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A comparison of methods to harmonize cortical thickness measurements across scanners and sites

文献类型：期刊论文

作者Sun, Delin16,80,81; Rakesh, Gopalkumar80,81; Haswell, Courtney C.80,81; Logue, Mark76,77,78,79; Baird, C. Lexi80,81; O'Leary, Erin N.75; Cotton, Andrew S.75; Xie, Hong75; Tamburrino, Marijo75; Chen, Tian74,75
刊名NEUROIMAGE
出版日期2022-11-01
卷号261页码:19
关键词Data Harmonization Scanner Effects Site Effects Cortical Thickness ComBat ComBat-GAM Linear Mixed-Effects Model General Additive Model PTSD
ISSN号1053-8119
DOI10.1016/j.neuroimage.2022.119509
通讯作者Morey, Rajendra A.(rajendra.morey@duke.edu)
英文摘要Results of neuroimaging datasets aggregated from multiple sites may be biased by site-specific profiles in participants' demographic and clinical characteristics, as well as MRI acquisition protocols and scanning platforms. We compared the impact of four different harmonization methods on results obtained from analyses of cortical thickness data: (1) linear mixed-effects model (LME) that models site-specific random intercepts (LME INT), (2) LME that models both site-specific random intercepts and age-related random slopes (LME INT+ SLP), (3) ComBat, and (4) ComBat with a generalized additive model (ComBat-GAM). Our test case for comparing harmonization methods was cortical thickness data aggregated from 29 sites, which included 1,340 cases with posttraumatic stress disorder (PTSD) (6.2-81.8 years old) and 2,057 trauma-exposed controls without PTSD (6.3-85.2 years old). We found that, compared to the other data harmonization methods, data processed with ComBat-GAM was more sensitive to the detection of significant case-control differences (X-2 (3) = 63.704, p < 0.001) as well as casecontrol differences in age-related cortical thinning (X-2 (3) = 12.082, p = 0.007). Both ComBat and ComBat-GAM outperformed LME methods in detecting sex differences (X-2 (3) = 9.114, p = 0.028) in regional cortical thickness. ComBat-GAM also led to stronger estimates of age-related declines in cortical thickness (corrected p-values < 0.001), stronger estimates of case-related cortical thickness reduction (corrected p-values < 0.001), weaker estimates of age-related declines in cortical thickness in cases than controls (corrected p-values < 0.001), stronger estimates of cortical thickness reduction in females than males (corrected p-values < 0.001), and stronger estimates of cortical thickness reduction in females relative to males in cases than controls (corrected p-values < 0.001). Our results support the use of ComBat-GAM to minimize confounds and increase statistical power when harmonizing data with non-linear effects, and the use of either ComBat or ComBat-GAM for harmonizing data with linear effects.
收录类别SCI
WOS关键词MULTISITE ; DISORDER ; VOLUME
资助项目DoD[W81XWH-10-1-0925] ; Center for Brain and Behavior Research Pilot Grant ; South Dakota Governor's Research Center Grant ; VA CDA[CX001600] ; NHMRC[1073041] ; NHMRC[R01 MH111671] ; VISN6 MIRECC ; German Research Foundation[DA 1222/4-1] ; German Research Foundation[WA 1539/8-2] ; VA RRD[1IK2RX000709] ; VA RRD[1K1RX002325] ; VA RRD[1K2RX002922] ; VA RRD[MH101380] ; VA RRD[I01RX000622] ; NIMH[R01-MH043454] ; NIMH[K01-MH122774] ; NIMH[K01 MH118428-01] ; NIMH[R01MH105535] ; NIMH[1R21MH102634] ; ZonMw, the Netherlands organization for Health Research and Development[40-0081298-10041] ; Academic Medical Center Research Council[110614] ; VA CSRD[1IK2CX001680] ; VISN17 Center of Excellence pilot funding ; German Federal Ministry of Education and Research[BMBF RELEASE 01KR1303A] ; German Research Society (Deutsche Forschungsgemeinschaft, DFG)[SFB/TRR 58] ; Anonymous Women's Health Fund ; Kasparian Fund ; Trauma Scholars Fund ; Barlow Family Fund ; Department of Veterans Affairs ; NIAAA ; NCATS ; NIH[R01 MH106574] ; NIH[F32MH109274] ; BOF 2-4 year project[01J05415] ; Dana Foundation ; University of Wisconsin Institute for Clinical and Translational Research ; National Science Foundation Graduate