Analysis of Urinary Metabolic Signatures of Early Hepatocellular Carcinoma Recurrence after Surgical Removal Using Gas Chromatography-Mass Spectrometry
文献类型：期刊论文
| 作者 | Ye, Guozhu1; Zhu, Bin2; Yao, Zhenzhen3; Yin, Peiyuan1; Lu, Xin1; Kong, Hongwei1; Fan, Fei2; Jiao, Binghua3; Xu, Guowang1 |
| 刊名 | journal of proteome research
 |
| 出版日期 | 2012-08-01 |
| 卷号 | 11期号:8页码:4361-4372 |
| 关键词 | urine metabolomics hepatocellular carcinoma GC-MS surgery metabolic signature recurrence |
| 产权排序 | 1, 1 |
| 通讯作者 | binghuajiao ; 许国旺 |
| 英文摘要 | the objective of present study was to offer insights into the metabolic responses of hepatocellular carcinoma (hcc) to surgical resection and the metabolic signatures latent in early hcc recurrence (one year after operation). urinary metabolic profiling employing gas chromatography time-of-flight mass spectrometry (gc-tof ms) was utilized to investigate the complex physiopathologic regulations in hcc after operational intervention. it was revealed that an intricate series of metabolic regulations including energy metabolism, amino acid metabolism, nucleoside metabolism, tricarboxylic acid (tca) cycle, gut floral metabolism, etc., principally leading to the direction of biomass synthesis, could be observed after tumor surgical removal. moreover, metabolic differences between recurrent and nonrecurrent patients had emerged 7 days after initial operation. the metabolic signatures of hcc recurrence principally comprised notable up-regulations of lactate excretion, succinate production, purine and pyrimidine nucleosides turnover, glycine, serine and threonine metabolism, aromatic amino acid turnover, cysteine and methionine metabolism, and glyoxylate metabolism, similar to metabolic behaviors of hcc burden. sixteen metabolites were found to be significantly increased in the recurrent patients compared with those in nonrecurrent patients and healthy controls. five metabolites (ethanolamine, lactic acid, acotinic acid, phenylalanine and ribose) were further defined; they were favorable to the prediction of early recurrence. |
| WOS标题词 | science & technology ; life sciences & biomedicine |
| 学科主题 | 物理化学 |
| 类目[WOS] | biochemical research methods |
| 研究领域[WOS] | biochemistry & molecular biology |
| 关键词[WOS] | breast-cancer ; cells ; metaboanalyst ; metabonomics ; ethanolamine ; metastasis ; profiles ; pathway ; choline ; rats |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000307037600040 |
| 公开日期 | 2013-10-11 |
| 源URL | [http://159.226.238.44/handle/321008/118228]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China 2.Second Mil Med Univ, Eastern Hepatobiliary Surg Hosp, Dept Biliary Surg 2, Shanghai 200438, Peoples R China 3.Second Mil Med Univ, Dept Biochem & Mol Biol, Shanghai 200433, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ye, Guozhu,Zhu, Bin,Yao, Zhenzhen,et al. Analysis of Urinary Metabolic Signatures of Early Hepatocellular Carcinoma Recurrence after Surgical Removal Using Gas Chromatography-Mass Spectrometry[J]. journal of proteome research,2012,11(8):4361-4372. |
| APA | Ye, Guozhu.,Zhu, Bin.,Yao, Zhenzhen.,Yin, Peiyuan.,Lu, Xin.,...&Xu, Guowang.(2012).Analysis of Urinary Metabolic Signatures of Early Hepatocellular Carcinoma Recurrence after Surgical Removal Using Gas Chromatography-Mass Spectrometry.journal of proteome research,11(8),4361-4372. |
| MLA | Ye, Guozhu,et al."Analysis of Urinary Metabolic Signatures of Early Hepatocellular Carcinoma Recurrence after Surgical Removal Using Gas Chromatography-Mass Spectrometry".journal of proteome research 11.8(2012):4361-4372. |
入库方式： OAI收割
来源：大连化学物理研究所
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