Serum metabolomics reveals the deregulation of fatty acids metabolism in hepatocellular carcinoma and chronic liver diseases
文献类型：期刊论文
| 作者 | Zhou, Lina1; Wang, Quancai2; Yin, Peiyuan1; Xing, Wenbin3; Wu, Zeming1; Chen, Shili1; Lu, Xin1; Zhang, Yong3; Lin, Xiaohui2; Xu, Guowang1 |
| 刊名 | analytical and bioanalytical chemistry
 |
| 出版日期 | 2012-04-01 |
| 卷号 | 403期号:1页码:203-213 |
| 关键词 | Hepatocellular carcinoma Metabolomic profiling Random forest-recursive feature elimination Acylcarnitine Fatty acid oxidation |
| 产权排序 | 1,1 |
| 通讯作者 | 许国旺 ; 林晓慧 |
| 英文摘要 | patients with chronic liver diseases (cld) including chronic hepatitis b and hepatic cirrhosis (cir) are the major high-risk population of hepatocellular carcinoma (hcc). the differential diagnosis between cld and hcc is a challenge. this work aims to study the related metabolic deregulations in hcc and cld to promote the discovery of the differential metabolites for distinguishing the different liver diseases. serum metabolic profiling analysis from patients with cld and hcc was performed using a liquid chromatography-mass spectrometry system. the acquired large amount of metabolic information was processed with the random forest-recursive feature elimination method to discover important metabolic changes. it was found that long-chain acylcarnitines accumulated, whereas free carnitine, medium and short-chain acylcarnitines decreased with the severity of the non-malignant liver diseases, accompanied with corresponding alterations of enzyme activities. however, the general changing extent was smaller in hcc than in cir, possibly due to the special energy-consumption mechanism of tumor cells. these observations may help to understand the mechanism of hcc occurrence and progression on the metabolic level and provide information for the identification of early and differential metabolic markers for hcc. |
| WOS标题词 | science & technology ; life sciences & biomedicine ; physical sciences |
| 学科主题 | 物理化学 |
| 类目[WOS] | biochemical research methods ; chemistry, analytical |
| 研究领域[WOS] | biochemistry & molecular biology ; chemistry |
| 关键词[WOS] | mass-spectrometry ; indoleamine 2,3-dioxygenase ; random forest ; molecular pathogenesis ; interferon-gamma ; virus-infection ; classification ; identification ; metabonomics ; pathway |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000301839700015 |
| 公开日期 | 2013-10-11 |
| 源URL | [http://159.226.238.44/handle/321008/118343]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China 2.Dalian Univ Technol, Sch Comp Sci & Technol, Dalian 116024, Peoples R China 3.Sixth Peoples Hosp, Dalian 116001, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Lina,Wang, Quancai,Yin, Peiyuan,et al. Serum metabolomics reveals the deregulation of fatty acids metabolism in hepatocellular carcinoma and chronic liver diseases[J]. analytical and bioanalytical chemistry,2012,403(1):203-213. |
| APA | Zhou, Lina.,Wang, Quancai.,Yin, Peiyuan.,Xing, Wenbin.,Wu, Zeming.,...&Xu, Guowang.(2012).Serum metabolomics reveals the deregulation of fatty acids metabolism in hepatocellular carcinoma and chronic liver diseases.analytical and bioanalytical chemistry,403(1),203-213. |
| MLA | Zhou, Lina,et al."Serum metabolomics reveals the deregulation of fatty acids metabolism in hepatocellular carcinoma and chronic liver diseases".analytical and bioanalytical chemistry 403.1(2012):203-213. |
入库方式： OAI收割
来源：大连化学物理研究所
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