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Ethyl Acetate Extract of Dracocephalum heterophyllum Benth Ameliorates Nonalcoholic Steatohepatitis and Fibrosis via Regulating Bile Acid Metabolism, Oxidative Stress and Inhibiting Inflammation

文献类型：期刊论文

作者Fang, Yan3,4; Sun, Dandan1,2; Li, Gang3; Lv, Yue3; Li, Jia2; Wang, Qilan4; Dang, Jun4
刊名SEPARATIONS
出版日期2022-10-01
卷号9期号:10页码:24
关键词Dracocephalum heterophyllum benth preparative separation nonalcoholic steatohepatitis liver fibrosis molecular docking
DOI10.3390/separations9100273
通讯作者Wang, Qilan(wql@nwipb.cas.cn) ; Dang, Jun(dangjun@nwipb.cas.cn)
英文摘要Dracocephalum heterophyllum Benth is well-known for its ability to alleviate liver heat. In this study, Dracocephalum heterophyllum Benth ethyl acetate extracts were evaluated on mouse models of nonalcoholic steatohepatitis and liver fibrosis. After 6 and 8 weeks of treatment, serum parameters and gene expressions in tissue samples, as well as stained tissue sections, demonstrated that the ethyl acetate extracts were effective in treating these liver diseases. The principal bioactive constituent (rosmarinic acid) was identified and screened by high pressure liquid chromatography-1,1-diphenyl-2-picrylhydrazyl and affinity ultrafiltration-HPLC. The rosmarinic acid was separated from extracts with high purity by medium- and high-pressure liquid chromatography. Finally, the interactions between rosmarinic acid and the key targets of lipid metabolism, oxidative stress and inflammation were verified by molecular docking. Thereby, an indirect regulation of lipid and cholesterol metabolism and inhibition of liver inflammation and liver fibrosis by the studied extract has been observed. This study demonstrated that Dracocephalum heterophyllum Benth ethyl acetate extracts have the potential to treat nonalcoholic steatohepatitis and liver fibrosis, revealing their multi-target and multi-pathway therapeutic characteristics.
WOS关键词NATURAL-PRODUCTS ; DISCOVERY ; TARGET
资助项目International Cooperation Project of Qinghai Province[2020-HZ-804]
WOS研究方向Chemistry
语种英语
出版者MDPI
WOS记录号WOS:000875390300001
源URL[http://119.78.100.183/handle/2S10ELR8/303133]  
专题新药研究国家重点实验室
通讯作者Wang, Qilan; Dang, Jun
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
2.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China
3.Yantai Univ, Coll Life Sci, Ctr Mitochondria & Hlth Aging, Yantai 264005, Peoples R China
4.Chinese Acad Sci, Northwest Inst Plateau Biol, Qinghai Prov Key Lab Tibetan Med Res, Key Lab Tibetan Med Res, Xining 810001, Peoples R China
推荐引用方式
GB/T 7714		 Fang, Yan,Sun, Dandan,Li, Gang,et al. Ethyl Acetate Extract of Dracocephalum heterophyllum Benth Ameliorates Nonalcoholic Steatohepatitis and Fibrosis via Regulating Bile Acid Metabolism, Oxidative Stress and Inhibiting Inflammation[J]. SEPARATIONS,2022,9(10):24.
APA Fang, Yan.,Sun, Dandan.,Li, Gang.,Lv, Yue.,Li, Jia.,...&Dang, Jun.(2022).Ethyl Acetate Extract of Dracocephalum heterophyllum Benth Ameliorates Nonalcoholic Steatohepatitis and Fibrosis via Regulating Bile Acid Metabolism, Oxidative Stress and Inhibiting Inflammation.SEPARATIONS,9(10),24.
MLA Fang, Yan,et al."Ethyl Acetate Extract of Dracocephalum heterophyllum Benth Ameliorates Nonalcoholic Steatohepatitis and Fibrosis via Regulating Bile Acid Metabolism, Oxidative Stress and Inhibiting Inflammation".SEPARATIONS 9.10(2022):24.

入库方式： OAI收割

来源：上海药物研究所

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