Phonerilins A-K, cytotoxic ingenane and ingol diterpenoids from Euphorbia neriifolia
文献类型：期刊论文
| 作者 | Gao, Yuan3,4; Zhou, Jun-Su4; Liu, Hong-Chun4 ; Zhang, Yan4; Yin, Wei-Hang2,4; Liu, Qun-Fang4; Wang, Guan-Wu1,3; Zhao, Jin-Xin4; Yue, Jian-Min2,4
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| 刊名 | TETRAHEDRON
 |
| 出版日期 | 2022-09-24 |
| 卷号 | 123页码:9 |
| ISSN号 | 0040-4020 |
| 关键词 | Euphorbia neriifolia Diterpenoid Ingenane Ingol Phonerilins A-K Cytotoxicity |
| DOI | 10.1016/j.tet.2022.132955 |
| 通讯作者 | Wang, Guan-Wu(gwang@ustc.edu.cn) ; Zhao, Jin-Xin(jxzhao@simm.ac.cn) ; Yue, Jian-Min(jmyue@simm.ac.cn) |
| 英文摘要 | A phytochemical study of the aerial parts of Euphorbia neriifolia led to the isolation of six new ingenane-type diterpenoids, phonerilins A-F (1-6), five new ingol-type diterpenoids, phonerilins G-K (7-11), and five known analogues (12-16). Their structures with absolute configurations were elucidated by a combined method. Phonerilin A (1) is the second rearranged ingenane diterpenoid with a unique 6/6/7/ 3-fused ring system. Based on single-crystal X-ray diffraction and NOESY data, the structure of 20-deoxy-16-hydroxyingenol was revised as 20-deoxy-17-hydroxyingenol (12) that is likely the biogenetic pre-cursor of 1. Biological evaluation revealed some isolates exhibited cytotoxic effects against two human tumor cell lines, A549 and HL-60.(c) 2022 Elsevier Ltd. All rights reserved. |
| WOS关键词 | ESTERS ; LATEX |
| 资助项目 | National NaturalScience Foundation[81872758] ; CAMS Innovation Fund for Medical Sciences[2019-I2M-5-080] ; Biological Resources Program of Chinese Academy of Sciences[KFJ-BRP-008-001] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| WOS记录号 | WOS:000876573000010 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/302987]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Wang, Guan-Wu; Zhao, Jin-Xin; Yue, Jian-Min |
| 作者单位 | 1.Univ Sci & Technol China, Dept Chem, Hefei 230026, Anhui, Peoples R China 2.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 3.Univ Sci & Technol China, Nano Sci & Technol Inst, Suzhou 215123, Jiangsu, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gao, Yuan,Zhou, Jun-Su,Liu, Hong-Chun,et al. Phonerilins A-K, cytotoxic ingenane and ingol diterpenoids from Euphorbia neriifolia[J]. TETRAHEDRON,2022,123:9. |
| APA | Gao, Yuan.,Zhou, Jun-Su.,Liu, Hong-Chun.,Zhang, Yan.,Yin, Wei-Hang.,...&Yue, Jian-Min.(2022).Phonerilins A-K, cytotoxic ingenane and ingol diterpenoids from Euphorbia neriifolia.TETRAHEDRON,123,9. |
| MLA | Gao, Yuan,et al."Phonerilins A-K, cytotoxic ingenane and ingol diterpenoids from Euphorbia neriifolia".TETRAHEDRON 123(2022):9. |
入库方式： OAI收割
来源：上海药物研究所
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