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Diminished treatment response in relapsed versus first-episode schizophrenia as revealed by a panel of blood-based biomarkers: A combined cross-sectional and longitudinal study

文献类型：期刊论文

作者Cai, Hualin7,8,9; Zeng, Cuirong8,9; Zhang, Xiangyang5,6; Liu, Yong3,4; Wu, Renrong3,4; Guo, Wenbin3,4; Wang, Jianjian3,4; Wu, Haishan3,4; Tang, Hui3,4; Ge, Xiaoping2
刊名PSYCHIATRY RESEARCH
出版日期2022-10-01
卷号316页码:12
关键词Atypical antipsychotic drug First-episode schizophrenia Relapse Biomarker Treatment response
ISSN号0165-1781
DOI10.1016/j.psychres.2022.114762
通讯作者Cai, Hualin(hualincai@csu.edu.cn) ; Yang, Ping(cuteping12384@126.com) ; Zhang, Bikui(505995@csu.edu.cn)
英文摘要There is a paucity of biomarkers for the prediction of treatment response in schizophrenia. In this study, we aimed to investigate whether diminished antipsychotic treatment response in relapsed versus first-episode schizophrenia can be revealed and predicted by a panel of blood-based biomarkers. A cross-sectional cohort consisting of 655 schizophrenia patients at different episodes and 606 healthy controls, and a longitudinal cohort including 52 first-episode antipsychotic-naive schizophrenia patients treated with the same antipsychotic drugs during the 5-year follow-up of their first three episodes were enrolled. Plasma biomarker changes and symptom improvement were compared between the drug-free phase of psychosis onset and after 4 weeks of atypical antipsychotic drug (AAPD) treatment. In response to treatment, the extent of changes in the biomarkers of bioenergetic, purinergic, phospholipid and neurosteroid metabolisms dwindled down as number of episode and illness duration increased in relapsed schizophrenia. The changes of creatine, inosine, progesterone, allopreg-nanolone, cortisol and PE(16:0/22:6) were significantly correlated with the improvement of symptomatology. Inosine and progesterone at baseline were shown to be strong predictive biomarkers of treatment response. The results suggest that AAPD treatment response is diminished in the context of relapse, and our findings open new avenues for understanding the pathophysiology of treatment-resistance schizophrenia.
收录类别SCI
WOS关键词ANGIOTENSIN-CONVERTING ENZYME ; ATYPICAL ANTIPSYCHOTICS ; ORAL SUPPLEMENTATION ; THERAPEUTIC TARGET ; CREATINE-KINASE ; UP-REGULATION ; 1ST EPISODE ; HUMAN BRAIN ; S100B ; ABNORMALITIES
资助项目Hunan Provincial Natural Science Foundation of China[2021JJ30922] ; Hunan Provincial Health Commission Research Project[202113010595] ; Hunan Provincial Depression Disorder Clinical Medical Research Center[2021SK4022] ; Hunan Provincial Science and Technology Major Special Project[2018SK1030] ; Wu Jieping Medical Foundation Funded Special Clinical Research Project[320.6750.2020-04-2] ; Changsha Municipal Natural Science Foundation[kq2007045] ; Talent Project by Chinese Pharmaceutical Association Hospital Pharmacy Department[CPA-Z05-ZC-2021-003] ; Fundamental Research Funds for the Central Universities of Central South University[2021zzts1073] ; New Clinical Medical Technology Project of the Second Xiangya Hos-pital of Central South University[[2021] 94]
WOS研究方向Psychiatry
语种英语
WOS记录号WOS:000891312400008
出版者ELSEVIER IRELAND LTD
资助机构Hunan Provincial Natural Science Foundation of China ; Hunan Provincial Health Commission Research Project ; Hunan Provincial Depression Disorder Clinical Medical Research Center ; Hunan Provincial Science and Technology Major Special Project ; Wu Jieping Medical Foundation Funded Special Clinical Research Project ; Changsha Municipal Natural Science Foundation ; Talent Project by Chinese Pharmaceutical Association Hospital Pharmacy Department ; Fundamental Research Funds for the Central Universities of Central South University ; New Clinical Medical Technology Project of the Second Xiangya Hos-pital of Central South University
源URL[http://ir.psych.ac.cn/handle/311026/44093]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Cai, Hualin; Yang, Ping; Zhang, Bikui
作者单位1.Hunan Brain Hosp, Dept Psychiat, 427 Furong Rd, Changsha 410000, Hunan, Peoples R China
2.Changsha Psychiat Hosp, Dept Psychiat, Changsha, Peoples R China
3.Natl Clin Res Ctr Mental Disorders, Changsha, Peoples R China
4.Cent South Univ, Dept Psychiat, Xiangya Hosp 2, Changsha, Peoples R China
5.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
6.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
7.Int Res Ctr Precis Med Transformat Technol & Softw, Changsha, Hunan, Peoples R China
8.Cent South Univ, Inst Clin Pharm, Changsha, Peoples R China
9.Cent South Univ, Xiangya Hosp 2, Inst Clin Pharm, Dept Pharm, 139 Renmin Rd, Changsha 410011, Hunan, Peoples R China
推荐引用方式
GB/T 7714		 Cai, Hualin,Zeng, Cuirong,Zhang, Xiangyang,et al. Diminished treatment response in relapsed versus first-episode schizophrenia as revealed by a panel of blood-based biomarkers: A combined cross-sectional and longitudinal study[J]. PSYCHIATRY RESEARCH,2022,316:12.
APA Cai, Hualin.,Zeng, Cuirong.,Zhang, Xiangyang.,Liu, Yong.,Wu, Renrong.,...&Zhang, Bikui.(2022).Diminished treatment response in relapsed versus first-episode schizophrenia as revealed by a panel of blood-based biomarkers: A combined cross-sectional and longitudinal study.PSYCHIATRY RESEARCH,316,12.
MLA Cai, Hualin,et al."Diminished treatment response in relapsed versus first-episode schizophrenia as revealed by a panel of blood-based biomarkers: A combined cross-sectional and longitudinal study".PSYCHIATRY RESEARCH 316(2022):12.

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来源：心理研究所

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