中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 上海药物研究所
  3. 中国科学院上海药物研究所
Self-Cooperative Prodrug Nanovesicles Migrate Immune Evasion to Potentiate Chemoradiotherapy in Head and Neck Cancer

文献类型：期刊论文

作者Zhu, Yun1,5,6; Zhang, Shunan1,4; Lai, Yi1,3; Pan, Jiaxing1; Chen, Fangmin1; Wang, Tingting2; Wang, Fengyang2; Xu, Zhiai4; Yang, Wenjun5,6; Yu, Haijun1
刊名ADVANCED SCIENCE
出版日期2022-11-07
页码13
关键词chemoradiotherapy cooperative therapy head and neck cancer immune evasion immunogenic cell death
DOI10.1002/advs.202203263
通讯作者Lai, Yi(laiyi@simm.ac.cn) ; Yang, Wenjun(ywjdoctor@sjtu.edu.cn) ; Yu, Haijun(hjyu@simm.ac.cn)
英文摘要Chemoradiotherapy is the standard of care for the clinical treatment of locally advanced head and neck cancers. However, the combination of ion radiation with free chemotherapeutics yields unsatisfactory therapeutic output and severe side effects due to the nonspecific biodistribution of the anticancer drugs. Herein, a self-cooperative prodrug nanovesicle is reported for highly tumor-specific chemoradiotherapy. The nanovesicles integrating a prodrug of oxaliplatin (OXA) can passively accumulate at the tumor site and penetrate deep into the tumor mass via matrix metalloproteinase 2-mediated cleavage of the polyethylene glycol corona. The OXA prodrug can be restored inside the tumor cells with endogenous glutathione to trigger immunogenic cell death (ICD) of the tumor cells and sensitize the tumor to ion radiation. The nanovesicles can be further loaded with the JAK inhibitor ruxolitinib to abolish chemoradiotherapy-induced programmed death ligand 1 (PD-L1) upregulation on the surface of the tumor cells, thereby prompting chemoradiotherapy-induced immunotherapy by blocking the interferon gamma-Janus kinase-signal transducer and activator of transcription axis. The prodrug nanoplatform reported herein might present a novel strategy to cooperatively enhance chemoradiotherapy of head and cancer and overcome PD-L1-dependent immune evasion.
WOS关键词SQUAMOUS-CELL CARCINOMA ; PD-L1 EXPRESSION ; NANOPARTICLES ; RESISTANCE ; NIVOLUMAB
资助项目National Natural Science Foundation of China[51873228] ; National Natural Science Foundation of China[52003194] ; National Natural Science Foundation of China[82102915] ; Science Foundation of Shanghai Science and Technology Commission[20430711800] ; Science Foundation of Shanghai Science and Technology Commission[21ZR1437900] ; China Postdoctoral Science Foundation[2021M700157] ; Shanghai Post-Doctoral Excellence Program[2021424] ; Lingang Laboratory[LG-QS-202206-04] ; Open Research Fund of State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences[2019-027] ; biobank program of Shanghai Ninth people's hospital[YBKA201905]
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science
语种英语
出版者WILEY
WOS记录号WOS:000879606500001
源URL[http://119.78.100.183/handle/2S10ELR8/302906]  
专题中国科学院上海药物研究所
通讯作者Lai, Yi; Yang, Wenjun; Yu, Haijun
作者单位1.Chinese Acad Sci, Ctr Pharmaceut, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
2.Tongji Univ, Dept Med Ultrasound, Shanghai Peoples Hosp 10, Shanghai 200072, Peoples R China
3.Fudan Univ, Huadong Hosp, Shanghai Med Coll, Dept Gastroenterol, Shanghai 200040, Peoples R China
4.East China Normal Univ, Sch Chem & Mol Engn, Shanghai 200241, Peoples R China
5.Natl Clin Res Ctr Oral Dis, Shanghai Key Lab Stomatol, Shanghai 200011, Peoples R China
6.Shanghai Jiao Tong Univ, Peoples Hosp 9, Dept Oral & Maxillofacial Head & Neck Oncol, Coll Stomatol,Sch Med, Shanghai 200011, Peoples R China
推荐引用方式
GB/T 7714		 Zhu, Yun,Zhang, Shunan,Lai, Yi,et al. Self-Cooperative Prodrug Nanovesicles Migrate Immune Evasion to Potentiate Chemoradiotherapy in Head and Neck Cancer[J]. ADVANCED SCIENCE,2022:13.
APA Zhu, Yun.,Zhang, Shunan.,Lai, Yi.,Pan, Jiaxing.,Chen, Fangmin.,...&Yu, Haijun.(2022).Self-Cooperative Prodrug Nanovesicles Migrate Immune Evasion to Potentiate Chemoradiotherapy in Head and Neck Cancer.ADVANCED SCIENCE,13.
MLA Zhu, Yun,et al."Self-Cooperative Prodrug Nanovesicles Migrate Immune Evasion to Potentiate Chemoradiotherapy in Head and Neck Cancer".ADVANCED SCIENCE (2022):13.

入库方式： OAI收割

来源：上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。