Temperature induces metabolic reprogramming in fish during bacterial infection
文献类型：期刊论文
| 作者 | Sun, Bin1,2 ; Sun, Boguang1,3; Zhang, Beibei1,4; Sun, Li1,3,5
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| 刊名 | FRONTIERS IN IMMUNOLOGY
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| 出版日期 | 2022-09-15 |
| 卷号 | 13页码:16 |
| 关键词 | Paralichthys olivaceus metabolism edwardsiellosis temperature global warming biomarker Edwardsiella bacterial infection |
| ISSN号 | 1664-3224 |
| DOI | 10.3389/fimmu.2022.1010948 |
| 通讯作者 | Sun, Boguang() ; Sun, Li(lsun@qdio.ac.cn) |
| 英文摘要 | Water temperature elevation as a consequence of global warming results in increased incidence of bacterial disease, such as edwardsiellosis, in fish farming. Edwardsiellosis is caused by the bacterial pathogen Edwardsiella tarda and affects many farmed fish including flounder (Paralichthys olivaceus). Currently, the effect of temperature on the metabolic response of flounder to E. tarda infection is unclear. In this study, we found that compared to low temperature (15 degrees C), high temperature (23 degrees C) enhanced E. tarda dissemination in flounder tissues. To examine the impact of temperature on the metabolism of flounder induced by E. tarda, comparative metabolomics were performed, which identified a large number of metabolites responsive to E. tarda invasion and temperature alteration. During E. tarda infection, the metabolic profile induced by elevated temperature was mainly featured by extensively decreased amino acids and TCA intermediates such as succinate, a proven immune regulator. Further, 38 potential metabolite markers of temperature effect (MMTE) in association with bacterial infection were identified. When used as exogenous supplements, two of the MMTE, i.e., L-methionine and UDP-glucose, effectively upregulated the expression of pro-inflammatory cytokines and suppressed E. tarda infection in flounder leukocytes. Taken together, the results of this study indicate an important influence of temperature on the metabolism of flounder during bacterial infection, which eventually affects the survivability of the fish. |
| 资助项目 | National Key R&D Program of China ; National Natural Science Foundation of China ; Taishan Scholar Program of Shandong Province ; [2018YFD0900500] ; [41876170] |
| WOS研究方向 | Immunology |
| 语种 | 英语 |
| WOS记录号 | WOS:000862097800001 |
| 出版者 | FRONTIERS MEDIA SA |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/180711]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Sun, Boguang; Sun, Li |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, CAS Key Lab Expt Marine Biol, Qingdao, Peoples R China 2.Fujian Polytech Normal Univ, Inst Ocean Res, Fuqing, Peoples R China 3.Pilot Natl Lab Marine Sci & Technol Qingdao, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China 4.Qingdao Agr Univ, Coll Anim Sci & Technol, Qingdao, Peoples R China 5.Univ Chinese Acad Sci, Coll Earth & Planetary Sci, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun, Bin,Sun, Boguang,Zhang, Beibei,et al. Temperature induces metabolic reprogramming in fish during bacterial infection[J]. FRONTIERS IN IMMUNOLOGY,2022,13:16. |
| APA | Sun, Bin,Sun, Boguang,Zhang, Beibei,&Sun, Li.(2022).Temperature induces metabolic reprogramming in fish during bacterial infection.FRONTIERS IN IMMUNOLOGY,13,16. |
| MLA | Sun, Bin,et al."Temperature induces metabolic reprogramming in fish during bacterial infection".FRONTIERS IN IMMUNOLOGY 13(2022):16. |
入库方式： OAI收割
来源：海洋研究所
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