Two new xanthones from Hypericum japonicum and their lipid-lowering activities
文献类型：期刊论文
| 作者 | Guo, Peng-Ju2,3; Chen, Tong1,3; Zheng, Liu2,3; Peng, Shou2,3; Lv, Kai-Qing1,3; Wang, Wen-Qiong3; Xuan, Li-Jiang2,3
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| 刊名 | PHYTOCHEMISTRY LETTERS
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| 出版日期 | 2022-06-01 |
| 卷号 | 49页码:40-44 |
| ISSN号 | 1874-3900 |
| 关键词 | Hypericum japonicum Guttiferae Xanthones Lipid-lowering activity |
| DOI | 10.1016/j.phytol.2022.02.015 |
| 通讯作者 | Wang, Wen-Qiong(wenqiong1019@simm.ac.cn) ; Xuan, Li-Jiang(ljxuan@simm.ac.cn) |
| 英文摘要 | Phytochemical investigation of the aerial part of Hypericum japonicum afforded two new xanthones (1-2), together with twelve known compounds (3-14). Their structures with absolute configurations were elucidated by analysis of MS NMR and their experimental and calculated electronic circular dichroism spectra. All of the isolated compounds were tested for their lipid-lowering activities. Compounds 10, 11, 13 exhibited potent lipid-lowering activities (with LDL-Uptake rates 3.02, 2.68 and 1.99, respectively, compared with vehicle control, which was designated as 1.00) and compounds 2-5 showed moderate activities (with LDL-Uptake rates 1.46, 1.41, 1.31 and 1.51, respectively). |
| WOS关键词 | CONSTITUENTS |
| 资助项目 | State Key Laboratory of Drug Research (P.R. China)[SIMM 1601ZZ03] ; Youth Innovation Promotion Association (P.R. China)[2019284] ; Shanghai Municipal Science and Technology Major Project (P.R. China) |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | ELSEVIER |
| WOS记录号 | WOS:000884205100007 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/302921]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Wang, Wen-Qiong; Xuan, Li-Jiang |
| 作者单位 | 1.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210029, Jiangsu, Peoples R China 2.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 501 Haike Rd, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Guo, Peng-Ju,Chen, Tong,Zheng, Liu,et al. Two new xanthones from Hypericum japonicum and their lipid-lowering activities[J]. PHYTOCHEMISTRY LETTERS,2022,49:40-44. |
| APA | Guo, Peng-Ju.,Chen, Tong.,Zheng, Liu.,Peng, Shou.,Lv, Kai-Qing.,...&Xuan, Li-Jiang.(2022).Two new xanthones from Hypericum japonicum and their lipid-lowering activities.PHYTOCHEMISTRY LETTERS,49,40-44. |
| MLA | Guo, Peng-Ju,et al."Two new xanthones from Hypericum japonicum and their lipid-lowering activities".PHYTOCHEMISTRY LETTERS 49(2022):40-44. |
入库方式： OAI收割
来源：上海药物研究所
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