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Cyclopiumolides A and B, unusual 13-membered macrolides from the deep sea-sourced fungus Penicillium cyclopium SD-413 with antiproliferative activities

文献类型：期刊论文

作者Li, Yan-He1,2,3,4; Yang, Sui-Qun1,2,3; Li, Xiao-Ming1,2,3; Li, Xin1,2,3; Wang, Bin-Gui1,2,3,4,5,6; Li, Hong-Lei1,2,3,6
刊名BIOORGANIC CHEMISTRY
出版日期2022-11-01
卷号128页码:7
ISSN号0045-2068
关键词Macrolides Penicillium cyclopium Deep-sea sediment Cytotoxicity
DOI10.1016/j.bioorg.2022.106104
通讯作者Wang, Bin-Gui(wangbg@ms.qdio.ac.cn) ; Li, Hong-Lei(lihonglei@qdio.ac.cn)
英文摘要Cyclopiumolides A (1) and B (2), first representatives of two novel biosynthetic related 13-membered macrolides featuring an uncommon verrucosidinol unit condensed with a spiculisporic acidic moiety, were identified from the fungus Penicillium cyclopium SD-413, which was obtained from the deep-sea sediments collected in the East China Sea. The structures of cyclopiumolides A (1) and B (2) were identified on the basis of extensive NMR spectroscopic and mass spectrometric data analysis. Their relative and absolute configurations were determined by quantum mechanical calculations of ECD spectra comparing with that of experimental curves and by DP4 + NMR data calculations. Compounds 1 and 2 exhibited significant cytotoxic potencies against the tumor cell lines SF126, FaDu, and TE-1 with IC50 values ranging from 5.86 to 17.05 mu M. The inhibition modes and binding sites of 1 and 2 were inspected using molecular docking simulations.
资助项目National Natural Science Foundation of China[U2006203] ; National Natural Science Foundation of China[42076090] ; Shandong Provincial Natural Science Foundation[ZR2021ZD28] ; National Major Science and Technology Infrastructure from the Chinese Academy of Sciences ; Senior User Project of RV KEXUE[KEXUE2020GZ02] ; RV KEXUE of the National Major Science and Technology Infrastructure ; Chinese Academy of Sciences
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
语种英语
出版者ACADEMIC PRESS INC ELSEVIER SCIENCE
WOS记录号WOS:000859336700004
源URL[http://ir.qdio.ac.cn/handle/337002/180726]  
专题海洋研究所_实验海洋生物学重点实验室
通讯作者Wang, Bin-Gui; Li, Hong-Lei
作者单位1.Chinese Acad Sci, Nanhai Rd 7, Qingdao 266071, Peoples R China
2.Inst Oceanol, Chinese Acad Sci, Shandong Prov Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China
3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Wenhai Rd 1, Qingdao 266237, Peoples R China
4.Univ Chinese Acad Sci, Coll Marine Sci, Yuquan Rd 19A, Beijing 100049, Peoples R China
5.Chinese Acad Sci, Ctr Ocean Megasci, Nanhai Rd 7, Qingdao 266071, Peoples R China
6.Inst Oceanol, Chinese Acad Sci, Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China
推荐引用方式
GB/T 7714		 Li, Yan-He,Yang, Sui-Qun,Li, Xiao-Ming,et al. Cyclopiumolides A and B, unusual 13-membered macrolides from the deep sea-sourced fungus Penicillium cyclopium SD-413 with antiproliferative activities[J]. BIOORGANIC CHEMISTRY,2022,128:7.
APA Li, Yan-He,Yang, Sui-Qun,Li, Xiao-Ming,Li, Xin,Wang, Bin-Gui,&Li, Hong-Lei.(2022).Cyclopiumolides A and B, unusual 13-membered macrolides from the deep sea-sourced fungus Penicillium cyclopium SD-413 with antiproliferative activities.BIOORGANIC CHEMISTRY,128,7.
MLA Li, Yan-He,et al."Cyclopiumolides A and B, unusual 13-membered macrolides from the deep sea-sourced fungus Penicillium cyclopium SD-413 with antiproliferative activities".BIOORGANIC CHEMISTRY 128(2022):7.

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来源：海洋研究所

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