Whole-transcriptome sequencing data reveals a disparate cognitive and immune signature in COVID-19 patients with and without dementia
文献类型:期刊论文
作者 | Yang, Jue1,2,3,4,5,6; Song, Hui2,3; Hao, Xiaojiang4,5,6 |
刊名 | JOURNAL OF MEDICAL VIROLOGY |
出版日期 | 2022-10-26 |
页码 | 10 |
ISSN号 | 0146-6615 |
关键词 | Alzheimer's disease COVID-19 dementia immune response SARS-CoV-2 |
DOI | 10.1002/jmv.28177 |
通讯作者 | Song, Hui(songhui620@126.com) ; Hao, Xiaojiang(haoxj2013@126.com) |
英文摘要 | The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused more than 6.3 million deaths worldwide. Recent evidence has indicated that elderly people with dementia are particularly vulnerable to COVID-19 and severe disease outcomes. However, its molecular mechanism remains largely unknown. Here, we retrieved frontal cortex samples of COVID-19 patients from the Gene Expression Omnibus database and performed a systematic transcriptomic analysis to compare COVID-19 patients and controls with or without dementia. In nondemented patients, SARS-CoV-2 infection obviously activated T helper type 2 (Th2) cell-mediated humoral immunity and reduced the pathogenesis of dementia-related Alzheimer's disease and Parkinson's disease. In demented patients, conversely, SARS-CoV-2 infection significantly increased T helper type 1 (Th1) cell-mediated cellular immunity and exacerbated the progression of dementia-related diseases. We further analyzed the molecular characteristics of COVID-19 patients with and without dementia. Compared with nondemented COVID-19 patients, demented COVID-19 patients showed decreased enrichment scores of Calcium signaling pathway, Neuroactive ligand-receptor interaction, ABC transporters, and Peroxisome, and increased enrichment scores of Olfactory transduction and Regulation of autophagy. The ratio of Th1/Th2 cells was significantly increased from 1.17 in nondemented COVID-19 patients to 33.32 in demented COVID-19 patients. Taken together, our findings provide transcriptomic evidence that COVID-19 has distinct influences on cognitive function and immune response in patients with and without dementia. |
WOS关键词 | PROTEIN ; GENOME ; IMPACT |
资助项目 | Guizhou Provincial Natural Science and Technology Projects[QKHZK[2021]526] ; Guizhou Provincial Natural Science and Technology Projects[QKHZK[2021]448] ; State Key Laboratory of Drug Research[SIMM2105KF-15] ; National Natural Science Foundation of China[82160813] ; National Natural Science Foundation of China[32060210] |
WOS研究方向 | Virology |
语种 | 英语 |
出版者 | WILEY |
WOS记录号 | WOS:000872085900001 |
源URL | [http://119.78.100.183/handle/2S10ELR8/303097] |
专题 | 新药研究国家重点实验室 |
通讯作者 | Song, Hui; Hao, Xiaojiang |
作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai, Peoples R China 2.Guizhou Med Univ, Key Lab Med Mol Biol Guizhou Prov, Guiyang, Peoples R China 3.Guizhou Med Univ, Key Lab Endem & Ethn Dis, Minist Educ, Guiyang, Peoples R China 4.Chinese Acad Sci, Guiyang, Peoples R China 5.Key Lab Chem Nat Prod Guizhou Prov, Guiyang, Peoples R China 6.Guizhou Med Univ, State Key Lab Funct & Applicat Med Plants, Guiyang, Peoples R China |
推荐引用方式 GB/T 7714 | Yang, Jue,Song, Hui,Hao, Xiaojiang. Whole-transcriptome sequencing data reveals a disparate cognitive and immune signature in COVID-19 patients with and without dementia[J]. JOURNAL OF MEDICAL VIROLOGY,2022:10. |
APA | Yang, Jue,Song, Hui,&Hao, Xiaojiang.(2022).Whole-transcriptome sequencing data reveals a disparate cognitive and immune signature in COVID-19 patients with and without dementia.JOURNAL OF MEDICAL VIROLOGY,10. |
MLA | Yang, Jue,et al."Whole-transcriptome sequencing data reveals a disparate cognitive and immune signature in COVID-19 patients with and without dementia".JOURNAL OF MEDICAL VIROLOGY (2022):10. |
入库方式: OAI收割
来源:上海药物研究所
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