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Uncommon Capnosane Diterpenes with Neuroprotective Potential from South China Sea Soft Coral Sarcophyton boettgeri

文献类型：期刊论文

作者Du, Ye-Qing6,7; Chen, Jing6,7; Wu, Meng-Jun1,2,6; Zhang, Hai-Yan6,7; Liang, Lin-Fu5; Guo, Yue-Wei1,2,3,4,6,7
刊名MARINE DRUGS
出版日期2022-10-01
卷号20期号:10页码:14
关键词soft coral Sarcophyton boettgeri capnosane absolute configuration neuroprotective effect
DOI10.3390/md20100602
通讯作者Zhang, Hai-Yan(hzhang@simm.ac.cn) ; Liang, Lin-Fu(lianglinfu@csuft.edu.cn) ; Guo, Yue-Wei(ywguo@simm.ac.cn)
英文摘要The first investigation of the South China Sea soft coral Sarcophyton boettgeri afforded five new capnosane diterpenes, sarboettgerins A-E (1-5), together with one known related compound, pavidolide D (6). Their structures, including absolute configurations, were elucidated by the extensive spectroscopic analysis, C-13 NMR calculations, and X-ray diffraction. Among them, new compounds 1-5 were featured by the rarely encountered Z-geometry double bond Delta(1) within the 5/11-fused bicyclic capnosane carbon framework. Plausible biogenetic relationships of all isolates were proposed, and they might give an insight into future biomimetic synthesis of these novel compounds. In an in vitro bioassay, compound 5 displayed potent anti-neuroinflammatory activity against LPS-induced NO release in BV-2 microglial cells, which might be developed as a new type of potential neuroprotective agent in future.
WOS关键词A-C ; CEMBRANOIDS ; TROCHELIOPHORUM ; SARSOLENANE
资助项目National Natural Science Foundation of China (NSFC)[81991521] ; National Natural Science Foundation of China (NSFC)[41876194] ; SKLDR/SIMM Project[SIMM2103ZZ-06]
WOS研究方向Pharmacology & Pharmacy
语种英语
出版者MDPI
WOS记录号WOS:000873136400001
源URL[http://119.78.100.183/handle/2S10ELR8/303139]  
专题新药研究国家重点实验室
通讯作者Zhang, Hai-Yan; Liang, Lin-Fu; Guo, Yue-Wei
作者单位1.Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Peoples R China
2.Zhejiang Univ Technol, Collaborat Innovat Ctr Yangtze River Delta Reg Gr, Hangzhou 310014, Peoples R China
3.Pilot Natl Lab Marine Sci & Technol Qingdao, Open Studio Druggabil Res Marine Nat Prod, 1 Wenhai Rd, Qingdao 266237, Peoples R China
4.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Peoples R China
5.Cent South Univ Forestry & Technol, Coll Mat Sci & Engn, 498 South Shaoshan Rd, Changsha 410004, Peoples R China
6.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China
7.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China
推荐引用方式
GB/T 7714		 Du, Ye-Qing,Chen, Jing,Wu, Meng-Jun,et al. Uncommon Capnosane Diterpenes with Neuroprotective Potential from South China Sea Soft Coral Sarcophyton boettgeri[J]. MARINE DRUGS,2022,20(10):14.
APA Du, Ye-Qing,Chen, Jing,Wu, Meng-Jun,Zhang, Hai-Yan,Liang, Lin-Fu,&Guo, Yue-Wei.(2022).Uncommon Capnosane Diterpenes with Neuroprotective Potential from South China Sea Soft Coral Sarcophyton boettgeri.MARINE DRUGS,20(10),14.
MLA Du, Ye-Qing,et al."Uncommon Capnosane Diterpenes with Neuroprotective Potential from South China Sea Soft Coral Sarcophyton boettgeri".MARINE DRUGS 20.10(2022):14.

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来源：上海药物研究所

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