Research Fellowship ; National Institute of Child Health and Human Development[P30-HD003352] ; Veterans Affairs Merit Review Program[10/01/08 09/30/13] ; South African Medical Research Council SHARED ROOTS Flagship Project ; South African Research Chair in PTSD from the Department of Science and Technology ; National Research Foundation ; US Department of Defense[W81XWH08-2-0159] ; CDMRP[W81XWH-08-2-0038] ; South African Medical Research Council ; NARSAD ; Department of Defense[W81XWH-12-2-0012] ; Big Data to Knowledge (BD2K) program[U54 EB020403] ; 'NIMH'[R01-MH043454] ; 'NIMH'[1R21MH102634] ; 'NIMH'[R01 MH63407] ; 'NIMH'[K01 MH118467] ; 'NIMH'[W81XWH-08-2-0159] ; 'NIMH'[K23MH112873] ; 'NIMH'[R01MH113574] ; 'NIMH'[R01-MH103291] ; 'NIMH'[R01 AA12479] ; 'NIMH'[R01 MH61744] ; 'NIMH'[T32-MH018931] ; [5U01AA021681-08] ; [K24MH71434] ; [K24 DA028773] ; [K99NS096116] ; [R01MH117601] ; [R01AG059874] ; [MJFF 14848] ; [MH098212] ; [MH071537] ; [M01RR00039] ; [UL1TR000454] ; [HD071982] ; [HD085850] ; [R21MH112956] ; [R01MH105355] ; [L30 MH114379] ; [RFA-FSP-01-2013/SHARED ROOTS] ; [R56AG058854] ; [R01MH116147] ; [P41 EB015922] ; [1R01MH110483] ; [1R21 MH098198] ; [R01MH105355-01A]
WOS研究方向Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
语种英语
WOS记录号WOS:000889462400003
出版者ACADEMIC PRESS INC ELSEVIER SCIENCE
资助机构DoD ; Center for Brain and Behavior Research Pilot Grant ; South Dakota Governor's Research Center Grant ; VA CDA ; NHMRC ; VISN6 MIRECC ; German Research Foundation ; VA RRD ; NIMH ; ZonMw, the Netherlands organization for Health Research and Development ; Academic Medical Center Research Council ; VA CSRD ; VISN17 Center of Excellence pilot funding ; German Federal Ministry of Education and Research ; German Research Society (Deutsche Forschungsgemeinschaft, DFG) ; Anonymous Women's Health Fund ; Kasparian Fund ; Trauma Scholars Fund ; Barlow Family Fund ; Department of Veterans Affairs ; NIAAA ; NCATS ; NIH ; BOF 2-4 year project ; Dana Foundation ; University of Wisconsin Institute for Clinical and Translational Research ; National Science Foundation Graduate Research Fellowship ; National Institute of Child Health and Human Development ; Veterans Affairs Merit Review Program ; South African Medical Research Council SHARED ROOTS Flagship Project ; South African Research Chair in PTSD from the Department of Science and Technology ; National Research Foundation ; US Department of Defense ; CDMRP ; South African Medical Research Council ; NARSAD ; Department of Defense ; Big Data to Knowledge (BD2K) program ; 'NIMH'
源URL[http://ir.psych.ac.cn/handle/311026/44075]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Morey, Rajendra A.
作者单位1.Neurosci Res Australia, Randwick, NSW, Australia
2.Univ Rochester, Med Ctr, Del Monte Inst Neurosci, Rochester, NY 14642 USA
3.Washington Univ, Dept Radiol, St Louis, MO 63110 USA
4.Univ Toledo, Dept Math & Stat, Toledo, OH USA
5.Univ Calif Irvine, Ctr Neurobiol Learning & Memory, Irvine, CA USA
6.Univ Calif Irvine, Dept Psychiat & Human Behav, Clin Translat Neurosci Lab, Irvine, CA 92717 USA
7.Texas A&M Univ, Dept Psychiat & Behav Sci, College Stn, TX USA
8.VA Palo Alto Hlth Care Syst, Palo Alto, CA USA
9.Penn State Univ, Dept Psychiat & Behav Hlth, Hershey, PA USA
10.Texas A&M Univ, Hlth Sci Ctr, Dept Psychiat & Behav Sci, Bryan, TX USA
推荐引用方式
GB/T 7714		 Sun, Delin,Rakesh, Gopalkumar,Haswell, Courtney C.,et al. A comparison of methods to harmonize cortical thickness measurements across scanners and sites[J]. NEUROIMAGE,2022,261:19.
APA Sun, Delin.,Rakesh, Gopalkumar.,Haswell, Courtney C..,Logue, Mark.,Baird, C. Lexi.,...&Morey, Rajendra A..(2022).A comparison of methods to harmonize cortical thickness measurements across scanners and sites.NEUROIMAGE,261,19.
MLA Sun, Delin,et al."A comparison of methods to harmonize cortical thickness measurements across scanners and sites".NEUROIMAGE 261(2022):19.

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来源：心理研究所

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