中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 上海药物研究所
  3. 中国科学院上海药物研究所
  4. 新药研究国家重点实验室
Microvesicle-inspired oxygen-delivering nanosystem potentiates radiotherapy-mediated modulation of tumor stroma and antitumor immunity

文献类型：期刊论文

作者Gong, Xiang4,5; Li, Jie4,5; Xu, Xiaoxuan4,5; Wu, Yao2,3,4,5; Lei, Ying1; Liu, Huanzhen1; Qian, Xindi4,5; Li, Yaping4,5; Zhang, Zhiwen2,3,4,5
刊名BIOMATERIALS
出版日期2022-11-01
卷号290页码:19
关键词Microvesicle Tumor hypoxia Tumor stroma Radiotherapy Anti-tumor immune response
ISSN号0142-9612
DOI10.1016/j.biomaterials.2022.121855
通讯作者Zhang, Zhiwen(zhangzhiwen@fudan.edu.cn)
英文摘要The efficacy of radiotherapy is greatly challenged by intense hypoxia, intricate stroma and suppressive immune microenvironments in tumors. Herein, we rationally designed a microvesicle-inspired oxygen-delivering poly -fluorocarbon nanosystem loading DiIC18(5) and halofuginone (M-FDH) with prominent capacity of improving tumor oxygenation and intratumor distribution, synergizing radiation to disrupt tumor stroma and boost anti-tumor immunity for combinational cancer therapy. M-FDH produced a 10.98-fold enhancement of tumor oxygenation and caused efficient production of reactive oxygen species (ROS) upon radiation. M-FDH + X ray treatment resulted in notable DNA damages, over 90% elimination of cancer-associated fibroblasts (CAFs) and major components of extracellular matrix, significant enhancement of tumoricidal CD3+CD8+ T cells, and pro-found elimination of suppressive immune cells in 4T1 tumors. The therapeutic benefits of M-FDH + X ray on suppressing tumor growth were confirmed in two murine tumor models. Therefore, this study provides an encouraging microvesicle-inspired strategy to target cancer cells and CAFs in tumors and synergize radiotherapy for effective cancer treatment.
WOS关键词CELL ; FIBROBLASTS ; MICROENVIRONMENT ; HYPOXIA
资助项目National Natural Science Foundation of China ; Shandong Province Natural Science Foundation ; [32071385] ; [31930066] ; [ZR2019ZD25]
WOS研究方向Engineering ; Materials Science
语种英语
WOS记录号WOS:000876699700001
出版者ELSEVIER SCI LTD
源URL[http://119.78.100.183/handle/2S10ELR8/303017]  
专题新药研究国家重点实验室
通讯作者Zhang, Zhiwen
作者单位1.ShanghaiTech Univ, Shanghai Inst Adv Immunochem Studies SIAIS, Shanghai, Peoples R China
2.Fudan Univ, Key Lab Smart Drug Delivery, Minist Educ, Shanghai 201203, Peoples R China
3.Fudan Univ, Sch Pharm, Shanghai 201203, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China
5.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Gong, Xiang,Li, Jie,Xu, Xiaoxuan,et al. Microvesicle-inspired oxygen-delivering nanosystem potentiates radiotherapy-mediated modulation of tumor stroma and antitumor immunity[J]. BIOMATERIALS,2022,290:19.
APA Gong, Xiang.,Li, Jie.,Xu, Xiaoxuan.,Wu, Yao.,Lei, Ying.,...&Zhang, Zhiwen.(2022).Microvesicle-inspired oxygen-delivering nanosystem potentiates radiotherapy-mediated modulation of tumor stroma and antitumor immunity.BIOMATERIALS,290,19.
MLA Gong, Xiang,et al."Microvesicle-inspired oxygen-delivering nanosystem potentiates radiotherapy-mediated modulation of tumor stroma and antitumor immunity".BIOMATERIALS 290(2022):19.

入库方式： OAI收割

来源：上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。