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Blockage of PPAR gamma T166 phosphorylation enhances the inducibility of beige adipocytes and improves metabolic dysfunctions

文献类型：期刊论文

作者Yang, Nanfei8,9; Wang, Yuxin9; Tian, Qiang9; Wang, Qiuping9; Lu, Yan9; Sun, Luchen9; Wang, Sijie9; Bei, Yuncheng9; Ji, Jianguo7; Zhou, Hu5,6
刊名CELL DEATH AND DIFFERENTIATION
出版日期2022-11-03
页码13
ISSN号1350-9047
DOI10.1038/s41418-022-01077-x
通讯作者Li, Xiaokun(xiaokunli@wmu.edu.cn) ; Shen, Pingping(ppshen@nju.edu.cn)
英文摘要Beige adipocytes in mammalian white adipose tissue (WAT) can reinforce fat catabolism and energy expenditure. Promoting beige adipocyte biogenesis is a tantalizing tactic for combating obesity and its associated metabolic disorders. Here, we report that a previously unidentified phosphorylation pattern (Thr166) in the DNA-binding domain of PPAR gamma regulates the inducibility of beige adipocytes. This unique posttranslational modification (PTM) pattern influences allosteric communication between PPAR gamma and DNA or coactivators, which impedes the PPAR gamma-mediated transactivation of beige cell-related gene expression in WAT. The genetic mutation mimicking T166 phosphorylation (p-T166) hinders the inducibility of beige adipocytes. In contrast, genetic or chemical intervention in this PTM pattern favors beige cell formation. Moreover, inhibition of p-T166 attenuates metabolic dysfunction in obese mice. Our results uncover a mechanism involved in beige cell fate determination. Moreover, our discoveries provide a promising strategy for guiding the development of novel PPAR gamma agonists for the treatment of obesity and related metabolic disorders.
WOS关键词ACTIVATED RECEPTOR-GAMMA ; WHITE ADIPOSE-TISSUE ; BROWN ; FAT ; THERMOGENESIS ; INFLAMMATION ; HOMEOSTASIS ; EXPRESSION ; LIGAND ; ROLES
资助项目National Key Research and Development Plan[2017YFA0506000] ; Natural Science Foundation of Jiangsu Province[BK20222009] ; Guangdong Basic and Applied Basic Research Foundation[2021B1515120016] ; China Postdoctoral Science Foundation[2022M712436]
WOS研究方向Biochemistry & Molecular Biology ; Cell Biology
语种英语
出版者SPRINGERNATURE
WOS记录号WOS:000878453300002
源URL[http://119.78.100.183/handle/2S10ELR8/302876]  
专题中国科学院上海药物研究所
通讯作者Li, Xiaokun; Shen, Pingping
作者单位1.Nanjing Univ, Shenzhen Res Inst, Shenzhen 518000, Peoples R China
2.Wenzhou Med Univ, Oujiang Lab, Zhejiang Lab Regenerat Med Vis & Brain Hlth, Wenzhou 325035, Zhejiang, Peoples R China
3.Nanjing Univ, Med Sch, Dept Rheumatol & Immunol, Affiliated Drum Tower Hosp, 321 Zhongshan Rd, Nanjing 210008, Peoples R China
4.Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA
5.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China
6.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Analyt Chem, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China
7.Peking Univ, Sch Life Sci, State Key Lab Prot & Plant Gene Res, Beijing 100871, Peoples R China
8.Wenzhou Med Univ, Sch Pharmaceut Sci, Wenzhou 325035, Zhejiang, Peoples R China
9.Nanjing Univ, Med Sch,Dept Rheumatol & Immunol, Affiliated Hosp,State Key Lab Pharmaceut Biotechn, Sch Life Sci,Affiliated Nanjing Drum Tower Hosp, Nanjing 210023, Peoples R China
推荐引用方式
GB/T 7714		 Yang, Nanfei,Wang, Yuxin,Tian, Qiang,et al. Blockage of PPAR gamma T166 phosphorylation enhances the inducibility of beige adipocytes and improves metabolic dysfunctions[J]. CELL DEATH AND DIFFERENTIATION,2022:13.
APA Yang, Nanfei.,Wang, Yuxin.,Tian, Qiang.,Wang, Qiuping.,Lu, Yan.,...&Shen, Pingping.(2022).Blockage of PPAR gamma T166 phosphorylation enhances the inducibility of beige adipocytes and improves metabolic dysfunctions.CELL DEATH AND DIFFERENTIATION,13.
MLA Yang, Nanfei,et al."Blockage of PPAR gamma T166 phosphorylation enhances the inducibility of beige adipocytes and improves metabolic dysfunctions".CELL DEATH AND DIFFERENTIATION (2022):13.

入库方式： OAI收割

来源：上海药物研究所

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