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Ocellatuperoxides A-F, Uncommon Anti-Tumoral gamma-Pyrone Peroxides from a Photosynthetic Mollusk Placobranchus ocellatus

文献类型：期刊论文

作者Li, Song-Wei3,4; Wu, Qihao4; Xu, Heng4; Yao, Li-Gong1,2,4; Luo, Cheng1,4; Wang, Hong3; Zhang, Hao4; Li, Xu-Wen1,2,4; Guo, Yue-Wei1,2,3,4
刊名MARINE DRUGS
出版日期2022-10-01
卷号20期号:10页码:14
关键词photosynthetic mollusk Placobranchus ocellatus gamma-pyrone polypropionate ocellatuperoxides anti-tumoral activity
DOI10.3390/md20100590
通讯作者Zhang, Hao(hao_cadd@simm.ac.cn) ; Li, Xu-Wen(xwli@simm.ac.cn) ; Guo, Yue-Wei(ywguo@simm.ac.cn)
英文摘要Six new pairs of gamma-pyrone polypropionate enantiomers with an unusual peroxyl bridge at the side chain, namely (+/-)-ocellatuperoxides A-F (1-6), were isolated and characterized from the South China Sea photosynthetic mollusk Placobranchus ocellatus. Extensive spectroscopic analysis, single crystal X-ray diffraction analysis, ECD- (electronic circular dichroism) comparison, and TDDFT (time-dependent density functional theory) ECD computation were used to determine the structures and absolute configurations of new compounds. In a cell viability assay, several compounds showed considerable anti-tumoral effects on human non-small cell lung cancer cells A549 with Gefitinib (7.4 mu M) and Erlotinib (2.1 mu M) as positive controls. Further RNA-sequencing analysis and gene expression evaluation indicated that the anti-tumoral activity of the most effective compound 3 was associated with the regulation of several important genes, such as FGFR1 and HDAC5.
WOS关键词MARINE ; METABOLITES
资助项目National Key Research and Development Program of China[2021YFF0502400] ; National Natural Science Foundation of China[81991521] ; National Natural Science Foundation of China[82022069] ; National Natural Science Foundation of China[42076099] ; Shanghai Rising-Star Program[20QA1411100] ; Youth Innovation Promotion Association of Chinese Academy of Sciences[Y202065] ; SKLDR/SIMM Project[SIMM2103ZZ-06]
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000873263500001
出版者MDPI
源URL[http://119.78.100.183/handle/2S10ELR8/303127]  
专题新药研究国家重点实验室
通讯作者Zhang, Hao; Li, Xu-Wen; Guo, Yue-Wei
作者单位1.Qingdao Natl Lab Marine Sci & Technol, Open Studio Druggabil Res Marine Nat Prod, 1 Wenhai Rd, Qingdao 266237, Peoples R China
2.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Peoples R China
3.Zhejiang Univ Technol, Coll Pharmaceut Sci, Collaborat Innovat Ctr Yangtze River Delta Reg Gr, Hangzhou 310014, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Li, Song-Wei,Wu, Qihao,Xu, Heng,et al. Ocellatuperoxides A-F, Uncommon Anti-Tumoral gamma-Pyrone Peroxides from a Photosynthetic Mollusk Placobranchus ocellatus[J]. MARINE DRUGS,2022,20(10):14.
APA Li, Song-Wei.,Wu, Qihao.,Xu, Heng.,Yao, Li-Gong.,Luo, Cheng.,...&Guo, Yue-Wei.(2022).Ocellatuperoxides A-F, Uncommon Anti-Tumoral gamma-Pyrone Peroxides from a Photosynthetic Mollusk Placobranchus ocellatus.MARINE DRUGS,20(10),14.
MLA Li, Song-Wei,et al."Ocellatuperoxides A-F, Uncommon Anti-Tumoral gamma-Pyrone Peroxides from a Photosynthetic Mollusk Placobranchus ocellatus".MARINE DRUGS 20.10(2022):14.

入库方式： OAI收割

来源：上海药物研究所

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