Potent and selective inhibition of magnolol on catalytic activities of UGT1A7 and 1A9
文献类型：期刊论文
| 作者 | Zhu, Liangliang1,2; Ge, Guangbo1; Liu, Yong1; He, Guiyuan1,2; Liang, Sicheng1; Fang, Zhongze1,2; Dong, Peipei3; Cao, Yunfeng1; Yang, Ling1 |
| 刊名 | xenobiotica
 |
| 出版日期 | 2012-10-01 |
| 卷号 | 42期号:10页码:1001-1008 |
| 关键词 | Magnolol UDP-glucuronosyltransferases glucuronidation UGT inhibitor |
| 产权排序 | 1,1 |
| 通讯作者 | 杨凌 |
| 英文摘要 | 1. human exposure to magnolol can reach a high dose in daily life. our previous studies indicated that magnolol showed high affinities to several udp-glucuronosyltransferases (ugts) this study was designed to examine the in vitro inhibitory effects of magnolol on ugts, and further to evaluate the possibility of the in vivo inhibition that might happen. |
| 学科主题 | 物理化学 |
| 类目[WOS] | pharmacology & pharmacy ; toxicology |
| 研究领域[WOS] | pharmacology & pharmacy ; toxicology |
| 关键词[WOS] | human udp-glucuronosyltransferases ; human liver-microsomes ; in-vitro ; glucuronidation ; kinetics ; androsterone ; specificity ; enzymes ; single ; ugt2b7 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000308411600006 |
| 公开日期 | 2013-10-11 |
| 源URL | [http://159.226.238.44/handle/321008/118185]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing, Peoples R China 3.Dalian Med Univ, Res Inst Integrated Tradit & Western Med, Dalian, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhu, Liangliang,Ge, Guangbo,Liu, Yong,et al. Potent and selective inhibition of magnolol on catalytic activities of UGT1A7 and 1A9[J]. xenobiotica,2012,42(10):1001-1008. |
| APA | Zhu, Liangliang.,Ge, Guangbo.,Liu, Yong.,He, Guiyuan.,Liang, Sicheng.,...&Yang, Ling.(2012).Potent and selective inhibition of magnolol on catalytic activities of UGT1A7 and 1A9.xenobiotica,42(10),1001-1008. |
| MLA | Zhu, Liangliang,et al."Potent and selective inhibition of magnolol on catalytic activities of UGT1A7 and 1A9".xenobiotica 42.10(2012):1001-1008. |
入库方式： OAI收割
来源：大连化学物理研究所
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