Shape-directed drug release and transport of erythrocyte-like nanodisks augment chemotherapy
文献类型：期刊论文
| 作者 | Wang, Ning2,3; Li, Jingyi1,3; Wang, Jie1,3; Nie, Di2,3; Jiang, Xiaohe2,3; Zhuo, Yan3; Yu, Miaorong2,3 |
| 刊名 | JOURNAL OF CONTROLLED RELEASE
 |
| 出版日期 | 2022-10-01 |
| 卷号 | 350页码:886-897 |
| 关键词 | Erythrocyte -like nanoparticles Shape effect Drug release Tumor penetration Biological barriers |
| ISSN号 | 0168-3659 |
| DOI | 10.1016/j.jconrel.2022.09.005 |
| 通讯作者 | Yu, Miaorong(mryu@simm.ac.cn) |
| 英文摘要 | Nanoparticle shape has been recognized as a crucial parameter to affect the transport across various biological barriers, but its impact on drug release and the resulting therapeutic efficacy is less understood. Inspired by erythrocytes with shape-facilitated oxygen-carrying and penetrating abilities, we constructed artificial erythrocyte-like nanoparticles (RNDs) by wrapping discoidal mesoporous silica nanoparticles with red blood cell membrane. We observed that, compared with their spherical and rod-shaped counterparts with monotonic drug release profiles, RNDs displayed an on-demand drug release pattern mimicking natural erythrocytes, that is, they could rapidly release loaded oxygen and doxorubicin (DOX) in hypoxic condition but were relatively stable in high oxygen areas. Besides, the discoidal shape also endowed RNDs with facilitated transport capability in tumor extracellular matrix, contributing to increased tumor permeability. In tumor models, systemically administrated RNDs efficiently infiltrate throughout tumor tissue, successfully relieve tumor hypoxia, and further altered the cancer cell cycle status from G1 to G2 phase, enhancing cancer cell sensitivity to DOX correlated with improved chemotherapy efficacy. In contrast, nanospheres show hampered permeability, and nanorods suffer from insufficient intratumoral drug accumulation. These findings can offer guidelines for the use of particle shape as a design criterion to control drug release, transportation, and therapeutics delivery. |
| WOS关键词 | TUMOR PENETRATION ; NANOPARTICLES ; NANORODS ; DELIVERY ; BIODISTRIBUTION |
| 资助项目 | National Natural Science Foundation of China[82073773] ; Shanghai Institute of Materia Medica, CAS |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000874900400003 |
| 出版者 | ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/303121]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Yu, Miaorong |
| 作者单位 | 1.Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai 201203, Peoples R China 2.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Ning,Li, Jingyi,Wang, Jie,et al. Shape-directed drug release and transport of erythrocyte-like nanodisks augment chemotherapy[J]. JOURNAL OF CONTROLLED RELEASE,2022,350:886-897. |
| APA | Wang, Ning.,Li, Jingyi.,Wang, Jie.,Nie, Di.,Jiang, Xiaohe.,...&Yu, Miaorong.(2022).Shape-directed drug release and transport of erythrocyte-like nanodisks augment chemotherapy.JOURNAL OF CONTROLLED RELEASE,350,886-897. |
| MLA | Wang, Ning,et al."Shape-directed drug release and transport of erythrocyte-like nanodisks augment chemotherapy".JOURNAL OF CONTROLLED RELEASE 350(2022):886-897. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。