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Surface Modifiers on Composite Particles for Direct Compaction

文献类型：期刊论文

作者Chen, Fu-Cai4; Liu, Wen-Jun3; Zhu, Wei-Feng4; Yang, Ling-Yu3; Zhang, Ji-Wen2,4; Feng, Yi1,4; Ming, Liang-Shan4; Li, Zhe4
刊名PHARMACEUTICS
出版日期2022-10-01
卷号14期号:10页码:41
关键词direct compaction particle structure surface modifier co-processing
DOI10.3390/pharmaceutics14102217
通讯作者Ming, Liang-Shan(mingls@jxutcm.edu.cn) ; Li, Zhe(20191004@jxutcm.edu.cn)
英文摘要Direct compaction (DC) is considered to be the most effective method of tablet production. However, only a small number of the active pharmaceutical ingredients (APIs) can be successfully manufactured into tablets using DC since most APIs lack adequate functional properties to meet DC requirements. The use of suitable modifiers and appropriate co-processing technologies can provide a promising approach for the preparation of composite particles with high functional properties. The purpose of this review is to provide an overview and classification of different modifiers and their multiple combinations that may improve API tableting properties or prepare composite excipients with appropriate co-processed technology, as well as discuss the corresponding modification mechanism. Moreover, it provides solutions for selecting appropriate modifiers and co-processing technologies to prepare composite particles with improved properties.
WOS关键词ACTIVE PHARMACEUTICAL INGREDIENT ; CRYSTALLO-CO-AGGLOMERATION ; IMPROVING FLOW PROPERTIES ; MICROCRYSTALLINE CELLULOSE ; DIRECT COMPRESSION ; HYDROXYPROPYL METHYLCELLULOSE ; DISSOLUTION RATE ; FUNCTIONAL-PROPERTIES ; ENHANCED DISSOLUTION ; COHESIVE POWDER
资助项目National Natural Science Foundation of China[82003953] ; National Natural Science Foundation of China[82204630] ; 2020-2022 Young Talents Support Project of Chinese Society of Chinese Medicine[2020-QNRC2-07] ; Natural Science Foundation of Jiangxi Province[20202BAB216039] ; Doctoral Research start-up Fund Project of Jiangxi University of Chinese Medicine[2021BSZR015] ; Jiangxi University of Chinese Medicine Science and Technology Innovation Team Development Program[CXTD22004] ; 2020 Innovation Leading Talents Short-term Program[5002/1262000107] ; 2020 Innovation Leading Talents Short-term Program[5002/1262000102] ; 2020 Innovation Leading Talents Short-term Program[jxsq2019102077]
WOS研究方向Pharmacology & Pharmacy
语种英语
出版者MDPI
WOS记录号WOS:000875971600001
源URL[http://119.78.100.183/handle/2S10ELR8/302999]  
专题中国科学院上海药物研究所
通讯作者Ming, Liang-Shan; Li, Zhe
作者单位1.Shanghai Univ Tradit Chinese Med, Engn Res Ctr Modern Preparat Technol TCM, Minist Educ, Shanghai 201203, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
3.Jiangzhong Pharmaceut Co Ltd, Nanchang 330049, Jiangxi, Peoples R China
4.Jiangxi Univ Chinese Med, Minist Educ, Key Lab Preparat Modern TCM, Nanchang 330004, Jiangxi, Peoples R China
推荐引用方式
GB/T 7714		 Chen, Fu-Cai,Liu, Wen-Jun,Zhu, Wei-Feng,et al. Surface Modifiers on Composite Particles for Direct Compaction[J]. PHARMACEUTICS,2022,14(10):41.
APA Chen, Fu-Cai.,Liu, Wen-Jun.,Zhu, Wei-Feng.,Yang, Ling-Yu.,Zhang, Ji-Wen.,...&Li, Zhe.(2022).Surface Modifiers on Composite Particles for Direct Compaction.PHARMACEUTICS,14(10),41.
MLA Chen, Fu-Cai,et al."Surface Modifiers on Composite Particles for Direct Compaction".PHARMACEUTICS 14.10(2022):41.

入库方式： OAI收割

来源：上海药物研究所

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