Intestinal Transport of Pure Diester-type Alkaloids from an Aconite Extract across the Caco-2 Cell Monolayer Model
文献类型：期刊论文
| 作者 | Li, Na1,2; Tsao, Rong3; Sui, Zhigang2; Ma, Jingwei1; Liu, Zhiqiang4; Liu, Zhongying1 |
| 刊名 | planta medica
 |
| 出版日期 | 2012-05-01 |
| 卷号 | 78期号:7页码:692-697 |
| 关键词 | Aconitum species Ranunculaceae Aconitum alkaloids intestinal transport Caco-2 cell monolayer P-glycoprotein |
| ISSN号 | 0032-0943 |
| 产权排序 | 2,1 |
| 通讯作者 | zhongyingliu |
| 英文摘要 | aconitine (ac), mesaconitine (ma), and hypaconitine (ha) are the active alkaloids identified in aconite tuber, an important traditional chinese medicine. the study is aimed to investigate their intestinal transport profiles and potential interaction during the intestinal absorption using the caco-2 cell monolayer model. all three alkaloids had good permeability with p-app values greater than 1 x 10(-6) cm.s(-1). however, ac, ma, and ha in a mixture and as an extract, in both cases with the same content of alkaloids, showed higher transport efficiency in the apical to basolateral, and lower transport efficiency in the basolateral to apical directions. digoxin, as a p-glycoprotein (p-gp) substrate, was substantially effluxed in the basolateral to apical direction but inhibited by the three alkaloids. furthermore, the backwards transport of ma and ha was inhibited by the p-gp inhibitor verapamil. these observations indicated that the three alkaloids may not only be p-gp inhibitors but also its substrates; they interact with each other and can potentially enhance their own bioavailability when taken concomitantly. |
| WOS标题词 | science & technology ; life sciences & biomedicine |
| 学科主题 | 物理化学 |
| 类目[WOS] | plant sciences ; chemistry, medicinal ; pharmacology & pharmacy |
| 研究领域[WOS] | plant sciences ; pharmacology & pharmacy |
| 关键词[WOS] | performance liquid-chromatography ; p-glycoprotein ; quantitative-determination ; drug interactions ; in-vitro ; diterpenoid alkaloids ; mediated transport ; hypaconitine ; permeability ; mesaconitine |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000303838000008 |
| 公开日期 | 2013-10-11 |
| 源URL | [http://159.226.238.44/handle/321008/118383]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Jilin Univ, Coll Pharm, Changchun 130021, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116012, Peoples R China 3.Agr & Agri Food Canada, Guelph Food Res Ctr, Guelph, ON, Canada 4.Chinese Acad Sci, Changchun Inst Appl Chem, Changchun Ctr Mass Spectrometry, Changchun 130022, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Na,Tsao, Rong,Sui, Zhigang,et al. Intestinal Transport of Pure Diester-type Alkaloids from an Aconite Extract across the Caco-2 Cell Monolayer Model[J]. planta medica,2012,78(7):692-697. |
| APA | Li, Na,Tsao, Rong,Sui, Zhigang,Ma, Jingwei,Liu, Zhiqiang,&Liu, Zhongying.(2012).Intestinal Transport of Pure Diester-type Alkaloids from an Aconite Extract across the Caco-2 Cell Monolayer Model.planta medica,78(7),692-697. |
| MLA | Li, Na,et al."Intestinal Transport of Pure Diester-type Alkaloids from an Aconite Extract across the Caco-2 Cell Monolayer Model".planta medica 78.7(2012):692-697. |
入库方式： OAI收割
来源：大连化学物理研究所
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