Effects of oligo-porphyran on immunological parameters related to immunoregulation and growth in RAW264.7 macrophages and zebrafish model
文献类型：期刊论文
| 作者 | Wang, Xiaoqing1,2; Wei, Maosheng1,2; Wang, Jing1,3 ; Liu, Jing1,4; Zhang, Quanbin1,3
|
| 刊名 | AQUACULTURE INTERNATIONAL
 |
| 出版日期 | 2022-10-19 |
| 页码 | 17 |
| 关键词 | Oligo-porphyran Immunological parameters RAW264 7 macrophages Zebrafish model |
| ISSN号 | 0967-6120 |
| DOI | 10.1007/s10499-022-00999-0 |
| 通讯作者 | Liu, Jing(jingwang@qdio.ac.cn) |
| 英文摘要 | Many carbohydrate compounds derived from marine seaweeds possess immune-enhancing activities. In recent years, the effect of dietary addition of marine polysaccharides on fish has been widely evaluated. Here, we studied the immunoregulation potential of oligo-porphyran (OP) through LPS-induced RAW264.7 cells and zebrafish model. Surprisingly, we found that OP had an excellent anti-inflammatory effect with a dose-dependent manner in vitro. OP administration effectively reduced LPS-induced NO release and inflammatory cytokine production in RAW264.7 cells. Notably, we also found that dietary OP to zebrafish exerted positive effect on intestinal immunity through regulating immune factor content and gut microbiota. Besides, dietary OP could also maintain steadiness of intestinal morphology of zebrafish, enhance the intestinal digestive enzyme activity, and promote the accumulation of crude protein and crude fat in zebrafish. These findings indicated that OP supplementation in diet could promote growth, improve immunity, and regulate intestinal flora, which made OP a promising aquatic candidate additive. |
| 资助项目 | National Key research and Development Program of China[2019YFD0900705] |
| WOS研究方向 | Fisheries |
| 语种 | 英语 |
| WOS记录号 | WOS:000870108800001 |
| 出版者 | SPRINGER |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/180635]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Liu, Jing |
| 作者单位 | 1.Chinese Acad Sci, Ctr Ocean Megasci, Inst Oceanol, CAS & Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China 4.Qingdao Agr Univ, Qingdao, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Xiaoqing,Wei, Maosheng,Wang, Jing,et al. Effects of oligo-porphyran on immunological parameters related to immunoregulation and growth in RAW264.7 macrophages and zebrafish model[J]. AQUACULTURE INTERNATIONAL,2022:17. |
| APA | Wang, Xiaoqing,Wei, Maosheng,Wang, Jing,Liu, Jing,&Zhang, Quanbin.(2022).Effects of oligo-porphyran on immunological parameters related to immunoregulation and growth in RAW264.7 macrophages and zebrafish model.AQUACULTURE INTERNATIONAL,17. |
| MLA | Wang, Xiaoqing,et al."Effects of oligo-porphyran on immunological parameters related to immunoregulation and growth in RAW264.7 macrophages and zebrafish model".AQUACULTURE INTERNATIONAL (2022):17. |
入库方式： OAI收割
来源：海洋研究所
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