BmK-YA, an Enkephalin-Like Peptide in Scorpion Venom
文献类型：期刊论文
| 作者 | Zhang, Yan1; Xu, Junyan2; Wang, Zhiwei1; Zhang, Xiuli2; Liang, Xinmiao2; Civelli, Olivier1,3,4 |
| 刊名 | plos one
 |
| 出版日期 | 2012-07-09 |
| 卷号 | 7期号:7页码:404171 |
| ISSN号 | 1932-6203 |
| 产权排序 | 2,2 |
| 通讯作者 | 梁鑫淼 ; civelliolivier |
| 英文摘要 | by screening extracts of venom from the asian scorpion buthus martensii karsch (bmk) for their abilities to activate opioid receptors, we have identified bmk-ya, an amidated peptide containing an enkephalin-like sequence. bmk-ya is encoded by a precursor that displays a signal sequence and contains four copies of bmk-ya sequences and four of his(4)-bmk-ya, all flanked by single amino acid residues. bmk-ya and his(4)-bmk-ya are amidated and thus fulfill the characteristics expected of bioactive peptides. bmk-ya can activate mammalian opioid receptors with selectivity for the delta subtype while his(4)-bmk-ya is inactive at opioid receptors. the discovery of bmk-ya suggests that scorpion venom may represent a novel source of bioactive molecules targeting g protein-coupled receptors (gpcrs) and reveal additional insights on the evolution of the opioid precursors. |
| 学科主题 | 物理化学 |
| 类目[WOS] | multidisciplinary sciences |
| 研究领域[WOS] | science & technology - other topics |
| 关键词[WOS] | buthus-martensii karsch ; molecular characterization ; opioid receptor ; 3-finger toxin ; identification ; neurotoxins ; proenkephalin ; antagonist ; exendin-4 ; channels |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000306354700045 |
| 公开日期 | 2013-10-11 |
| 源URL | [http://159.226.238.44/handle/321008/118208]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Univ Calif Irvine, Dept Pharmacol, Irvine, CA 92717 USA 2.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian, Peoples R China 3.Univ Calif Irvine, Dept Dev & Cell Biol, Irvine, CA 92717 USA 4.Univ Calif Irvine, Dept Pharmaceut Sci, Irvine, CA USA |
| 推荐引用方式 GB/T 7714 | Zhang, Yan,Xu, Junyan,Wang, Zhiwei,et al. BmK-YA, an Enkephalin-Like Peptide in Scorpion Venom[J]. plos one,2012,7(7):404171. |
| APA | Zhang, Yan,Xu, Junyan,Wang, Zhiwei,Zhang, Xiuli,Liang, Xinmiao,&Civelli, Olivier.(2012).BmK-YA, an Enkephalin-Like Peptide in Scorpion Venom.plos one,7(7),404171. |
| MLA | Zhang, Yan,et al."BmK-YA, an Enkephalin-Like Peptide in Scorpion Venom".plos one 7.7(2012):404171. |
入库方式： OAI收割
来源：大连化学物理研究所
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