Xiangyang3,4
刊名JOURNAL OF CLINICAL MEDICINE
出版日期2022-11-01
卷号11期号:21页码:12
关键词transferrin genetic polymorphism psychiatric symptoms cognitive deficits schizophrenia
DOI10.3390/jcm11216414
通讯作者Zhang, Xiangyang(zhangxy@psych.ac.cn)
英文摘要A large amount of recent literature has focused on impaired iron homeostasis in the pathophysiology of schizophrenia. Specifically, microarray analysis has illustrated associations between the transferrin locus and schizophrenia. To elaborate on the effects of transferrin on schizophrenia and its psychiatric phenotypes, our study aimed to investigate whether transferrin gene polymorphism was correlated with cognitive deficits and clinical symptoms in schizophrenia. We recruited 564 patients with chronic schizophrenia and 422 healthy controls (HCs) in a Han Chinese population, collected phenotypic data, and genotyped the rs3811655 polymorphism of the transferrin gene. Our results showed that the rs3811655 polymorphism was related to cognitive performance in both patients and HCs, as well as negative symptoms in patients (all p < 0.05), and patients carrying at least one G-allele showed worsened cognition/severe negative symptoms (all p < 0.05). Further analyses also found that the rs3811655 polymorphism in combination with cognition may exert small but significant contributions to the negative (beta = -0.10, t = -2.48, p < 0.05) or total psychiatric symptoms (beta = -0.08, t = -1.92, p < 0.05) in patients. Our findings indicated that the rs3811655 polymorphism may be implicated in the cognitive deficits of schizophrenia and HCs as well as psychiatric symptoms in patients, which suggested the possible iron regulatory mechanism in the pathology of schizophrenia.
收录类别SCI
WOS关键词IRON-DEFICIENCY ; SERUM IRON ; EXPRESSION ; BEHAVIOR ; MARKERS
资助项目National Natural Science Foundation of China[61673391] ; Psychosis project of the Beijing Key Laboratory[Z161100002616017] ; CAS International Cooperation Research Program[153111KYSB20190004]
WOS研究方向General & Internal Medicine
语种英语
出版者MDPI
WOS记录号WOS:000881170500001
资助机构National Natural Science Foundation of China ; Psychosis project of the Beijing Key Laboratory ; CAS International Cooperation Research Program
源URL[http://ir.psych.ac.cn/handle/311026/44007]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Zhang, Xiangyang
作者单位1.Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, Houston, TX 77030 USA
2.Peking Univ, Beijing Huilongguan Hosp, Beijing 100871, Peoples R China
3.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China
4.Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, Beijing 100101, Peoples R China
5.Beijing Inst Basic Med Sci, Beijing 100850, Peoples R China
推荐引用方式
GB/T 7714		 Chen, Pinhong,Wang, Dongmei,Xiu, Meihong,et al. Association of Transferrin Gene Polymorphism with Cognitive Deficits and Psychiatric Symptoms in Patients with Chronic Schizophrenia[J]. JOURNAL OF CLINICAL MEDICINE,2022,11(21):12.
APA Chen, Pinhong.,Wang, Dongmei.,Xiu, Meihong.,Chen, Dachun.,Lackey, Blake.,...&Zhang, Xiangyang.(2022).Association of Transferrin Gene Polymorphism with Cognitive Deficits and Psychiatric Symptoms in Patients with Chronic Schizophrenia.JOURNAL OF CLINICAL MEDICINE,11(21),12.
MLA Chen, Pinhong,et al."Association of Transferrin Gene Polymorphism with Cognitive Deficits and Psychiatric Symptoms in Patients with Chronic Schizophrenia".JOURNAL OF CLINICAL MEDICINE 11.21(2022):12.

入库方式： OAI收割

来源：心理研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。