中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 心理研究所
  3. 中国科学院心理研究所
  4. 中国科学院行为科学重点实验室
Disrupted effective connectivity of the default, salience and dorsal attention networks in major depressive disorder: a study using spectral dynamic causal modelling of resting-state fMRI

文献类型：期刊论文

作者Wang, Yun5,6; Chen, Xiongying5,6; Liu, Rui5,6; Zhang, Zhifang5,6; Zhou, Jingjing5,6; Feng, Yuan4,5,6; Zeidman, Peter3; Wang, Gang4,5,6,7,8; Zhou, Yuan1,2,5,6,9
刊名JOURNAL OF PSYCHIATRY & NEUROSCIENCE
出版日期2022-12-06
卷号47期号:6页码:E421-E434
ISSN号1180-4882
DOI10.1503/jpn.220038
通讯作者Wang, Gang(gangwangdoc@ccmu.edu.cn) ; Zhou, Yuan(zhouyuan@psych.ac.cn)
英文摘要Background:Understanding the neural basis for major depressive disorder (MDD) is essential for its diagnosis and treatment. Aberrant activation and functional connectivity of the default mode network (DMN), salience network (SN) and dorsal attention network (DAN) have been found consistently in patients with MDD. However, whether effective connectivity within and between these networks is altered in MDD remains unknown. The primary objective of this study was to investigate the effective connectivity of the 3 networks in patients with MDD at rest. Methods:We included 63 patients with MDD (35 first-episode and 28 recurrent) and 74 healthy controls, and collected resting-state functional MRI data for all participants. We defined 15 regions of interest from the 3 functional brain networks of interest using group independent component analysis. We estimated the coupling parameters that reflected the causal interactions among these regions using spectral dynamic causal modelling. We used parametric empirical Bayes to determine commonalities across groups, differences between patients with MDD and healthy controls, and differences between patients with recurrent and first-episode MDD. Results:We found positive (excitatory) connections within each network, negative (inhibitory) connections from the SN and DAN to the DMN, and positive connections from the DAN to the SN across groups. Compared to healthy controls, patients with MDD showed increased positive connections within the DMN, a decreased absolute value of negative connectivity from the SN to the DMN, and increased positive connections from the SN to the DAN. We also found that patients with recurrent MDD showed remarkably different effective connections compared to patients with first-episode MDD, especially related to the DAN. Limitations:Because of the relatively small sample size and the unclear medication history of the MDD sample, the present findings are in need of replication. Conclusion:These findings suggest that effective connectivity among high-order brain functional networks during rest was disrupted in patients with MDD. Moreover, patients with recurrent MDD exhibited different effective connections compared to patients with first-episode MDD. These differences in effective connectivity might provide new insights into the neural substrates of MDD.
收录类别SCI
WOS关键词FUNCTIONAL CONNECTIVITY ; HUMAN BRAIN ; METAANALYSIS ; 1ST-EPISODE ; DYSFUNCTION ; MATTER ; CORTEX ; ONSET ; TIME
WOS研究方向Neurosciences & Neurology ; Psychiatry
语种英语
出版者CMA-CANADIAN MEDICAL ASSOC
WOS记录号WOS:000896740300001
源URL[http://ir.psych.ac.cn/handle/311026/44072]  
专题心理研究所_中国科学院行为科学重点实验室
通讯作者Wang, Gang; Zhou, Yuan
作者单位1.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
2.Inst Psychol, CAS Key Lab Behav Sci, Beijing, Peoples R China
3.Wellcome Ctr Human Neuroimaging, London, England
4.Capital Med Univ, Adv Innovat Ctr Human Brain Protect, Beijing, Peoples R China
5.Beijing Anding Hosp, Beijing Key Lab Mental Disorders, Beijing, Peoples R China
6.Beijing Anding Hosp, Natl Clin Res Ctr Mental Disorders, Beijing, Peoples R China
7.Beijing Anding Hosp, Beijing Key Lab Mental Disorders, Beijing 100088, Peoples R China
8.Beijing Anding Hosp, Natl Clin Res Ctr Mental Disorders, Beijing 100088, Peoples R China
9.Inst Psychol, CAS Key Lab Behav Sci, Beijing 100101, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Yun,Chen, Xiongying,Liu, Rui,et al. Disrupted effective connectivity of the default, salience and dorsal attention networks in major depressive disorder: a study using spectral dynamic causal modelling of resting-state fMRI[J]. JOURNAL OF PSYCHIATRY & NEUROSCIENCE,2022,47(6):E421-E434.
APA Wang, Yun.,Chen, Xiongying.,Liu, Rui.,Zhang, Zhifang.,Zhou, Jingjing.,...&Zhou, Yuan.(2022).Disrupted effective connectivity of the default, salience and dorsal attention networks in major depressive disorder: a study using spectral dynamic causal modelling of resting-state fMRI.JOURNAL OF PSYCHIATRY & NEUROSCIENCE,47(6),E421-E434.
MLA Wang, Yun,et al."Disrupted effective connectivity of the default, salience and dorsal attention networks in major depressive disorder: a study using spectral dynamic causal modelling of resting-state fMRI".JOURNAL OF PSYCHIATRY & NEUROSCIENCE 47.6(2022):E421-E434.

入库方式： OAI收割

来源：心理研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。