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A homogalacturonan from Lonicera japonica Thunb. disrupts angiogenesis via epidermal growth factor receptor and Delta-like 4 associated signaling

文献类型：期刊论文

作者Liao, Wenfeng3,4; Hu, Xiaodong3,4; Du, Zhenyun3,4; Wang, Peipei2,4; Ding, Kan1,3,4
刊名GLYCOCONJUGATE JOURNAL
出版日期2022-10-28
页码11
关键词Homogalacturonan Angiogenesis Lonicera japonica EGFR/Raf/MEK/ERK signaling cascade Dll4/Notch1 signaling
ISSN号0282-0080
DOI10.1007/s10719-022-10088-2
通讯作者Wang, Peipei(ppwang@shou.edu.cn) ; Ding, Kan(dingkan@simm.ac.cn)
英文摘要A homogeneous polysaccharide named as LJW2F2 was extracted and purified from the flowers of Lonicera japonica Thunb. Structural characteristic indicated that LJW2F2 was a homogalacturonan composed of alpha-1,4-D-galacturonic acid with a molecular weight of 7.2 kDa. Previous investigation suggested that homogalacturonan might impede angiogenesis, however the mechanism is still vague. Here we reported that LJW2F2 significantly disrupted capillary-like tube formation of human microvascular endothelia cells (HMEC-1) on matrigel as well as the cells migration. Mechanism study revealed that LJW2F2 might inactivate phosphorylation of epidermal growth factor receptor (EGFR), subsequently suppress Raf, mitogen-activated protein kinase (MEK) and extracellular-related kinase (ERK) phosphorylation. Moreover, LJW2F2 markedly decreased the expression of Notch1 and Delta-like ligand 4 (Dll4). Therefore, our results suggested that LJW2F2 might be a potential angiogenesis inhibitor via disturbing multiple signaling pathways.
WOS关键词IMMUNOMODULATORY ACTIVITY ; STRUCTURAL ELUCIDATION ; INHIBITS ANGIOGENESIS ; BIOLOGICAL-ACTIVITIES ; POLYSACCHARIDE ; FLOWERS ; EGFR ; FUCOIDAN ; PECTIN ; AGGREGATION
资助项目National Key R&D Program of China[2019YFC1711000] ; Shanghai Municipal Science and Technology Major Project ; National Natural Science Foundation of China[31870801]
WOS研究方向Biochemistry & Molecular Biology
语种英语
WOS记录号WOS:000875518700001
出版者SPRINGER
源URL[http://119.78.100.183/handle/2S10ELR8/303005]  
专题新药研究国家重点实验室
通讯作者Wang, Peipei; Ding, Kan
作者单位1.Hinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, SSIP Healthcare & Med Demonstrat Zone, Zhongshan 528400, Peoples R China
2.Shanghai Ocean Univ, Coll Food Sci & Technol, Shanghai 201306, Peoples R China
3.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Glycochem & Glycobiol Lab,CAS Key Lab Receptor Re, 555 Chong Zhi Rd, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Liao, Wenfeng,Hu, Xiaodong,Du, Zhenyun,et al. A homogalacturonan from Lonicera japonica Thunb. disrupts angiogenesis via epidermal growth factor receptor and Delta-like 4 associated signaling[J]. GLYCOCONJUGATE JOURNAL,2022:11.
APA Liao, Wenfeng,Hu, Xiaodong,Du, Zhenyun,Wang, Peipei,&Ding, Kan.(2022).A homogalacturonan from Lonicera japonica Thunb. disrupts angiogenesis via epidermal growth factor receptor and Delta-like 4 associated signaling.GLYCOCONJUGATE JOURNAL,11.
MLA Liao, Wenfeng,et al."A homogalacturonan from Lonicera japonica Thunb. disrupts angiogenesis via epidermal growth factor receptor and Delta-like 4 associated signaling".GLYCOCONJUGATE JOURNAL (2022):11.

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来源：上海药物研究所

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