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Blocking Cholesterol Metabolism with Tumor-Penetrable Nanovesicles to Improve Photodynamic Cancer Immunotherapy

文献类型：期刊论文

作者Liu, Xiaochen2,3,4,5; Zhao, Zitong4,5; Sun, Xiangshi4,5; Wang, Jue4,5; Yi, Wenzhe4,5; Wang, Dangge3,4,5; Li, Yaping1,2,4,5
刊名SMALL METHODS
出版日期2022-10-28
页码14
ISSN号2366-9608
关键词cholesterol metabolism immunogenic cell death nanovesicles photodynamic immunotherapy tumor penetration
DOI10.1002/smtd.202200898
通讯作者Wang, Dangge(dgwang@simm.ac.cn) ; Li, Yaping(ypli@simm.ac.cn)
英文摘要Photodynamic therapy (PDT)-mediated cancer immunotherapy is attenuated due to the dysfunction of T cells in immunosuppressive tumor microenvironment (TME). Cholesterol metabolism plays a vital role in T cell signaling and effector. While the metabolic fitness of tumor infiltrating CD8(+) T cells is impaired by nutrition restriction in TME and accumulated metabolites by tumor cells. Here a matrix metalloproteinase-2-sensitive tumor-penetrable nanovesicle is designed to regulate cholesterol metabolism pathway for enhancing photodynamic cancer immunotherapy. The nanovesicles accumulate in tumor and release internalizing RGD to promote deep penetration. Released avasimibe from the nanovesicles simultaneously blocks cholesterol metabolism in CD8(+) T and tumor cells, thus reinvigorating the functions of T cells and suppressing the migration of tumor cells. Immune responses induced by PDT-triggered immunogenic cell death are further improved with cholesterol metabolism blockage. Compared with PDT alone, the designed nanovesicles display enhanced tumor growth inhibition in B16-F10 mouse tumor model. The approach provides an alternative strategy to improve photodynamic cancer immunotherapy by cholesterol metabolism intervention.
WOS关键词LIPID-METABOLISM ; ESTERIFICATION ; AVASIMIBE
资助项目National Natural Science Foundation of China[32170935] ; National Natural Science Foundation of China[81903548] ; National Natural Science Foundation of China[31930066] ; Youth Innovation Promotion Association of CAS[2019283] ; Shandong Provincial Natural Science Foundation[ZR2019ZD25]
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science
语种英语
出版者WILEY-V C H VERLAG GMBH
WOS记录号WOS:000875464500001
源URL[http://119.78.100.183/handle/2S10ELR8/302990]  
专题新药研究国家重点实验室
通讯作者Wang, Dangge; Li, Yaping
作者单位1.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264000, Shandong, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Yantai Inst Mat Med, Yantai Key Lab Nanomed & Adv Preparat, Yantai 264000, Shandong, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China
5.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Liu, Xiaochen,Zhao, Zitong,Sun, Xiangshi,et al. Blocking Cholesterol Metabolism with Tumor-Penetrable Nanovesicles to Improve Photodynamic Cancer Immunotherapy[J]. SMALL METHODS,2022:14.
APA Liu, Xiaochen.,Zhao, Zitong.,Sun, Xiangshi.,Wang, Jue.,Yi, Wenzhe.,...&Li, Yaping.(2022).Blocking Cholesterol Metabolism with Tumor-Penetrable Nanovesicles to Improve Photodynamic Cancer Immunotherapy.SMALL METHODS,14.
MLA Liu, Xiaochen,et al."Blocking Cholesterol Metabolism with Tumor-Penetrable Nanovesicles to Improve Photodynamic Cancer Immunotherapy".SMALL METHODS (2022):14.

入库方式： OAI收割

来源：上海药物研究所

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