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Comprehensive landscape of the ST3GAL family reveals the significance of ST3GAL6-AS1/ST3GAL6 axis on EGFR signaling in lung adenocarcinoma cell invasion

文献类型：期刊论文

作者Li, Jiaxuan1,7; Long, Yiming5,6; Sun, Jingya6; Wu, Jiajun4; He, Xiao3,6; Wang, Simei5,6; Wang, Xiongbiao2,7; Miao, Xiayi7; Huang, Ruimin3,5,6; Yan, Jun4,7
刊名FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
出版日期2022-08-26
卷号10页码:17
关键词lung adenocarcinoma sialyltransferase prognostic analysis ST3GAL6 ST3GAL6-AS1
ISSN号2296-634X
DOI10.3389/fcell.2022.931132
通讯作者Miao, Xiayi(miaoxiayi@shutcm.edu.cn) ; Huang, Ruimin(rmhuang@simm.ac.cn) ; Yan, Jun(yan_jun@fudan.edu.cn)
英文摘要Sialylation aberration has been implicated in lung cancer development by altering signaling pathways. Hence, it is urgent to identify key sialyltransferases in the development of lung adenocarcinoma (LUAD), which is a common malignant subtype of non-small cell lung cancer. Herein, by systematically investigating the expression levels of ST3GAL family members in several public databases, we consistently found the frequent downregulation of ST3GAL6 in LUAD samples. Its downregulation is significantly negatively associated with stage, and significantly reduced in proximal-proliferative molecular subtype and predicts poor clinical outcomes. By protein-protein interaction network analysis and validation, we found that ST3GAL6 deficiency promotes LUAD cell invasiveness with the activated EGFR/MAPK signaling, accompanied by the elevated expression levels of matrix metalloproteinases 2 and 9, which can be partially reversed by EGFR inhibitor, gefitinib. Additionally, the ST3GAL6 level was positively regulated by ST3GAL6-AS1, an antisense long non-coding RNA to its host gene. The downregulation of ST3GAL6-AS1 also heralds a worse prognosis in LUAD patients and promotes LUAD cell invasiveness, recapitulating the function of its host gene, ST3GAL6. Altogether, ST3GAL6-AS1-regulated ST3GAL6 is a frequently downregulated sialyltransferase in LUAD patients and negatively regulates EGFR signaling, which can serve as a promising independent prognostic marker in LUAD patients.
WOS关键词BLADDER-CANCER CELLS ; GENE-EXPRESSION ; GROWTH ; SIALYLATION ; MIGRATION ; SIALYLTRANSFERASES ; VALIDATION ; ACTIVATION ; SURVIVAL ; PACKAGE
资助项目National Natural Science Foundation of China ; Shanghai Sailing Program[82172001] ; Shanghai Sailing Program[81902968] ; Plan of Clinical Specialty Construction in Shanghai Putuo District Health System[19YF1456900] ; Clinical Research Special Project of Shanghai Municipal Health Commission[2020tszk02] ; Shanghai Municipal Science and Technology Major Project[20214Y0495] ; Shanghai Science and Technology Committee ; [20S11901400]
WOS研究方向Cell Biology ; Developmental Biology
语种英语
WOS记录号WOS:000882995900001
出版者FRONTIERS MEDIA SA
源URL[http://119.78.100.183/handle/2S10ELR8/302912]  
专题中国科学院上海药物研究所
通讯作者Miao, Xiayi; Huang, Ruimin; Yan, Jun
作者单位1.Fudan Univ, Shanghai Inst Infect Diseaseand Biosecur, Shanghai, Peoples R China
2.Shanghai Univ Tradit Chinese Med, Intervent Canc Inst Chinese Integrat Med, Shanghai, Peoples R China
3.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing, Peoples R China
4.Fudan Univ, Dept Lab Anim Sci, Shanghai, Peoples R China
5.Univ Chinese Acad Sci, Beijing, Peoples R China
6.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai, Peoples R China
7.Shanghai Univ Tradit Chinese Med, Putuo Hosp, Dept Resp Med, Shanghai, Peoples R China
推荐引用方式
GB/T 7714		 Li, Jiaxuan,Long, Yiming,Sun, Jingya,et al. Comprehensive landscape of the ST3GAL family reveals the significance of ST3GAL6-AS1/ST3GAL6 axis on EGFR signaling in lung adenocarcinoma cell invasion[J]. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY,2022,10:17.
APA Li, Jiaxuan.,Long, Yiming.,Sun, Jingya.,Wu, Jiajun.,He, Xiao.,...&Yan, Jun.(2022).Comprehensive landscape of the ST3GAL family reveals the significance of ST3GAL6-AS1/ST3GAL6 axis on EGFR signaling in lung adenocarcinoma cell invasion.FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY,10,17.
MLA Li, Jiaxuan,et al."Comprehensive landscape of the ST3GAL family reveals the significance of ST3GAL6-AS1/ST3GAL6 axis on EGFR signaling in lung adenocarcinoma cell invasion".FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY 10(2022):17.

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来源：上海药物研究所

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