Arylnaphthalide lignans from Saussurea medusa and their anti-inflammatory activities
文献类型：期刊论文
| 作者 | Cao, Jing-Ya4,5; Dong, Qi5; Wang, Zhi-Yao3; Zhao, Ye2; Ren, Yu2; Liu, Chang2; Dang, Jun5; Yu, Rui-Tao1,5; Tao, Yan-Duo1,5 |
| 刊名 | ARABIAN JOURNAL OF CHEMISTRY
 |
| 出版日期 | 2022-10-01 |
| 卷号 | 15期号:10页码:11 |
| ISSN号 | 1878-5352 |
| 关键词 | Saussurea medusa Arylnaphthalide lignan Anti-inflammatory activity ECD calculation Molecular docking |
| DOI | 10.1016/j.arabjc.2022.104155 |
| 通讯作者 | Yu, Rui-Tao(yuruitao@nwipb.cas.cn) ; Tao, Yan-Duo(tyd@nwipb.cas.cn) |
| 英文摘要 | Five new arylnaphthalide lignans (1 -4a/4b), together with five known analogues (5-9), were isolated from whole plants of Saussurea medusa. Compound 4 was characterized as an arylte-tralin lignan with an unusual C-7'-C-9 oxygen bridge group, and a chiral HPLC analysis was carried out to afford one pair of enantiomers (4a/4b). Structures of the new compounds were elucidated by extensive spectroscopic and electronic circular dichroism (ECD) calculations. All compounds were firstly isolated from S. medusa, and compounds 1-5, 7 and 8 had never been obtained from the genus Saussurea previously. Furthermore, this is the first report of arylnaphthalide lignans isolated from S. medusa. anti-inflammatory activities of the compounds were evaluated by determining their inhibitory activities on the production of NO by LPS-stimulated RAW 264.7 cells. Compounds (-)-4a and 5 exerted the significant inhibition activities with IC50 values of 13.4 +/- 1.5 and 15.7 +/- 1. 1 lM, respectively, which even exceeded the positive control quercetin (IC50 = 15.9 +/- 1.2 lM). Compounds 2, (+)-4b, 6 and 9 exhibited moderate inhibitory activities with IC50 values ranging from 19.7 +/- 1.9 to 47.4 +/- 3.1 lM. Further analysis by molecular docking showed that almost all the active compounds could interact with the amino acid residues of iNOS proteins, which also supported their anti-inflammatory activities.(c) 2022 The Authors. Published by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| WOS关键词 | NITRIC-OXIDE ; BIOACTIVE CONSTITUENTS ; PHENOLIC-COMPOUNDS ; GLYCOSIDES |
| 资助项目 | Natural Science Foundation of Qinghai Province[2022-ZJ-930] ; science and innovation platform for the development and construction of special project of Key Laboratory of Tibetan Medicine Research of Qinghai Province[2022-ZJ-Y03] ; Key R & D and promotion projects in Henan Province (tack- ling key scientific and technological problems)[212102310352] ; basic scientific research project of Henan Academy of Sciences[220613048] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| 出版者 | ELSEVIER |
| WOS记录号 | WOS:000878102400002 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/302888]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Yu, Rui-Tao; Tao, Yan-Duo |
| 作者单位 | 1.Chinese Acad Sci, Northwest Inst Plateau Biol, Xining, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China 3.Henan Acad Sci, Zhengzhou 450002, Peoples R China 4.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 5.Chinese Acad Sci, Northwest Inst Plateau Biol, Qinghai Prov Key Lab Tibetan Med Res, Key Lab Tibetan Med Res, Xining 810008, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cao, Jing-Ya,Dong, Qi,Wang, Zhi-Yao,et al. Arylnaphthalide lignans from Saussurea medusa and their anti-inflammatory activities[J]. ARABIAN JOURNAL OF CHEMISTRY,2022,15(10):11. |
| APA | Cao, Jing-Ya.,Dong, Qi.,Wang, Zhi-Yao.,Zhao, Ye.,Ren, Yu.,...&Tao, Yan-Duo.(2022).Arylnaphthalide lignans from Saussurea medusa and their anti-inflammatory activities.ARABIAN JOURNAL OF CHEMISTRY,15(10),11. |
| MLA | Cao, Jing-Ya,et al."Arylnaphthalide lignans from Saussurea medusa and their anti-inflammatory activities".ARABIAN JOURNAL OF CHEMISTRY 15.10(2022):11. |
入库方式： OAI收割
来源：上海药物研究所
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