Bioactive Cembranoids from the Coral Sarcophyton trocheliophorum of Ximao Island
文献类型：期刊论文
| 作者 | Zeng, Zi-Rong2,3; Chen, Jing3 ; Wang, Hong2; Zhang, Hai-Yan3; Li, Jia1,3; Xu, Baofu1,3; Guo, Yue-Wei1,3
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| 刊名 | ACS OMEGA
 |
| 出版日期 | 2022-11-02 |
| 页码 | 9 |
| ISSN号 | 2470-1343 |
| DOI | 10.1021/acsomega.2c05687 |
| 通讯作者 | Xu, Baofu(bfxu@simm.ac.cn) ; Guo, Yue-Wei(ywguo@simm.ac.cn) |
| 英文摘要 | Eight new cembranoids (sarcophytembranoids A-H, 1-8) and 10 known terpenoids (9-18) were obtained from the soft coral Sarcophyton trocheliophorum of Ximao Island. Notably, 11, 15, and 16 were obtained from a natural source for the first time. The structures of the new isolates were elucidated by extensive spectroscopic analysis, optical rotatory dispersion, and X-ray diffraction experiments. Although the isolated compounds did not show significant activity against the tested tumor cell lines, compounds 3, 7, 8, and 10-15 exhibited anti-inflammatory activities at 10 mu M, and compounds 17 and 18 showed moderate protein tyrosine phosphatase 1B inhibition activities with the minimum inhibitory concentrations of 22.19 and 11.26 mu M, respectively. |
| WOS关键词 | ANTI-TUMOR-PROMOTER ; SOFT CORAL ; MARINE TERPENES ; DITERPENES ; MARENZELLER |
| 资助项目 | National Natural Science Foundation of China (NSFC) ; SKLDR/SIMM Project ; Zhejiang Province ? ; Ten Thousand Talents Program? ; Science and Technology Innovation Leading Talent Project ; Shanghai Institute of Materia Medica of the Chinese Academy of Sciences ; [81991521] ; [SIMM1903ZZ-06] ; [2019R52009] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000879535900001 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/302897]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Xu, Baofu; Guo, Yue-Wei |
| 作者单位 | 1.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Peoples R China 2.Zhejiang Univ Technol, Coll Pharmaceut Sci, Collaborat Innovat Ctr Yangtze River Delta Reg Gre, Hangzhou 310014, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zeng, Zi-Rong,Chen, Jing,Wang, Hong,et al. Bioactive Cembranoids from the Coral Sarcophyton trocheliophorum of Ximao Island[J]. ACS OMEGA,2022:9. |
| APA | Zeng, Zi-Rong.,Chen, Jing.,Wang, Hong.,Zhang, Hai-Yan.,Li, Jia.,...&Guo, Yue-Wei.(2022).Bioactive Cembranoids from the Coral Sarcophyton trocheliophorum of Ximao Island.ACS OMEGA,9. |
| MLA | Zeng, Zi-Rong,et al."Bioactive Cembranoids from the Coral Sarcophyton trocheliophorum of Ximao Island".ACS OMEGA (2022):9. |
入库方式： OAI收割
来源：上海药物研究所
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