Therapeutic potential of traditional Chinese medicine for the treatment of NAFLD: A promising drug Potentilla discolor Bunge
文献类型：期刊论文
| 作者 | Ji, Longshan4; Li, Qian4; He, Yong3; Zhang, Xin4; Zhou, Zhenhua2; Gao, Yating4; Fang, Miao4; Yu, Zhuo2; Rodrigues, Robim M.1; Gao, Yueqiu4 |
| 刊名 | ACTA PHARMACEUTICA SINICA B
 |
| 出版日期 | 2022-09-01 |
| 卷号 | 12期号:9页码:3529-3547 |
| ISSN号 | 2211-3835 |
| 关键词 | Anti-inflammatory Lipid metabolism Insulin resistance Endoplasmic reticulum stress Intestinal microflora Nonalcoholic fatty liver disease (NAFLD) Traditional Chinese medicine Acupuncture Potentilla discolor Bunge (PDB) Natural active compounds Anti-oxidative |
| DOI | 10.1016/j.apsb.2022.05.001 |
| 通讯作者 | Rodrigues, Robim M.(robim.marcelino.rodrigues@vub.be) ; Gao, Yueqiu(gaoyueqiu@shutcm.edu.cn) ; Li, Man(liman121000@shutcm.edu.cn) |
| 英文摘要 | Nonalcoholic fatty liver disease (NAFLD) is characterized by excessive accumulation of he-patic lipids and metabolic stress-induced liver injury. There are currently no approved effective pharma-cological treatments for NAFLD. Traditional Chinese medicine (TCM) has been used for centuries to treat patients with chronic liver diseases without clear disease types and mechanisms. More recently, TCM has been shown to have unique advantages in the treatment of NAFLD. We performed a systematic review of the medical literature published over the last two decades and found that many TCM formulas have been reported to be beneficial for the treatment of metabolic dysfunctions, including Potentilla discolor Bunge (PDB). PDB has a variety of active compounds, including flavonoids, terpenoids, organic acids, steroids and tannins. Many compounds have been shown to exhibit a series of beneficial effects for the treatment of NAFLD, including anti-oxidative and anti-inflammatory functions, improvement of lipid metabolism and reversal of insulin resistance. In this review, we summarize potential therapeutic effects of TCM formulas for the treatment of NAFLD, focusing on the medicinal properties of natural active compounds from PDB and their underlying mechanisms. We point out that PDB can be classified as a novel candidate for the treatment and prevention of NAFLD. 2022 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| WOS关键词 | FATTY LIVER-DISEASE ; DIET-INDUCED OBESITY ; CHAIHU-SHUGAN-SAN ; HFD-INDUCED NAFLD ; NONALCOHOLIC STEATOHEPATITIS ; EXTRACELLULAR VESICLES ; OXIDATIVE STRESS ; OLEANOLIC ACID ; INTESTINAL MICROBIOTA ; INSULIN SENSITIVITY |
| 资助项目 | National Natural Science Foundation of China (China)[82074155] ; National Natural Science Foundation of China (China)[81874436] ; National Natural Science Foundation of China (China)[81973773] ; Shanghai Education Development Foundation ; Shanghai Municipal Education Commission (China)[18SG39] ; Program of Shanghai Academic/Technology Research Leader (China)[20XD1423500] ; Clinical Research Plan of SHDC (China)[SHDC2020CR3089B] ; Shanghai Key Clinical Specialty Construction Project (China)[shslczdzk01201] ; Shanghai Frontier Research Base of Disease and Syndrome Biology of inflammatory cancer transformation (China)[2021KJ03-12] ; Shanghai Sailing Program (China)[20YF1450200] ; Shanghai Collaborative Innovation Center of Industrial Transformation of Hospital TCM Preparation (China) |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | INST MATERIA MEDICA, CHINESE ACAD MEDICAL SCIENCES |
| WOS记录号 | WOS:000864826500007 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/303142]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Rodrigues, Robim M.; Gao, Yueqiu; Li, Man |
| 作者单位 | 1.Vrije Univ Brussel, Fac Med & Pharm, Dept Vitro Toxicol & Dermatocosmetol, B-1000 Brussels, Belgium 2.Shanghai Univ Tradit Chinese Med, Dept Hepatopathy, Shuguang Hosp, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 4.Shanghai Univ Tradit Chinese Med, Shuguang Hosp, Inst Clin Immunol, Lab Cellular Immun,Shanghai Key Lab Tradit Chinese, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ji, Longshan,Li, Qian,He, Yong,et al. Therapeutic potential of traditional Chinese medicine for the treatment of NAFLD: A promising drug Potentilla discolor Bunge[J]. ACTA PHARMACEUTICA SINICA B,2022,12(9):3529-3547. |
| APA | Ji, Longshan.,Li, Qian.,He, Yong.,Zhang, Xin.,Zhou, Zhenhua.,...&Li, Man.(2022).Therapeutic potential of traditional Chinese medicine for the treatment of NAFLD: A promising drug Potentilla discolor Bunge.ACTA PHARMACEUTICA SINICA B,12(9),3529-3547. |
| MLA | Ji, Longshan,et al."Therapeutic potential of traditional Chinese medicine for the treatment of NAFLD: A promising drug Potentilla discolor Bunge".ACTA PHARMACEUTICA SINICA B 12.9(2022):3529-3547. |
入库方式： OAI收割
来源：上海药物研究所
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