On-line measurement of propofol using membrane inlet ion mobility spectrometer
文献类型：期刊论文
| 作者 | Zhou, Qinghua1,2; Wang, Weiguo1; Cang, Huaiwen1; Du, Yongzhai1,2; Han, Fenglei1,2; Chen, Chuang1,2; Cheng, Shasha1,2; Li, Jinghua1; Li, Haiyang1 |
| 刊名 | talanta
 |
| 出版日期 | 2012-08-30 |
| 卷号 | 98页码:241-246 |
| 关键词 | Membrane inlet Ion mobility spectrometer Propofol Exhaled air |
| ISSN号 | 0039-9140 |
| 产权排序 | 1,1 |
| 通讯作者 | 李海洋 |
| 英文摘要 | the concentration of propofol in patient's exhaled air is an indicator of the anesthetic depth. in the present study, a membrane inlet ion mobility spectrometer (mi-ims) was built for the on-line measurement of propofol. compared with the direct sample introduction, the membrane inlet could eliminate the interference of moisture and improve the selectivity of propofol. effects of membrane temperature and carrier gas flow rate on the sensitivity and response time have been investigated experimentally and theoretically. under the optimized experimental conditions of membrane temperature 100 degrees c and carrier gas flow rate 200 ml min(-1), the calculated limit of detection (lod) for propofol was 1 ppbv, and the calibration curve was linear in the range of 10-83 ppbv with a correlation coefficient (r-2) of 0.993. finally, the propofol concentration in an anaesthetized mouse exhaled air was monitored continuously to demonstrate the capability of mi-ims in the on-line measurement of propofol in real samples. (c) 2012 elsevier b.v. all rights reserved. |
| 学科主题 | 物理化学 |
| 类目[WOS] | chemistry, analytical |
| 研究领域[WOS] | chemistry |
| 关键词[WOS] | degradation-products ; gas ; water ; feasibility ; metabolites ; explosives ; arterial ; surgery ; plasma ; air |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000309327600035 |
| 公开日期 | 2013-10-11 |
| 源URL | [http://159.226.238.44/handle/321008/118156]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Liaoning, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Qinghua,Wang, Weiguo,Cang, Huaiwen,et al. On-line measurement of propofol using membrane inlet ion mobility spectrometer[J]. talanta,2012,98:241-246. |
| APA | Zhou, Qinghua.,Wang, Weiguo.,Cang, Huaiwen.,Du, Yongzhai.,Han, Fenglei.,...&Li, Haiyang.(2012).On-line measurement of propofol using membrane inlet ion mobility spectrometer.talanta,98,241-246. |
| MLA | Zhou, Qinghua,et al."On-line measurement of propofol using membrane inlet ion mobility spectrometer".talanta 98(2012):241-246. |
入库方式： OAI收割
来源：大连化学物理研究所
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