Taxol-induced alteration of intracellular amino-acid profile related to human cervical carcinoma HeLa cell death
文献类型：期刊论文
| 作者 | Han, Xiao-Fei; Liu, Yan-Qiu; Wang, Long-Xing; Yang, Qian-Xu; Xiao, Hong-Bin |
| 刊名 | biotechnology letters
 |
| 出版日期 | 2012 |
| 卷号 | 34期号:1页码:1-7 |
| 关键词 | L-Alanine Intracellular amino-acid profile Human cervical carcinoma HeLa cell Taxol |
| 产权排序 | 1,1 |
| 通讯作者 | 肖红斌 |
| 英文摘要 | the anti-tumor action of taxol was investigated in the changes of amino-acids involved in tumor cell survival. by tracing the intracellular amino-acid profiles of hela cells treated with non-conditioned and three conditioned media (taxol, l-alanine, and taxol + l-alanine), it was observed that an alteration of amino-acid metabolism participates in taxol-induced death of hela cells. the contents of 18 out of 21 detected amino-acids are 5-95% and the ones of lysine and methionine are 158 and 117% of the corresponding contents in the control after treatment with taxol for 24 h, respectively. addition of l-alanine inhibited cell apoptosis upon taxol treatment by partially blocking the increase of lysine and methionine and reversing decrease trend of alanine, glycine, and glutamic acid. these results suggest that interference of amino-acid metabolism might be an important mechanism of taxol cytotoxicity. |
| WOS标题词 | science & technology ; life sciences & biomedicine |
| 学科主题 | 物理化学 |
| 类目[WOS] | biotechnology & applied microbiology |
| 研究领域[WOS] | biotechnology & applied microbiology |
| 关键词[WOS] | induced apoptosis ; cancer cells ; growth ; lysine ; deprivation ; imbalance |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000297862100001 |
| 公开日期 | 2013-10-11 |
| 源URL | [http://159.226.238.44/handle/321008/118191]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Han, Xiao-Fei,Liu, Yan-Qiu,Wang, Long-Xing,et al. Taxol-induced alteration of intracellular amino-acid profile related to human cervical carcinoma HeLa cell death[J]. biotechnology letters,2012,34(1):1-7. |
| APA | Han, Xiao-Fei,Liu, Yan-Qiu,Wang, Long-Xing,Yang, Qian-Xu,&Xiao, Hong-Bin.(2012).Taxol-induced alteration of intracellular amino-acid profile related to human cervical carcinoma HeLa cell death.biotechnology letters,34(1),1-7. |
| MLA | Han, Xiao-Fei,et al."Taxol-induced alteration of intracellular amino-acid profile related to human cervical carcinoma HeLa cell death".biotechnology letters 34.1(2012):1-7. |
入库方式： OAI收割
来源：大连化学物理研究所
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